Kai Kupferschmidt Profile picture
Sep 25, 2020 16 tweets 16 min read Read on X
"So-called lockdowns and the impact on global travel and trade have already taken such a heavy toll”, says @DrTedros at @WHO #covid19 presser. "The global economy is expected to contract by trillions of dollars this year."
@DrTedros @WHO "Many countries have poured money into domestic stimulus packages”, says @DrTedros. "But these investments will not on their own address the root cause of the economic crisis – which is the disease that paralyses health systems, disrupts economies and drives fear and uncertainty“
@DrTedros @WHO Today, @WHO and partners are publishing strategy plan and investment case for scale-up phase of the ACT Accelerator, says @DrTedros.
Aims to deliver
- 2 billion doses of vaccine
- 245 million treatment courses
- 500 million tests
to low/middle income countries by end of 2021
@DrTedros @WHO Current financing gap is $35 billion, says @DrTedros. "To put it in perspective, $35 billion is less than 1% of what G20 governments have already committed to domestic economic stimulus packages… It's roughly equivalent to what the world spends on cigarettes every two weeks"
@DrTedros @WHO Q: World is close to 1 million #covid19 deaths. Is it possible another million will die?
“One million is a terrible number and I think we need to reflect on that before we start considering the second million”, says @DrMikeRyan. "There is a lot that can be done to save lives."
@DrTedros @WHO @DrMikeRyan “Whether another million people die of #COVID19 is not a function of whether or not we have a vaccine”, says Bruce Aylward. "It's a function of whether or not we put the tools and approaches and knowledge that we have today to work to save lives and prevent transmission."
@DrTedros @WHO @DrMikeRyan Q: how to get especially young people to change behaviour?
Older people get this wrong, says @DrMikeRyan. "The vast majority of young people that I know are just as committed to containing this disease and saving lives as anybody else. In fact, more committed."
@DrTedros @WHO @DrMikeRyan “We have to see how we can support youth, like we support any sector in our society, to protect themselves and protect others”, says @DrMikeRyan. "I really hope we don't get into a sort of finger wagging... not a dialogue that is going to work, it certainly never worked with me."
@DrTedros @WHO @DrMikeRyan (Side note: For 9 months now I have been impressed by @DrMikeRyan’s #Covid19 communication. This is not about some kind of technical skill, his words are powerful because they are always informed by his humanity, by a will to understand not judge, to listen not talk.)
@DrTedros @WHO @DrMikeRyan Q about Africa and its success so far.
“We're not out of the woods anywhere and I would say we're not out of the woods in Africa”, says @DrMikeRyan. Lab capacity increased immensely, but "still many areas outside main cities where testing is not as good as it should be."
@DrTedros @WHO @DrMikeRyan "Africa has many lessons to teach the world about how to be resilient, how to be creative”, says @DrMikeRyan. "I have learned, side by side with many of my African colleagues on the front line and I guarantee you, I've learned more than I've ever taught."
@DrTedros @WHO @DrMikeRyan “Thing I've noticed over my career with colleagues who've been trained and worked in Africa, is that they immediately think about the community dimension as the first thing they think about not the last thing they think about”, says @DrMikeRyan.
@DrTedros @WHO @DrMikeRyan Q about resurgence in Europe.
“We are seeing in a number of countries right now, an increasing trend in cases. And part of that is due to the fact that we have better surveillance”, says @mvankerkhove. “But what is worrying to us is an increase in hospitalizations"
@DrTedros @WHO @DrMikeRyan @mvankerkhove Cases increasing fast in parts of Europe, says @DrMikeRyan. “We are seeing hospitals starting to have more occupancy, we're seeing ICUs beginning to have more occupancy, we're starting to see a small uptick in deaths in older people and that will inevitably become more.
@DrTedros @WHO @DrMikeRyan @mvankerkhove Lockdowns are last resort, says @DrMikeRyan. “To think that we're back in last resort territory in September, at the beginning of the autumn. I think that’s a pretty sobering thought. Have we really exhausted all of the tools, so we're back to lockdowns as a solution? "
@DrTedros @WHO @DrMikeRyan @mvankerkhove “We have to move fast”, says @DrMikeRyan. "I think Europe has as a lot of work to do right now to stabilize the situation and bring the transmission under some kind of control"

