Kai Kupferschmidt Profile picture
Sep 10, 2020 20 tweets 28 min read Read on X
“No disease in history has seen such rapid development in research”, says @DrTedros at @WHO presser on #covid19. “Now, the world's ambition to develop these tools as fast as possible, must be matched by its ambition to ensure as many people as possible have access to them."
@DrTedros @WHO Makes same point made he and @antonioguterres made earlier today at 1st meeting of facilitation council: That the ACT accelerator needs additional funding of $35 billion to develop and equitably distribute #covid19 diagnostics, therapeutics and vaccines.
@DrTedros @WHO @antonioguterres Role of the facilitation council is "to provide political leadership and advocacy and to mobilize additional resources”, says @DrTedros. High level event to be held at the United Nations General Assembly on 30th September, he says.
@DrTedros @WHO @antonioguterres “Every 40 seconds, someone somewhere dies by suicide”, says @DrTedros, acknowledging that today is #WorldSuicidePreventionDay. "Tragically, suicide is the second leading cause of death among 15 to 29 year olds."
@DrTedros @WHO @antonioguterres What to do? "restricting access to the means of suicide, including pesticides and firearms, building life skills, among young people that enable them to cope with stressors in their life, early identification, management and follow-up of people at risk suicide”, says @DrTedros.
@DrTedros @WHO @antonioguterres Q about Trump quotes on #Covid19 from Bob Woodward’s new book.
“I have no comment on that particular question”, says @DrTedros.
@DrTedros @WHO @antonioguterres Q about pause in Astra Zeneca vaccine study
Perhaps "a lesson for everyone to recognize the fact that there are ups and downs in research”, says @doctorsoumya. “We have to be prepared for those.” Says time to wait for determination by data safety and monitoring board now.
@DrTedros @WHO @antonioguterres @doctorsoumya “It is possible that we may start getting some results, at least interim results by the end of the year”, says @doctorsoumya on vaccine trials that started this summer. "However, you know, follow-up for safety needs to continue longer, but the minimum is six months."
@DrTedros @WHO @antonioguterres @doctorsoumya "It's a race against this virus. And it's a race to save lives”, says @DrMikeRyan on #covid19 vaccine “race”. "It's not a race between companies. It's not a race between countries. It's a race to support public health in the safest and most effective way possible."
@DrTedros @WHO @antonioguterres @doctorsoumya @DrMikeRyan Q why cases in Europe rising but deaths staying low
Combination of factors, says @mvankerkhove.
1. “We know so much more about this virus than we did in the beginning, so much more about how to find cases earlier, how to provide clinical care for cases depending on the severity."
@DrTedros @WHO @antonioguterres @doctorsoumya @DrMikeRyan @mvankerkhove 2. "we are in a better position to prevent the virus from infecting vulnerable populations”
3. Testing expanded, so finding more mild cases
"But I do think we need to be careful. … We still don't know the long term effects of this virus."
@DrTedros @WHO @antonioguterres @doctorsoumya @DrMikeRyan @mvankerkhove “We are connected together in a way for which there is no way back. Our countries are connected our people, our families”, says @DrMikeRyan. That connectedness has allowed the virus to spread. “We need to turn that connectedness back into our greatest strength.”
@DrTedros @WHO @antonioguterres @doctorsoumya @DrMikeRyan @mvankerkhove “What connects us allows the virus to spread. But what connects us allows us to stand together in the face of that virus”, says @DrMikeRyan.
@DrTedros @WHO @antonioguterres @doctorsoumya @DrMikeRyan @mvankerkhove “There are many people that are going through very very difficult times right now”, says @mvankerkhove referencing #WorldSuicidePreventionDay. “We're all in different situations and it's very challenging for all of us. But if you need help, please reach out.”
@DrTedros @WHO @antonioguterres @doctorsoumya @DrMikeRyan @mvankerkhove Q: 1/2 year tomorrow since @WHO called pandemic. How did it do?
@DrMikeRyan: “We have worked under the leadership of Dr Tedros every single day, every single night across our 6 regional offices, 147 country offices and with 194 member states to stand in the face of this virus."
@DrTedros @WHO @antonioguterres @doctorsoumya @DrMikeRyan @mvankerkhove “We celebrate the bravery of frontline health workers.
We stand with all of those people around the world who struggle to get by in this pandemic. It's very sad”, says @DrMikeRyan. “All of us, every citizen of this planet is tired."
@DrTedros @WHO @antonioguterres @doctorsoumya @DrMikeRyan @mvankerkhove “We're not in the same position we were in the beginning, countries have learned a lot”, says @mvankerkhove. "We have all learned a lot about what works in terms of suppressing transmission, in terms of saving lives."
@DrTedros @WHO @antonioguterres @doctorsoumya @DrMikeRyan @mvankerkhove "I think what we're seeing now is countries are trying to open up their societies and get back to this new normal that we all crave, that we all desire, applying these measures in a more localized way”, says @mvankerkhove
@DrTedros @WHO @antonioguterres @doctorsoumya @DrMikeRyan @mvankerkhove Q: Are any #covid19 vaccine trials using human challenge models?
"I do not believe that a protocol has been submitted for a challenge trial”, says @DrMikeRyan. “We're not aware of such a challenge trial having been initiated or started.”
@DrTedros @WHO @antonioguterres @doctorsoumya @DrMikeRyan @mvankerkhove Q to @DrTedros: What concerns you the most?
“What worries me the most is what I have been saying all along: A lack of solidarity. Because when solidarity lacks and when we are divided, that's a very good opportunity for the virus and that's why it's still spreading."

