Prof. Akiko Iwasaki Profile picture
Sep 13, 2020 15 tweets 10 min read Read on X
I am the luckiest person in the world to have such wonderful trainees who organized the most amazing #IwasakiLabReunion/birthday zoom party yesterday. I am still in awe of how incredibly inspiring it was. Here are a few highlights I want to share with you. (1/) ImageImage
The event started with a delicious lunch delivered to my door for me and my family, to be followed later by my favorite dinner 🍣and 🎂 🍾 🎁 in the evening 😋 They really know how to spoil me! The entire day was packed with amazing talks, trivia sessions and Prince songs 💜(2/)
So 🙏🏼 to everyone who organized this incredible reunion and thoughtful presents - @maria_tokuyama @MelissaLV14 Kris Sepanek @jofrank1088 @JeffGehlhausen @Myoungjoo @peowenlu @carolilucas @aliceluculligan @tianyangmao @annsea_park @marioph13 @taka_takehiro @YYexin Pat Wong (3/)
The talented @YYexin drew this beautiful picture with my quote, “To be successful in anything, you have to enjoy it and enjoy yourself while doing it.” (4/) Image
What I found to be a common thread in all the amazing talks is that everyone is so resilient in their pursuit of their scientific quest. In their own respective labs, they found answers to long standing questions they began asking while they were still trainees. (5/)
For example, @EllenFoxman took 10 years to find the right experimental system to solve her question, “what is the basis of viral interference?” in this awesome study just published 👇🏽 (6/)

thelancet.com/journals/lanmi…
.@YosukeKumamoto took enormous effort to generate mouse models that allow conditional deletion of genes in his favorite dendritic cell type (CD301b+ DC2) to solve an inexplicable observation he made 7 years ago in this fantastic study👇🏽(7/)

biorxiv.org/content/10.110…
Just before leaving my lab to join Irv Weissman’s lab, @ImmunoFever told me how excited she was to test her hypothesis that CD47 (don’t eat me signal) may be induced on infected cells to regulate immunity. She published a paper showing just that! (8/)

pubmed.ncbi.nlm.nih.gov/32576678/
In 2012, @HShin_Lab observed that Prime and Pull reduced disease without affecting viral load in the vaginal mucosa after HSV-2 infection👇🏽 In her own lab, she figured out how disease is dissociated from viral load. Stay tuned for her publication. (9/)

pubmed.ncbi.nlm.nih.gov/23075848/
Carrying the torch to @fredhutch, @JennyLund15 continues to uncover new roles of #Tregs in immunity to genital herpes infection. Xinyan Zhao is now a president & CEO of Adept Therapeutics focused on cancer immunotherapy. Norifumi Iijima uncovering how adjuvant works. (10/)
Our current trainees gave fabulous talks, too! @weizmano on his new discovery of innate immune control of metastasis (pub in preparation), and @ericsongg on his study on neuron infection by #SARS_CoV_2 (11/)

biorxiv.org/content/10.110…
A surprise video of my dear friends, colleagues and role models giving birthday wishes to me. OMG 🤩😭 it made me soooo happy! I will cherish this forever… Thank you all 🙏🏼 (12/) Image
During the reception, we discussed the problems of toxicity and discrimination in academia. My dream would be to make changes so that everyone is given a safe environment to excel in science. As @aliceluculligan points out, science isn’t a zero-sum game! (13/)
The most gratifying revelation of #IwasakiLabReunion was that my former trainees, wherever they are in whatever profession, are spreading #kindness & #generosity to their own mentees. If I had anything to do with it, this is by far the greatest contribution of my career 🙏🏼 (End)
Oops how can I forget to mention Will Khoury-Hanold! Thank you Will!

