Kai Kupferschmidt Profile picture
Sep 10, 2020 20 tweets 28 min read Read on X
“No disease in history has seen such rapid development in research”, says @DrTedros at @WHO presser on #covid19. “Now, the world's ambition to develop these tools as fast as possible, must be matched by its ambition to ensure as many people as possible have access to them."
@DrTedros @WHO Makes same point made he and @antonioguterres made earlier today at 1st meeting of facilitation council: That the ACT accelerator needs additional funding of $35 billion to develop and equitably distribute #covid19 diagnostics, therapeutics and vaccines.
@DrTedros @WHO @antonioguterres Role of the facilitation council is "to provide political leadership and advocacy and to mobilize additional resources”, says @DrTedros. High level event to be held at the United Nations General Assembly on 30th September, he says.
@DrTedros @WHO @antonioguterres “Every 40 seconds, someone somewhere dies by suicide”, says @DrTedros, acknowledging that today is #WorldSuicidePreventionDay. "Tragically, suicide is the second leading cause of death among 15 to 29 year olds."
@DrTedros @WHO @antonioguterres What to do? "restricting access to the means of suicide, including pesticides and firearms, building life skills, among young people that enable them to cope with stressors in their life, early identification, management and follow-up of people at risk suicide”, says @DrTedros.
@DrTedros @WHO @antonioguterres Q about Trump quotes on #Covid19 from Bob Woodward’s new book.
“I have no comment on that particular question”, says @DrTedros.
@DrTedros @WHO @antonioguterres Q about pause in Astra Zeneca vaccine study
Perhaps "a lesson for everyone to recognize the fact that there are ups and downs in research”, says @doctorsoumya. “We have to be prepared for those.” Says time to wait for determination by data safety and monitoring board now.
@DrTedros @WHO @antonioguterres @doctorsoumya “It is possible that we may start getting some results, at least interim results by the end of the year”, says @doctorsoumya on vaccine trials that started this summer. "However, you know, follow-up for safety needs to continue longer, but the minimum is six months."
@DrTedros @WHO @antonioguterres @doctorsoumya "It's a race against this virus. And it's a race to save lives”, says @DrMikeRyan on #covid19 vaccine “race”. "It's not a race between companies. It's not a race between countries. It's a race to support public health in the safest and most effective way possible."
@DrTedros @WHO @antonioguterres @doctorsoumya @DrMikeRyan Q why cases in Europe rising but deaths staying low
Combination of factors, says @mvankerkhove.
1. “We know so much more about this virus than we did in the beginning, so much more about how to find cases earlier, how to provide clinical care for cases depending on the severity."
@DrTedros @WHO @antonioguterres @doctorsoumya @DrMikeRyan @mvankerkhove 2. "we are in a better position to prevent the virus from infecting vulnerable populations”
3. Testing expanded, so finding more mild cases
"But I do think we need to be careful. … We still don't know the long term effects of this virus."
@DrTedros @WHO @antonioguterres @doctorsoumya @DrMikeRyan @mvankerkhove “We are connected together in a way for which there is no way back. Our countries are connected our people, our families”, says @DrMikeRyan. That connectedness has allowed the virus to spread. “We need to turn that connectedness back into our greatest strength.”
@DrTedros @WHO @antonioguterres @doctorsoumya @DrMikeRyan @mvankerkhove “What connects us allows the virus to spread. But what connects us allows us to stand together in the face of that virus”, says @DrMikeRyan.
@DrTedros @WHO @antonioguterres @doctorsoumya @DrMikeRyan @mvankerkhove “There are many people that are going through very very difficult times right now”, says @mvankerkhove referencing #WorldSuicidePreventionDay. “We're all in different situations and it's very challenging for all of us. But if you need help, please reach out.”
@DrTedros @WHO @antonioguterres @doctorsoumya @DrMikeRyan @mvankerkhove Q: 1/2 year tomorrow since @WHO called pandemic. How did it do?
@DrMikeRyan: “We have worked under the leadership of Dr Tedros every single day, every single night across our 6 regional offices, 147 country offices and with 194 member states to stand in the face of this virus."
@DrTedros @WHO @antonioguterres @doctorsoumya @DrMikeRyan @mvankerkhove “We celebrate the bravery of frontline health workers.
We stand with all of those people around the world who struggle to get by in this pandemic. It's very sad”, says @DrMikeRyan. “All of us, every citizen of this planet is tired."
@DrTedros @WHO @antonioguterres @doctorsoumya @DrMikeRyan @mvankerkhove “We're not in the same position we were in the beginning, countries have learned a lot”, says @mvankerkhove. "We have all learned a lot about what works in terms of suppressing transmission, in terms of saving lives."
@DrTedros @WHO @antonioguterres @doctorsoumya @DrMikeRyan @mvankerkhove "I think what we're seeing now is countries are trying to open up their societies and get back to this new normal that we all crave, that we all desire, applying these measures in a more localized way”, says @mvankerkhove
@DrTedros @WHO @antonioguterres @doctorsoumya @DrMikeRyan @mvankerkhove Q: Are any #covid19 vaccine trials using human challenge models?
"I do not believe that a protocol has been submitted for a challenge trial”, says @DrMikeRyan. “We're not aware of such a challenge trial having been initiated or started.”
@DrTedros @WHO @antonioguterres @doctorsoumya @DrMikeRyan @mvankerkhove Q to @DrTedros: What concerns you the most?
“What worries me the most is what I have been saying all along: A lack of solidarity. Because when solidarity lacks and when we are divided, that's a very good opportunity for the virus and that's why it's still spreading."

