Alina Chan Profile picture
26 Oct, 4 tweets, 3 min read
@AlexBerenson This is a question I've been asking as well. Where was RaTG13's data stored since 2018? Not in a public or password-restricted national database because even other Chinese groups only noticed the 99% match between SARS2 and the btCoV/4991 short sequence published in 2016 on NCBI.
@AlexBerenson Even scientists from the State Key Lab of Virology, Wuhan didn't have access to RaTG13 data (collected 2017-2018). In their Feb 5 paper, they lamented: "the BtCoV/4991 sequence was only partial and thus no comparisons can be made for the rest of genomes." tandfonline.com/doi/full/10.10…
@AlexBerenson Although the WIV publication that first named RaTG13 was put on bioRxiv on Jan 23, the raw data and genome sequence for RaTG13 were only deposited on a public database on Feb 13 and Mar 24, respectively. ncbi.nlm.nih.gov/nuccore/MN9965…
@AlexBerenson That means that up until that point, no one else appeared to have access to the RaTG13 data that had existed since at least 2017-2018 - as seen from the amplicon data (to fill gaps in the genome assembled from the raw data) quietly added to NCBI on May 19. ncbi.nlm.nih.gov/sra/SRX8357956

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More from @Ayjchan

25 Oct
Get ready. This is going to be an important thread. Election season will be over soon and hopefully more people will devote some attention to this...

I'm going to walk through a timeline of SARS2-related virus data published in the months after the outbreak. (1/30)
Since the outbreak in late 2019, events have been unfolding at such a fast pace that it is difficult to keep track of what happened and in what order.

I use visualizations of the timeline to follow key events relating to the search for the animal host of SARS2. (2/30) Image
Even today, I still hear people saying that SARS-CoV-2 came from pangolins and a Seafood market in Wuhan. I hope this analysis will help to clear things up. It will refresh us on significant early pandemic events and major publications discussing the origins of the virus (3/30). Image
Read 36 tweets
23 Oct
On masks: the experts are still debating whether masks reduce infectious dose of SARS2 (and, to a certain extent, transmission).

Data suggests that mask-wearing is likely correlated with less COVID prevalence in the area.
Pro-maskers are not pushing masks because of personal pleasure from making other people wear masks indoors. I personally hate wearing masks. But people are advocating for mask-wearing because it's quite possible that it protects against transmission.
Right now, you're right, we cannot distinguish the protective effects of masks (any type) from other public health measures.

But is this the war you want to fight?
Personally, it's more important to find out where SARS2 came from. Whether there's more where it came from.
Read 10 tweets
21 Oct
I need the scientists+editors who are directly or indirectly covering up severe research integrity issues surrounding some of the key SARS2-like viruses to stop and think for a bit.

If your actions obscure SARS2 origins, you're playing a hand in the deaths of millions of people.
I know it feels like your decision only impacts 1 publication or 1 genome. It's not.

Your decision helps bad actors to escape accountability and corrupt the public's knowledge on this issue.

Your decision makes this highly important research less transparent & less scientific.
If we don't fight to reduce pathogen spillovers into humans - whether natural or lab - it's a guarantee that more pathogens are coming from where SARS2 came from. People will find out some day and remember what top scientists and journals were doing to hinder investigations.
Read 29 tweets
20 Oct
Very glad that the paper by @MonaRahalkar and @BahulikarRahul is finally published in a peer-reviewed journal. We need more scientists and journalists looking at possible links between SARS-CoV-2 origins and the 2012 Mojiang miners. frontiersin.org/articles/10.33…
I know of experts don't want to consider the miners because it is too far out of, frankly, anyone's field. But if experts don't look at the miners because it is outside their specialization, and journalists don't look at them because of the complex science, then who will?
Apparently, the answer is semi-anonymous users on twitter, who have recently named themselves DRASTIC (Decentralized Radical Autonomous Search Team Investigating COVID-19).

Their findings were described in the Sunday Times (still behind paywall) in July. thetimes.co.uk/article/seven-…
Read 14 tweets
18 Oct
The RaTG13 genome was just quietly updated on Oct 13, 2020.

Why is this happening!?
ncbi.nlm.nih.gov/nuccore/MN9965…
I thought the sample disintegrated in 2018 after full sample sequencing was done (even though the Nature paper said it was sequenced post-COVID). What is there to update?!
Do scientists need to be assigned to just sit and watch these data depositions for RaTG13, pangolin CoVs, RmYN02 to see what new data accessibility or updates occur over the years?
Read 8 tweets
14 Oct
"The Guangdong (pangolin CoV) strains, which were isolated or sequenced by different research groups from smuggled pangolins, have 99.8% sequence identity with each other."

I wonder how that could happen!

nature.com/articles/s4157…
Let me clear this up. The same senior authors have repeatedly published this -singular- batch of pangolin samples. Did they actually isolate the virus in culture? If so, why not share this with other researchers worldwide? See details here: biorxiv.org/content/10.110…
Read 25 tweets

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