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More from @kakape

Jun 20
One question at the heart of the #h5n1 outbreak in US cows has been: Is there something special about this virus? Or is H5N1 generally able to do this and this particular version was just "in the right place at the right time"?
Quick thread, because it seems we have an answer
Researchers in Germany have done an experiment in a high-security lab infecting cows directly with the strain of #H5N1 circulating in cows in the US (B3.13) and infecting others with an #h5n1 strain from a wild bird in Germany.
(I wrote about the plans here: )science.org/content/articl…
In both cases they infected the udders directly through the teats and in both cases the animals got sick. They "showed clear signs of disease such as a sharp drop in milk production, changes in milk consistency and fever." That suggests there is nothing special about B3.13.
Read 8 tweets
Jun 13
The thing that I find most frustrating about the entire mpox/gain-of-function debate is how the uncertainties that lie at the base of it all just become cemented as certainties that are then carried forward.
(If you know anything about me you know I love me some uncertainty...)
Most importantly: The interim report on the investigation into these experiments released on Tuesday numerous times calls clade II "more transmissible" or even "much more transmissible".
But that is a claim that has very little evidence at all.
In fact you can find plenty of literature that argue the exact opposite, that in fact clade I is more transmissible.
Just, as an example, here is Texas HHS:
"Clade I MPXV, which may be more transmissible and cause more severe infection than Clade II..."
dshs.texas.gov/news-alerts/he…
Read 7 tweets
May 30
Some more details on the latest (3rd) human case of #H5N1 #avianflu linked to the current outbreak in dairy cows:
- second case in Michigan but not linked to the other case (different farm)
- reported cough and eye discomfort with watery discharge
- given oseltamivir, isolating at home
"As with the previous two cases (one in Texas, one in Michigan), the person is a dairy farm worker with exposure to infected cows, making this another instance of probable cow-to-person spread."
"The patient reported upper respiratory tract symptoms including cough without fever, and eye discomfort with watery discharge.  The patient was given antiviral treatment with oseltamivir, is isolating at home, and their symptoms are resolving."
Read 5 tweets
May 16
A thought on communication:
In today’s presser's opening statement @USDA presented work on killing H5N1 in ground beef through cooking. They mentioned no virus being present at 160°F and 145°F. Only later when someone asked, they mentioned that at 120°F there was some virus left.
@USDA I have thought a lot about trust and transparency in the wake of the #covid19 pandemic and to me this seems exactly the kind of communication style that does not build trust.
Yet another lesson not learnt in my book...
@USDA For reference, my thread on this:
Read 4 tweets
May 16
Researchers at @USDA have done a “ground beef cooking study” to test at what temperature #H5N1 in meat is killed. To be clear: Tests have found no H5N1 in beef samples, so this was done “in the interest of scientific inquiry and to further reaffirm consumer confidence”
@USDA So researchers added #H5N1 to ground beef patties then cooked them:
“There was no virus present in the burgers cooked to 145° [Fahrhenheit] internal temperature, or roughly medium, or 160°, which equates with a well done burger, which is the recommended cooking temperature”
@USDA At lower temperatures, some virus survived. "Cooking to I believe it was 120° [Fahrenheit] did show that there was virus still in the cooked hamburger patty, although at much, much reduced levels."
(But remember that these were experimentally infected burgers.)
Read 4 tweets
May 16
#h5n1 presser by @USDA and @HHSGov just ended. Had some some interesting bits (but what I would really love to see is still... serology):
@USDA @HHSGov - USDA researchers have done a “ground beef cooking study” to test at what temperature #H5N1 in meat is killed. To be clear: Tests have found no H5N1 in beef samples, so this was done “in the interest of scientific inquiry and to further reaffirm consumer confidence”
@USDA @HHSGov So the researchers added H5N1 to ground beef patties then cooked them. “There was no virus present in the burgers cooked to 145 degrees internal temperature, or roughly medium, or 160 degrees, which equates with a well done burger, which is the recommended cooking temperature”
Read 9 tweets

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