Thread by @TristanRutland7

Bladder, adult female
 
@ZHOUSEH @MattieFarzin @rennmont @DrJPLow @ariella8 @RunjanChetty @JMGardnerMD @01sth02 @DrBMcGinn @s_prendeville @DrGeeONE @Dr_Brian_Cox @pembeoltulu @TheKarenPinto @kis_lorand @MarcosLepeMD
 
#GUPath #Surgpath #pathtwitter

SMA

ER PR

CD34

Also:

❌EMA

❌ALK

❌Pancytokeratin

S100 SOX10

Diagnosis:

Solitary myxoid neurofibroma.

#BSTPath

1/ Myxoid NFs are an uncommon variant (~10% of cases).
 
2/ Genitourinary NFs are also uncommon with the bladder being the most common site of involvement.

3/ There is no increased association with type 1 neurofibromatosis (NF-1).
 
pubmed.ncbi.nlm.nih.gov/17362838/

4/ Most NFs are solitary and not usually associated with NF-1, however ones occurring in deep soft tissue locations esp axial, can occasionally be.
 
5/ Check out the below article (look at the date!).
 
cancerres.aacrjournals.org/content/25/2/3…

6/ There are a number of variants of NF. Plexiform NFs are generally considered pathognomonic of NF-1 and have a risk of malignant transformation.

7/ Lastly, in the bladder (+/- female) a number of DDx could be entertained with myxoid morphology:

Examples include (and not limited to):
 
Rhabdomyosarcoma
Postoperative spindle nodule
Leiomyoma
Aggressive angiomyxoma
 
pubmed.ncbi.nlm.nih.gov/10564384/