Better late than never! (It's still Wednesday in some timezones!) This week's #SubfieldWednesday will be a bit briefer than normal.

#SubfieldWednesday (1/n)
Some of you might have been surprised last week when we described the hippocampal subfields as layered structures.

#SubfieldWednesday (2/n)
Even though the hippocampus sometimes gets grouped together with subcortical structures like the thalamus and basal ganglia, the dentate gyrus, CA fields, and subiculum are all part of a special type of cortex called the allocortex!

#SubfieldWednesday (3/n)
What the heck is the allocortex, you ask?

#SubfieldWednesday (4/n)
Remember that the human neocortex (most of what is commonly referred to as generic "cortex") is composed of six layers.

#SubfieldWednesday (5/n) Generalized scheme of corti...
The allocortex refers to the parts of the brain (including the hippocampus proper) that have only three layers: molecular, pyramidal, and polymorphic.

#SubfieldWednesday (6/n) Source: https://www.slidesh...
Now for a question to the subfield/anatomy fans out there! What about the entorhinal cortex? Is it allocortex or neocortex?? What about the perirhinal and parahippocampal cortices?

#SubfieldWednesday (end)

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More from @hipposubfields

11 Nov
Happy #SubfieldWednesday! After a two-week hiatus we are returning to our quiz about the mysterious transentorhinal cortex!

This quiz even stumped some of us at @hipposubfields headquarters! We had to contact a neuroanatomist to confirm which answer is correct! (or at least "the most correct")
Braak and Braak (1985) originally described the transentorhinal cortex as a 'transition region between entorhinal cortex and temporal isocortex. This rules out answer A (part of ERC) Figure 3. from Braak H, Bra...
Read 11 tweets
21 Oct
Last week we received over 100 (!) responses on our quiz about which hippocampal subfield accumulates tau pathology earliest in the disease.

#SubfieldWednesday (1/n)
This week we will explain that the correct answer for Alzheimer's disease (but not all types of dementia) is CA1!

#SubfieldWednesday (2/n)
Work from Braak & Braak (1991) showed that CA1 develops tau pathology before the other subfields.

#SubfieldWednesday (3/n) Cartoon drawing of the medi...
Read 9 tweets
2 Sep
Drum roll please...it's time for our very first #SubfieldWednesday!
One thing you might be wondering is: How many subfields are there in the human hippocampus and what are they called??

The answer actually depends on who you ask! Let me explain more!

#SubfieldWednesday
Most people who study the hippocampal subfields with high resolution MRI recognize CA1, CA2, CA3, CA4, dentate gyrus (DG), and the subiculum as the major subfields of the hippocampus.

That means there are five...right?

#SubfieldWednesday Image
Read 10 tweets

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