1/ Interesting piece by @alexismadrigal and @yayitsrob on the current debate re rapid antigen testing for #covid19 epidemic control. As w/ anything, need to ask what the alternative is-- which largely is people not getting tested at all.
2/ They cite one critic who believes the answer is not to increase the supply of tests but to decrease the demand for those tests by improving other prevention measures, such as masking etc
Personally, I think it takes both of those things. Rapid testing is not simple...
3/ To actually implement. The more asymptomatic screening you do, the more false positives you will get (poor positive predictive value when population prevalence is low), & you need a confirmatory follow-up for those, or else risk the system collapsing.
4/ But, I think that rapid testing still can be operationalized especially for certain types of situations.
Unfortunately, as with Remdesivir, the Abbott rapid antigen tests were sort of just dumped on states w/o any actual plan for their distribution/use.
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While I actually believe the authors mean well, there are multiple reasons why I believe this is a seriously problematic proposition.
THREAD:
2/
-With asymptomatic & presymptomatic spread, the virus will inevitably find its way beyond the first layer of “healthy” people, esp in crowded households & intergenerational households— & especially in our most vulnerable communities who are more likely to run this risk.
3/
-Allowing millions of cases to spread unabashedly will absolutely mean at least several thousands of cases requiring hospitalizations. And those of us who are still working on the frontlines will be the ones — once again— fighting to care for patients w/o adequate supplies.
"One of American culture’s most cherished traditions is for a mix of young & old people from different households to sit close together & share food in a poorly ventilated space without masks on for an extended period of time. It’s called Thanksgiving."
1/ This was an excellent piece on the use of genomic sequencing to better understand #covid19 spread. One of the biggest challenges is understanding how and why spread is happening.
2/ @RanuDhillon and I wrote about this in @washingtonpost earlier this year-- genomic sequencing could provide a lot of this information. This helps to understand if x infected y, or if x and y both were infected separately. washingtonpost.com/outlook/2020/0…
3/ This has big implications.
For instance, if we found that cases in schools were largely happening from adults to children in the home, but not from children to other children in schools, it may change our calculus on school reopening.
1/ This is one of the best pieces you will read to put Trump's #covid19 infection into context.
As a physician, so much of what @edyong209 writes here resonates deeply, particularly that the language we use to describe disease is very problematic.
2/ While this is important in many ways, high filtrate masks are *most critical* for frontline workers who are regularly confronted with conditions in which aerosol spread can happen more easily.
3/ You know-- the frontline workers who literally kept this economy and this country afloat on their backs while those who were more privileged could safely "stay home".
These are some of our society's most vulnerable people; and they deserve to be *protected*