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More from @kakape

Nov 1
So what have I learnt about #misinformation research? I tried to condense it into a list of the 5 biggest challenges the field faces.
Second story in my package of stories about misinformation research is up here (and thread to come):

science.org/content/articl…
Let me start with the first:
What even is misinformation?
When I started reporting on the field, eager to delve into things I was really frustrated that I kept coming back to this basic question. I told friends it felt like trying to take a deep dive in a puddle, always forced back to the surface.
In retrospect, it seems obvious that this was going to be a thorny problem that I would have to spend a lot of time on. The definition you use really defines the shape of the problem and it also kinda helps to be sure you're talking about the same thing as your interview partner...
Read 18 tweets
Oct 30
I’ve reported on infectious diseases for 15 years, but during the covid-19 pandemic and even more during the global outbreak of mpox clade IIb, I was shocked by the amount of misinformation I was seeing. Misinfo had always been part of any outbreak, but this felt different.
I ended up spending almost a year at MIT as a Knight Science Journalism Fellow (@KSJatMIT) to try and understand misinformation/disinformation better, to - I hope - be a better infectious disease journalist.
It’s been an interesting experience in turns fascinating and frustrating and when I went back to full-time science writing earlier this year I decided to try and put at least some of what I’ve learnt into words.
Read 10 tweets
Aug 15
I'm seeing a lot of confusion already out there about #mpox and the differences between clades and lineages. I will get into this in more detail later, but for now:
We really don't know for sure whether there is any material difference between clade Ia, Ib, IIa and IIb.
The differences we see might have very little to do with the virus and everything to do with it affecting different populations in different places and spreading different ways once it gets into certain contact networks. Real world data is not comparing apples and apples here...
We will learn a lot in the coming weeks and months and things will become much clearer. But for now there is a lot of uncertainty. My advice as always: Don’t trust anyone who pretends that things are clear and obvious.
Read 4 tweets
Aug 10
In May I wrote about researchers' plans to infect cows in high-security labs with avian influenza #H5N1 to better understand the infections and how easily the virus is transmitted. The results from two of these experiments are now out here in a preprint:
biorxiv.org/content/10.110…
WHAT DID THEY DO?
In one experiment (at Kansas State University) 6 calves were infected with an #H5N1 isolate from the current outbreak oronasally and then housed together with three uninfected animals ("sentinels") two days later.
In the other experiment (at Friedrich Loeffler Institut) 3 lactating cows were infected through the udder with an #H5N1 isolate from the US outbreak and 3 other lactating cows the same way with a different #H5N1 isolate from a wild bird in Europe.
Read 13 tweets
Jun 20
One question at the heart of the #h5n1 outbreak in US cows has been: Is there something special about this virus? Or is H5N1 generally able to do this and this particular version was just "in the right place at the right time"?
Quick thread, because it seems we have an answer
Researchers in Germany have done an experiment in a high-security lab infecting cows directly with the strain of #H5N1 circulating in cows in the US (B3.13) and infecting others with an #h5n1 strain from a wild bird in Germany.
(I wrote about the plans here: )science.org/content/articl…
In both cases they infected the udders directly through the teats and in both cases the animals got sick. They "showed clear signs of disease such as a sharp drop in milk production, changes in milk consistency and fever." That suggests there is nothing special about B3.13.
Read 8 tweets
Jun 13
The thing that I find most frustrating about the entire mpox/gain-of-function debate is how the uncertainties that lie at the base of it all just become cemented as certainties that are then carried forward.
(If you know anything about me you know I love me some uncertainty...)
Most importantly: The interim report on the investigation into these experiments released on Tuesday numerous times calls clade II "more transmissible" or even "much more transmissible".
But that is a claim that has very little evidence at all.
In fact you can find plenty of literature that argue the exact opposite, that in fact clade I is more transmissible.
Just, as an example, here is Texas HHS:
"Clade I MPXV, which may be more transmissible and cause more severe infection than Clade II..."
dshs.texas.gov/news-alerts/he…
Read 7 tweets

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