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New from us: The immunology of MIS-C v.s Kawasaki disease and acute COVID-19. Online now in Cell: cell.com/cell/fulltext/…
1/ Hyperinflammation in MIS-C differs from that of acute, severe COVID-19. Important info for therapeutic decisions.
2/ MIS-C differs from Kawasaki disease. Kawasaki involves strong IL-17A responses and high biomarkers of arterial damage etc.
3/ MIS-C produce comparable levels of anti-SARS-CoV-2 IgG as kids with mild COVID-19 w/o MIS-C. Preexisting immunity to common Coronaviruses lower in older MIS-C kids as compared to other groups. Relevance to disease unknown as yet.
4/ A number of candidate autoantibodies found elevated in MIS-C patients. Notable examples involve Casein-Kinase family members given recent report by @DoctorBou et al @KroganLab on upregulation of CSKII in SARS-CoV-2 infected cells: pubmed.ncbi.nlm.nih.gov/32645325/
Rapid team effort by colleagues @scilifelab @karolinskainst @KarolinskaUnsju @bambinogesu By an amazing group of talented friends: @consiglio_cr @pou_christian @LucieSTRod @LkanthTadepally Ziyang Tan @FabianSardh @CotwitNicola Nils Landegren and Paolo Palma and many more!!
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