This is a followup to my thread yesterday to help the public understand better what is going on in Toronto (and Ottawa, Peel, and the rest of Ontario). I am going to focus on what everyone needs to understand about the ON testing fiasco (which is being played out elsewhere too)
First: I get my data from @jkwan_md@imgrund@JPSoucy@ishaberry2 to support my understanding. They get it primarily from publicly available sources, and make the data easy to understand.
Second: our daily case # in ON are artificially low (by ~330) because of the backlog.
The backlog was entirely preventable. I was told months ago when I asked that the reason labs weren't able to increase capacity was $$ from govt. @bruce_arthur covers this accurately here
Third: in July, we were catching no more than a quarter of active cases (we know this from data from @PublicHealthON who test blood samples donated/used for other things to see how many people were infected), and learning about it within 24-48h.
Even then, with few cases, we only knew where about half of people got their infection. Why? Because ppl were so socially active, it is hard to pin things down. Maybe other reasons. At least we were urging contacts to get tested also, to try and reduce them transmitting infection
But now, we are at a point where the majority of people being tested are going to be those who are symptomatic and willing AND ABLE to bother setting up an appointment. THIS WILL ARTIFICIALLY LOWER OUR NUMBERS BUT INCREASE TRANSMISSION BY THOSE WHO ARE PRE/ASYMPTOMATIC.
Fourth (🔑!): With expectedly lower numbers, this will have the effect of reassuring, well, everyone, that things aren't so bad. Additionally, because we are expectedly seeing a slower & lower rise of hospitalizations DUE TO COVID, it will give succor to the #casedemic morons.
Fifth: All this will have the expected effect of delayed action. The longer we don't act on breaking transmission cycles of a very contagious infectious disease, the size of the problem will grow exponentially (as it has). NOWHERE has this kinda growth abated w/o decisive action
NOTHING DONE IN THE PAST COUPLE OF WEEKS WILL RESULT IN A TRUE LOWERING OF CASES. As we do less interventions and testing, the no. of true cases will rise, not lower regardless of the official case number. What happens when you have lots of cases without awareness: US in Spring.
Melbourne 🇦🇺knew this and acted, Madrid 🇪🇸 didnt. Melbourne had unnecessary deaths, but emerged from their winter's darkness. We are behaving ~Madrid, which is now in lockdown, had 2400 ppl admitted to hospital the past week, w/ no end in sight. It doesn't have to be this way.
What does it take: 1. Personal responsibility to wear a mask, avoid unnecessary socialization/gathering (especially indoors) 2. Collective responsibility to say "Dumbass, don't go there--we have a COVID crisis" to your friends/family. 3. Govt. responsibility to act
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Yesterday, @COVIDSciOntario released updated treatment guidelines, focusing on patients with mild illness. It is a substantial change from prior guidance, so we thought we would walk people through the noteworthy changes.
First, as always, this is the work of +++people incl. the, er, volunteers of the Drugs & Biologics Clinical Practice Guidelines Working Group of @COVIDSciOntario. Co-chair is @MPaiMD.
Second, the update is a response to: 1. New data & evidence 2. Changes in drug supply & demand.
The first thing you will notice is that we have done away with Tiers (cue the cheers), and instead have put in a grid that takes a more nuanced approach to risk for disease.
[NEW] We are now aiming for treating pts whose risk of progression is comparable to ~5% hospitalization.
"W-w-wait! Paxlovid is NOT first line? I thought everyone was saying this is the best thing since the mute function!"
You have it right. If you look carefully at our guidelines on the 2nd page (where we cover outpt therapy for "Mildly Ill Patients") you can see where it lies.
"That is waaaay too small to see on my phone."
Sorry, let me try again.
"Oh, I think I can see. So Paxlovid is only for the highest risk patients, and only if they cannot get sotrovimab or remdesivir?"
That's right. And in Ontario, we don't have enough remdesivir for outpts.
Clinical Practice Guideline Summary: Recommended Drugs and Biologics in Adult Patients with COVID-19 - Ontario COVID-19 Science Advisory Table covid19-sciencetable.ca/sciencebrief/c…
The guidelines are based on a blend of pathogenesis, clinical trials, and local realities of drug supply and burn rate.
If we got it right, phew!
If we got it wrong, recognize that this is a rapidly evolving situation, with new evidence, new variants, and new drug availability.
Omicron has shortened the presymptomatic period, but we have little certainty of the rest of the time course.
I have received messages, texts, and reply-tweets regarding my stance on COVID management in ON (and elsewhere). As a strong early proponent of a #COVIDzero approach for a variety of reasons which, I believe, will show merit historically, I have never minimized COVID. However ...
1. I continue to have uncertainty regarding the severity of Omicron. I believe we will establish considerably more certainty in days ahead. Certainly, some evidence is emerging of a lesser severity—both mechanistically & epidemiologically—but I remain uncertain and thus cautious.
2. I don't accept the experience of the UK, Denmark, or anywhere else right now because they are at roughly the same time period in Omicron as we are—very early. The reasons why we cannot generalize from Gauteng are well documented, including in my weekly newsletter from Dec. 18.
1. The dominance of Omicron in cases means that the monoclonal antibody cocktail of casirivimab + imdevimab is no longer useful. It is sotrovimab or bust! 2. Because we don't have tons of sotrovimab, we are recommending it for the groups most likely to gain overall benefit.
These are symptomatic mildly ill patients who are:
70+ years with 1 additional risk factor
50+ AND Indigenous + 1 additional risk factor
Residents of LTC or other congregate care
Hospital-acquired
* other high-risk patients can also be considered (e.g. +++ immunocompromise)
1/ People are increasingly fed up with COVID, so measures to control Omicron cannot/should not rely on measures used for prior waves. (Which means that governments would be wise not to allow COVID to reach a crisis situation.)
When I highlighted several days ago that case growth was worrying me, several Twitterati assumed that I was alluding to lockdowns. (I was doing nothing of the sort)
But failure to pay attention to cases in EUR shows that countries can be forced into lockdowns if they don't act.
2/ Engineering/environmental controls (e.g. ventilation, filtration) will be the smallest imposition on people's lives.
Better masking (understanding, adherence, quality) would make a difference.
This is without assuming any properties of Omicron.