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5 Oct, 4 tweets, 2 min read
.@HallieJackson says Regeneron Chief Scientific Officer Dr George Yancopoulos coming up next with her on @MSNBC
@HallieJackson asks: What do you know about these 3 drugs together?

GDY: Our antibody cocktail essentially just mimics the normal immune system... theoretically there should not be any additional interactions with these other medications than you'd have with your own antibodies.
Yancopoulos also notes that bc Regeneron's antibody cocktail boosts the immune response, the concern about giving immunosuppressive dexamethasone earlier in course of disease may be lessened.
WOW: Yancopoulos tells @HallieJackson Regeneron has reached out to the Biden team to offer their antibody cocktail to them

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More from @megtirrell

Meg Tirrell Profile picture
8 Sep
AstraZeneca full statement here on clinical trial hold for its #COVID19 vaccine, scooped by ⁦@statnews⁩ statnews.com/2020/09/08/ast…
A few takeaways: it’s not clear what the issue is, if it will have a meaningful impact on AstraZeneca’s trial, or the trials of other #Covid19 vaccine makers.

(Though stocks are reacting at least in short term as if this is a boon for Moderna, Novavax etc)
Better takeaway here from @natashaloder, especially in this time of fear of a rushed vaccine:
Read 4 tweets
Meg Tirrell Profile picture
15 Jul
Dr Fauci, at an Atlantic event, was just asked about the criticisms coming at him from the Trump Administration:

Fauci: "It is a bit bizarre, I don't really fully understand it." (More)
Fauci on the list from Trump Administration circulated alleging what he got wrong on #COVID19: "If you sit down and talk to the people involved in that, they are taken aback by what a big mistake that was." (2)
Fauci: "If you talk to reasonable people from the White House, they realize it was a major mistake on their part bc it doesn't do anything but reflect poorly on them. I can't figure out in my wildest dreams why they would want to do that." (3)
Read 4 tweets
Meg Tirrell Profile picture
18 May
Moderna says it plans to start phase 3 #COVID19 vaccine trial in thousands of people in July, with phase 2 of 600 people expected to start soon (1)
Moderna’s plan to expedite clinical development of #COVID19 vaccine: start phase 2 with safety data from phase 1; phase 3 with safety of phase 2 + efficacy data from phase 1 to guide dose selection (2)
Moderna’s phase 2 #COVID19 vaccine trial will enroll 600 people and test doses of 50 and 100 micrograms; the planned high dose was revised (from 250 micrograms) based on phase 1 results (3)
Read 6 tweets
Meg Tirrell Profile picture
11 Apr
New open letter from Gilead CEO on remdesivir data: “We recognize the limitations of these compassionate use data from a purely investigational perspective, while knowing they are of the greatest significance for the patients whose symptoms improved. gilead.com/stories/articl…
Gilead CEO Dan O’Day: “The results, which cover 53 of the first patients to have been treated in the program, show that the majority demonstrated clinical improvement after taking remedesivir.”

Also notes 7 clinical trials initiated,data expected end of April in severe #COVID19
O’Day: “With every day that goes by, the desperate need to equip healthcare workers and their patients with a safe, effective treatment becomes more pressing. We are working with intense speed to determine whether remdesivir could be an option...”
Read 5 tweets
Meg Tirrell Profile picture
4 Apr
In new letter just posted, Gilead CEO says the company has ramped up remdesivir supply to 1.5 million individual doses (depending on optimal duration of treatment, which is being studied, could equate to 140K+ courses) which it’s providing to treat severe #COVID19 at no cost (1)
Gilead CEO Dan O’Day says company has set a goal of producing more than 500K treatment courses of remdesivir by October & 1M+ by year-end. Manufacturing remdesivir is a long process; O’Day says Gilead has reduced it from about a year to six months (2) #COVID19
Gilead CEO O’Day says doses of remdesivir are for treating #COVID19 patients w severe symptoms, daily IV infusions, in hospital setting. “Having a potential treatment in our hands comes with significant responsibility.” (3)
Read 7 tweets
Meg Tirrell Profile picture
19 Mar
Trump: We’re “slashing all of the red tape to get very important things to the market... medical.” Notes #COVID19 vaccine trial started this week, launched in record time. Pursuing antiviral therapies - “that’s the purpose of being up here today.”
Trump: “Doing great with the vaccines, but still a long process but therapies are things we can move on much faster, potentially. ... Looking at things to make people better or at the very earlier stages they wouldn’t even know they had it.” #COVID19
Trump: FDA Commissioner Stephen Hahn “is fantastic. He’s been working 24 hours a day, worked like probably as hard or harder than anybody in the group other than maybe Mike Pence, or me.” #COVID19
Read 26 tweets

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