1/ Re-upping this thread on the origins of #COVID-19. It makes a compelling case for a possible lab escape.

Magnitudes more plausible that SARS-CoV-2 emerged from a lab in Wuhan (known to be lacking in safety protocols) than from a 100% natural zoonosis.
3/ At what point will we hear a proper call for a true investigation into the suspicious inaccuracies and inconsistencies?

@c_drosten @trvrb @edyong209 @MackayIM @kakape @AdamJKucharski @mlipsitch @nataliexdean

Some have, but more voices are needed!

pnas.org/content/early/…
4/ How do you reconcile these facts and still not call for release of data & information that is being withheld by the Wuhan Institute of Virology, EcoHealth Alliance, NIH, China, and high-impact journals?

A thread:

5/ If these are the facts surrounding SARS-COV-2 origins, then in your revered opinion where this all leads to? Serious question…

@CT_Bergstrom @florian_krammer @gmleunghku @JeremyFarrar @profvrr @MarionKoopmans @PetrovADmitri @T_Inglesby @devisridhar @DFisman @neil_ferguson
6/ After a certain number of coincidences, it starts to look pretty damn suspicious. Evolution and undersampling just don't cut it anymore.

@michaelmina_lab @bealelab @maciekboni @drjenndowd @SaskiaPopescu @ras_nielsen @OscarMacLean1 @JeremyKonyndyk @cmyeaton @maiamajumder
7/ In light of all evidence, why are scientists shying away from addressing the core issues of SARS-CoV-2 origins?

@MRC_Outbreak @vanranstmarc @NAChristakis @TSutton_Lab @paimadhu @MarcBaguelin @dneafse @jennifergardy @PeterHotez @andrewpekosz @johnbrownstein @ChristoPhraser
9/End

Timeline of SARS-CoV-2 related virus data:

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More from @AntGDuarte

20 Aug
1. While awaiting @shingheizhan reassembling of RaTG13, here's a thread with some odd features reported by authors who made use of its GenBank sequence. Most of them used the sequence for other research goals, rather than assessing it, so its anomalies are mentioned incidentally.
2. This Feb 2020 preprint found that synonymous mutations "are dramatically elevated between SARS-CoV-2 and RaTG13" and "enriched in T:C transition."

Since some RNA mutagens "could induce the same mutation pattern", authors suggest further investigation.
biorxiv.org/content/10.110…
3. @Nerdhaspower's was the first paper I read raising doubts about RaTG13 sequence.
Issue: two bat CoVs show nonsyn mutations evenly distributed along their S sequences. For RaTG13 vs SARS-CoV-2 they appear heavily concentrated around codons 300-500. Why?

nerdhaspower.weebly.com/ratg13-is-fake…
Read 11 tweets

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