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More from @kakape

Nov 1
So what have I learnt about #misinformation research? I tried to condense it into a list of the 5 biggest challenges the field faces.
Second story in my package of stories about misinformation research is up here (and thread to come):

science.org/content/articl…
Let me start with the first:
What even is misinformation?
When I started reporting on the field, eager to delve into things I was really frustrated that I kept coming back to this basic question. I told friends it felt like trying to take a deep dive in a puddle, always forced back to the surface.
In retrospect, it seems obvious that this was going to be a thorny problem that I would have to spend a lot of time on. The definition you use really defines the shape of the problem and it also kinda helps to be sure you're talking about the same thing as your interview partner...
Read 18 tweets
Oct 30
I’ve reported on infectious diseases for 15 years, but during the covid-19 pandemic and even more during the global outbreak of mpox clade IIb, I was shocked by the amount of misinformation I was seeing. Misinfo had always been part of any outbreak, but this felt different.
I ended up spending almost a year at MIT as a Knight Science Journalism Fellow (@KSJatMIT) to try and understand misinformation/disinformation better, to - I hope - be a better infectious disease journalist.
It’s been an interesting experience in turns fascinating and frustrating and when I went back to full-time science writing earlier this year I decided to try and put at least some of what I’ve learnt into words.
Read 10 tweets
Aug 15
I'm seeing a lot of confusion already out there about #mpox and the differences between clades and lineages. I will get into this in more detail later, but for now:
We really don't know for sure whether there is any material difference between clade Ia, Ib, IIa and IIb.
The differences we see might have very little to do with the virus and everything to do with it affecting different populations in different places and spreading different ways once it gets into certain contact networks. Real world data is not comparing apples and apples here...
We will learn a lot in the coming weeks and months and things will become much clearer. But for now there is a lot of uncertainty. My advice as always: Don’t trust anyone who pretends that things are clear and obvious.
Read 4 tweets
Aug 10
In May I wrote about researchers' plans to infect cows in high-security labs with avian influenza #H5N1 to better understand the infections and how easily the virus is transmitted. The results from two of these experiments are now out here in a preprint:
biorxiv.org/content/10.110…
WHAT DID THEY DO?
In one experiment (at Kansas State University) 6 calves were infected with an #H5N1 isolate from the current outbreak oronasally and then housed together with three uninfected animals ("sentinels") two days later.
In the other experiment (at Friedrich Loeffler Institut) 3 lactating cows were infected through the udder with an #H5N1 isolate from the US outbreak and 3 other lactating cows the same way with a different #H5N1 isolate from a wild bird in Europe.
Read 13 tweets
Jun 20
One question at the heart of the #h5n1 outbreak in US cows has been: Is there something special about this virus? Or is H5N1 generally able to do this and this particular version was just "in the right place at the right time"?
Quick thread, because it seems we have an answer
Researchers in Germany have done an experiment in a high-security lab infecting cows directly with the strain of #H5N1 circulating in cows in the US (B3.13) and infecting others with an #h5n1 strain from a wild bird in Germany.
(I wrote about the plans here: )science.org/content/articl…
In both cases they infected the udders directly through the teats and in both cases the animals got sick. They "showed clear signs of disease such as a sharp drop in milk production, changes in milk consistency and fever." That suggests there is nothing special about B3.13.
Read 8 tweets
Jun 13
The thing that I find most frustrating about the entire mpox/gain-of-function debate is how the uncertainties that lie at the base of it all just become cemented as certainties that are then carried forward.
(If you know anything about me you know I love me some uncertainty...)
Most importantly: The interim report on the investigation into these experiments released on Tuesday numerous times calls clade II "more transmissible" or even "much more transmissible".
But that is a claim that has very little evidence at all.
In fact you can find plenty of literature that argue the exact opposite, that in fact clade I is more transmissible.
Just, as an example, here is Texas HHS:
"Clade I MPXV, which may be more transmissible and cause more severe infection than Clade II..."
dshs.texas.gov/news-alerts/he…
Read 7 tweets

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