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Eric Topol Profile picture
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27 Oct, 4 tweets, 3 min read
I wish all these déjà vu reports of "disappearing antibodies" would disappear. That is not a problem.
directorsblog.nih.gov/2020/10/20/two… by @NIHDirector
nejm.org/doi/full/10.10…
@NEJM
See @florian_krammer's great thread explanation
Or this paper on the known knowns
jimmunol.org/content/early/…
Or you can read this 1st rate piece by @apoorva_nyc today
nytimes.com/2020/10/27/hea… w/ @profshanecrotty and @SCOTTeHENSLEY

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More from @EricTopol

Eric Topol Profile picture
25 Oct
Diagnosis: Uncontrolled spread
covidexitstrategy.org
1/
A ladder. Off the chart again with 83,000 new confirmed infections the past 2 days. Years from now people will look back and think how is this possible in the USA. Bleak? 2/
It doesn't have to be. We know we could achieve marked suppression by a universal mask mandate and aggressive non-pharmacologic mitigation measures. That doesn't have to equate to the "L" word. But timing is critical now 3/
Read 11 tweets
Eric Topol Profile picture
23 Oct
A new American pandemic record
83,010 cases reported today
@COVID19Tracking
Hospitalizations on a relentless rise
One week ago, there were concerns that the 3rd surge was manifest with highest cases since August.
Now highest cases in 2020.
Read 6 tweets
Eric Topol Profile picture
23 Oct
😷😷😷
In the next 4 months, 130,000 American lives could be saved by universal mask use, according to the new @IHME_UW forecast which gets us to >510,000 deaths by end February
@NatureMedicine nature.com/articles/s4159…
As compared with the status now:
"Mask use has emerged as a contentious issue in the United States with only 49% of US residents reporting that they ‘always’ wear a mask in public as of 21 September 2020"
Where people wear masks in the United States
covidcast.cmu.edu/?sensor=fb-sur…
Read 4 tweets
Eric Topol Profile picture
18 Oct
Almost the whole country is in the "Uncontrolled Spread" category covidexitstrategy.org 1/
The Upper Midwest and Sturgis, likely America's largest superspreader event
870 infections per million people in ND is an unprecedented peak in the US pandemic and around the world (2nd is SD/Czech Republic, currently 740) 2/
Like the #RoseGarden event, there was no contact tracing so the full extent of both these clusters will never be known
washingtonpost.com/health/2020/10… by @britsham @bylenasun
Deaths have risen sharply in ND, SD, MT 3/
Read 5 tweets
Eric Topol Profile picture
15 Oct
One monstrous wave, 3 phases, onto new heights, with no plan
A @nytgraphics explainer by @LaurenLeatherby
nytimes.com/interactive/20…
Hospitalizations tracking with infections
@COVID19Tracking
Read 5 tweets
Eric Topol Profile picture
14 Oct
What if Lilly's monoclonal antibody trial was stopped due to futility?
1. A pause at 300 patients after 5 days of treatment was pre-specified in the protocol
nytimes.com/2020/10/13/hea… by @KatherineJWu @katie_thomas Image
2. Trials have stopping rules for 3 main reasons:
—futility (further enrollment would not show benefit)
—safety (the intervention appears to have a hazard that precludes further enrollment)
—efficacy (the efficacy evidence is overwhelming and it would not be ethical to proceed)
3. Since the pause was pre-specified and Lilly announced a "potential safety concern," we don't know yet if it was for futility or safety. So far there have not been safety issues disclosed for the monoclonal antibody programs w/ now thousands of patients enrolled (Ab or placebo)
Read 6 tweets

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