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New @AIP_Publishing: Demonstration of why air shields alone and N95 masks with valves are not adequate protection
aip.scitation.org/journal/phf
N95 with valve
N95 without a valve
Surgical mask, good brand
Surgical mask, bad brand (they are not all =)
and corrected link to the paper for more info
aip.scitation.org/doi/10.1063/5.…
Good summary of this interesting study by @taraparkerpope nytimes.com/2020/09/01/wel…
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Eric Topol
@EricTopol
On the #SARSCoV2 immune response and vaccine I just did a podcast with Dennis Burton, a leading immunologist and vaccinologist and co-faculty @scrippsresearch. We covered so much a long🧵summary was needed
soundcloud.com/prescrippsions… 1/x
Optimism. "The pandemic is not going to be with us forever"
(This comes from a leader of the HIV vaccine program) 2/x Image
1st line of defense, interferons: will they likely be helpful given as an early intervention?
Yes, but we have to be very careful 3/x Image
Read 16 tweets
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Eric Topol
@EricTopol
Very good news on durable IgG antibodies to #SARSCoV2 from the Iceland experience
Just published @NEJM
nejm.org/doi/full/10.10… >4 months out
Iceland was one of the best performing countries vs #COVID19, starting PCR screening in January, before there was even a patient diagnosed. As a result, along with tracing/isolation, they have a seroprevalence of only 0.9% (US is now >14%, estimated) and IFR 0.3%.
The editorial is rich with context
nejm.org/doi/full/10.10…
1. "Unprecedented snapshot of seroconversion rates" with various antibody isotopes, different antigens
2. 56% cases confirmed by virus (PCR) testing so 44% infections would've been missed w/o antibody
3. 2 Waves graphic
Read 4 tweets
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Eric Topol
@EricTopol
Only 2 countries have given any approval to a #SARSCoV2 vaccine before there was clear evidence of safety and efficacy—Russia and China.
Now @SteveFDA has made it clear he intends US will be the 3rd. The man with no credibility saying that it isn't related to Trump's reelection.
It is f-ing outrageous to expedite *any* approval of a #SARSCoV2 vaccine, irrespective of @SteveFDA's subservience to Trump
We will not know about safety for many months after full enrollment. Some people may have serious untoward reactions (ADE or immune complex dz) when exposed
We will not know about efficacy for many months because it takes time and adequate statistical power to determine whether there is a difference in infection rates for vaccine vs placebo
thelancet.com/journals/lance…
Read 5 tweets

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