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More from @VirusesImmunity

Mar 3
Delighted to share our latest work on #longCOVID - sex differences in symptoms and immune signatures. Led by @SilvaJ_C @taka_takehiro @wood_jamie_1 et al. with @LeyingGuan & @PutrinoLab. We find a striking inverse correlation btw testosterone levels and symptom burden👇🏼 (1/)

medrxiv.org/content/10.110…
This work leverages data from our recent Mount Sinai-Yale long COVID "MY-LC" study with the @PutrinoLab. This time, we asked the question, "Are there differences in symptoms and immune signatures of ♀️ vs. ♂️ with LC"? (2/)

nature.com/articles/s4158…
Image
While some symptoms were equally frequent in females and males, many were more frequent in females (e.g., swelling, headaches, muscle pain, cramps) than males. The top distinguishing symptoms of LC status by sex were hair loss in females and sexual dysfunction in males. (3/) Image
Read 16 tweets
Jan 13
In this prospective observational study, we examined changes in symptoms & immune phenotypes in vaccine-naïve people with #LongCovid after COVID-19 vaccination. Due to the timing of the initiation of this study, we were only able to recruit 16 people. However, the insights we gained are intriguing. Led by @connorbgrady, @bornali_27, @silva_JC, @hmkyale et al. (1/)
medrxiv.org/content/10.110…Image
This study was initiated in collaboration with @Survivor_Corps @dianaberrent based on their Facebook poll showing that 40% of respondents with self-reported Long COVID had mild to full symptom resolution after vaccination while 14% reported worsening of their symptoms. (2/)
doi.org/10.1101/2021.0…
In addition, evidence from other patient advocate groups, including @patientled and @longCovidSOS, and from @DanielGriffinMD, was emerging at the time on the impact of COVID vaccines in people with long COVID. (3/)
Read 19 tweets
Sep 25, 2023
So pleased to report that our Mount Sinai-Yale long COVID (MY-LC) paper with @putrinolab & others is now published!! Proud of the hard work of all who contributed. We found biological signatures that can distinguish people with vs. without #longCOVID (1/) nature.com/articles/s4158…
Question being asked: are there circulating cells & immune factors that are distinct in people with #longCOVID (LC) vs. those who recovered from COVID (convalescent control; CC) or those who never had COVID (healthy control; HC)? We studied 268 participants to address this. (2/) Image
Most participants were infected during the first wave in 2020, and studied on average about a year after the infection. Most were not hospitalized at acute phase and ~2/3 were female. We examined plasma factors, blood leukocytes & antibodies to SARS2, other viruses & self (3/) Image
Read 11 tweets
Aug 27, 2023
A short 🧵on a recent study by @MaggieLind2 with @MHitchingsEpi @datcummings Albert Ko et al. Data show that immunity induced by vaccines, prior infection or both (hybrid) protects against SARS-CoV-2 infection when viral exposure is low to moderate (1/)

nature.com/articles/s4146…
Question being asked: What is the risk of becoming *infected* with SARS-CoV-2 after developing immunity following a vaccine, prior infection, or both if exposure to the virus is very high, moderate, or low? They did not study the severity of symptoms. (2/)
How? The authors used the existing database of the Connecticut Department of Correction, where infection data based on high frequency of testing for SARS-CoV-2 on ~9300 residents across 13 facilities were available. (3/)
Read 9 tweets
May 5, 2023
A new study in @SciImmunology led by @AnisBarmada & Jon Klein @YaleIBIO with @lucasite_lab @InciYildirim11 @YalePediatrics teams explored immune signatures of people who developed myocarditis after mRNA vaccines. Here is what we found. 🧵 (1/)
science.org/doi/10.1126/sc…
Myocarditis is a rare adverse event that occurs most frequently in adolescent and young adult males after the second dose of mRNA vaccines. However, the underlying mechanisms remain unclear. (2/)

cdc.gov/vaccines/covid…
We considered three possible immune mechanisms of myocarditis.
1) Autoimmune/molecular mimicry
2) Hypersensitivity/eosinophilic type 2 immunity
3) Cytokine-mediated lymphocyte/macrophage activation
(3/)
Read 19 tweets
Mar 21, 2023
Very excited that our PaxLC clinical trial on #longCOVID patients is now open, led by @hmkyale! This is a phase 2, 1:1 randomized, double-blind, placebo-controlled research study in 100 non-hospitalized highly symptomatic long COVID. (1/)

clinicaltrials.gov/ct2/show/NCT05…
We will be providing paxlovid or placebo pills in long haulers for 15 days. The primary outcome will be measured by asking the patients to fill out some questionnaires pre & post treatment. We will find out whether their health changes with paxlovid vs. placebo. (2/)
Before, during, and after treatment, we will do a deep dive immune profiling to see if any changes are detected due to Paxlovid. We will apply a similar strategy that we used in our study with @PutrinoLab to understand the immune and viral signatures (3/)

medrxiv.org/content/10.110…
Read 10 tweets

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