Time for another takedown.

Today, it’s the editors of @NEJM for today’s editorial.
nejm.org/doi/full/10.10…
I will start with the references: 2 database queries, and 2 newspaper articles.

Definitely typical for an editorial in arguably the world’s top medical journal.
Regarding the arguments forwarded by the editors, we should first compare COVID rates of cherry-picked countries.

Should Canadians complain that their death rate is ~1000x that of Vietnam?
As Americans (I presume the editors of @NEJM are American), they should understand that—for better or worse, totalitarian approaches (like China’s) don’t work here.

And unlike New Zealand, we are not tiny, isolated islands.
First, was the early warning of SARSCoV2 ignored? As I recall, early travel bans were viewed as xenophobic.

Regarding testing, it should be justified *why* tests/infected person is a better metric (just cite). And was there really a lack of emphasis of developing capacity?
These arguments are either not understanding if American character (for better or worse) & it’s feeling towards “leadership”.

I would suggest no amount of “leadership” could herd us cats.

And regarding lifting of restrictions, how’s Europe doing?
Has the outstanding American expertise been uniform in their approach? I don’t think so.

Like all of us, we have muddled through as best we could, and tried to adjust when possible.

Have experts been ignored or denigrated? Maybe. Give some examples, because some deserved it!
For the Federal Government to run things, we needed to be assured they were right. In the setting of a novel threat, that’s poor risk management. We need experimentation to see what’s best—and some will not be great.

The key is to learn & adjust.
Regarding the CDC’s & FDA’s early testing failures, where does the blame lie? With the current administration? Or are they more institutional?

For the NIH, what does vaccine expertise mean for “government decision making”?

And if you have complaints, give some examples.
Are the editors claiming that COVID’s impact on minorities fed into this year’s protests?

And school closures—maybe ask @VPrasadMDMPH about that!

And last, while I can’t be precise, this editorial may have led to even more deaths than the Surgisphere paper.
Now, I don’t want to tell you know to vote for, but the current administration really sucks.

*WINK* *WINK*

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More from @AngryCardio

2 Oct
Now that folks have had a chance to digest the two reports on in-hospital cardiac arrest in COVID patients, let’s break them down.

Starting with the British study. bmj.com/content/371/bm…
First, a mea culpa.

Even though this study is published in the “British Medical Journal”, is is actually a cohort study in *American* hospitals. 🤦‍♂️
What did they do?

This group followed COVID patients sick enough to be admitted to intensive care units, and asked the following key questions:

1) How many had cardiac arrest?
2) What kinds of did they have?
3) What was done about them?
4) Any key differences?
Read 9 tweets
2 Oct
One thing I love about ET is that he identifies the best COVID studies.
These studies are looking at in-hospital cardiac arrest (IHCA) in COVID.

If you want to understand unique aspects of IHCA in COVID, who should you compare COVID arresters to?
In the British study (bmj.com/content/371/bm…) who were COVID arresters compared to? (Poll in next tweet.)
Read 10 tweets
27 Sep
Okay. A kind soul had sent me screenshots of @EricTopol’s thread explaining his letter to Pfizer.

I have highlighted a few sections, which I will comment on.
For those not familiar with the abbreviations, “DSMB” stands for “Data Safety Monitoring Board”. There are a couple of statements that deserve comment.

Here is a link to the @US_FDA guidance on DSMBs: fda.gov/regulatory-inf…
Here is a selection from the guidance.

Ask yourself this: In general, is a committee of 5 or a committee of 10-15 better for making decisions?
Read 13 tweets
26 Sep
I am definitely biased, but I trust the judgement of companies that have successfully developed vaccines over docs who by and large have little experience in drug or vaccine development.
I happen to know personally some of the signatories to the Pfizer letter. I respect their intelligence and honestly.

And I also know that they don’t understand what they signed, in that key underlying assumptions are at best questionable.
Okay, here is the letter. I have marked the key passages…
Read 7 tweets
25 Sep
According to ET’s piece in Science, “diffuse inflammation of the heart… that can extend throughout the three layers of the human heart to the pericardium… is a typical finding at autopsy after SARS-CoV-2 infections.”

Can anyone verify this—through literature or experience? Image
Thanks to @fitterhappierAJ, who tweeted this European autopsy series: academic.oup.com/eurheartj/adva…
Bottom line summary: lymphocytic myocarditis is rare, and there are many forms of heart injury. ImageImage
Read 5 tweets
24 Sep
Okay, I need a separate thread to talk about the figure in @EricTopol’s @ScienceMagazine Perspective article. Image
First Panel, SARSCoV2 & a heart cell. And an ACE2 receptor. Nice. Image
Second Panel: Some myocytes surrounded by inflammatory cells. I don’t recall reading about that…

Nice that they at least mentioned clot. Too bad they couldn’t show one. 🙄 Image
Read 4 tweets

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