Thread by @DrSherani432

1) GEFS plus (Genetic Epilepsy with Febrile Seizures plus)
Mildest Benign Form: Normal EEG + IMAGING
1:Simple Febrile Seizures
2:Febrile Seizures Plus
Severe Form: Abnormal EEG + IMAGING
3:Dravet Syndrome
4:Doose Syndrome

2) GEFS plus is a genetic syndrome, Defect in 4 Genes, SCN1A, SCN1B, GABRG2, GABRD. Other seizures with FS Or FS-plus are Absence, atonic, myoclonic, and partial.
FS:
Typical convulsive seizures, 6month-6years, with fever 38c' or greater.

3) FS-plus:
Mild form of generalized epilepsy, different presentations.
1:Febrile Seizures continues past 6 years which is upper limit of FS, than decrease gradually.
2:Febrile Seizures and Afebrile seizures upto typical age for Febrile Seizures.(6 months to 6 years).

4) 3:Afebrile seizures continues after febrile seizures stops.

5) Doose Syndrome (MAE):
Have multiple types of Seizures like Febrile, Afebrile, Atonic(drop attack), Myoclonic. Disease start with febrile convulsions. EEG Generalized fast Spike-Waves at >3Hz.

6) Dravet Syndrome (SMEI) :
>70% patients have SCN1A mutations, 50% of cases have family history of Epilepsy or Febrile Seizures.

7) Partial Epilepsies:
Partial Epilepsies with preceeding febrile seizures are well recognized to be part of GEFS-plus Spectrum. SCN1A, SCN1B, GABRG2 mutations have been found.

8) Temporal Lobe epilepsy has been reported frequently. Hippocampal Sclerosis have been seen with preceeding FS or FS-plus. Frontal lobe has also been described.

#Neurology #neurologyresident #neurologist #MedTwitter #Exam #epilepsy #Genetics

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