Of course another large cis-pQTL study gives us another opportunity to assess whether "closest gene is the causal gene" is true.
From the sup tables there are 75 primary cis-pQTLs. in 52/75 cases the closest gene encodes the protein being measured.
From the sup tables there are 75 primary cis-pQTLs. in 52/75 cases the closest gene encodes the protein being measured.
https://twitter.com/lassefolkersen/status/1317282331569377281
Another way of looking at the relationship between protein QTLs and the genes encoding the protein.
For the primary cis-pQTLs this coding gene is usually the closest gene (blue wedge). If not the closest gene, it's usually the second closest gene (orange wedge).
For the primary cis-pQTLs this coding gene is usually the closest gene (blue wedge). If not the closest gene, it's usually the second closest gene (orange wedge).
Interestingly, this is not completely true for the secondary cis-pQTL signals. Here the coding gene is more likely to be in first position than any other position but it's only true for 30 of 99 secondary signals.
I'd be interested in people's thoughts on this.
I'd be interested in people's thoughts on this.
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