THREAD: I've been thinking about what causes the waves of COVID we've been seeing. A common explanation is weather or seasons. Eg, cold weather pushes ppl indoors in close contact. I want to explore another (economic) one: delayed reporting & prevalence response elasticity. 1/24
TLDR: A possible economic explanation for COVID waves, esp hi frequency or quick waves, is a/ delayed info about cases & b/ collective action problems. This explanation is not mutually exclusive w the seasonal explanation. @toxvaerd1 @tylercowen @ATabarrok @arpitrage @nebuer42 2/
It has implications. For science, policy: Plot longer run (months-long) moving averages to see what's happening w COVID. This may affect parameter estimation for epi models. For econ research: take seriously policy endogeneity if using time series to estimate effect of policy. 3/
Background: Waves are not unique to COVID. Famously, there were 3 waves of the 1918 flu (below, cdc.gov/flu/pandemic-r…). 4/
But waves are common in other pandemics (table below, cebm.net/covid-19/covid…). 5/
Now let's explore causes. Cause #1: A common one (from epidemiology) is seasons (below). It's consistent w/ data given prior pandemics waves spanned years not months. It makes common sense: ppl huddle inside when it's cold outside, spreading infection. 6/

hopkinsmedicine.org/health/conditi…
Of course, this plays out differently around the world. Eg, in Arizona, risk may peak during the summer when ppl come indoors for AC. In India, risk may peak during monsoons, when ppl come indoors to avoid rain. 7/

vox.com/2020/7/10/2131…

indianexpress.com/article/explai…
There may be other reasons why seasons affect infection other than crowding: eg, effect of temperature on viral particles, protective effects of sunlight/vitamin D, etc.

I do not dispute that seasons matter. I want to explore another, behavioral contributor. 8/
Cause #2: Delayed reporting & collective action problems. Let me explore these dynamics in turn. (Note, I;ve really folded 2 explanations into 1, but they stand independently as possible causes of relatively high frequncy waves.) 9/
a/ Delayed reporting: The intuition is the same as the problem of water temperature in a shower. If the water is too cold, you turn the temp knob up. But the heater responds w/ a delay. In the interim, you think you didn't turn the knob enuf. So you increase temp again. 10/
When the hot water finally gets to you, it's scalding. So then you turn the temp knob down. But you face the same problem on the way down. 11/
This happens with COVID. Cases are low to start. Society (govt + ppl) doesn't take it seriously, keeps up activity. Cases rise quickly. But delays in taking tests, getting test results, reporting results publicly mean society finds out with delay. 12/
Society engages in social distancing or suppression "too late". The negative effect on cases is immediate, but reporting is late. When it comes out, society relaxes, which raises cases. It relaxes for a while cuz it doesn't see cases except with a delay. The cycle repeats. 13/
b/ Collective action also contributes. Suppose there is no delay in getting COVID case counts. With collective action, even when I see cases rise, I may be slow to respond because I know you might curb activity protecting me, at cost to you but not to me. 14/
This can happen even with govt. Govt officials may wait thinking ppl will protect themselves. Ppl may wait thinking the govt will protect it. Again you get delay in action (even w/o delay in info). 15/
Policy: How do you solve this? a/ On delayed reporting: Get faster info on cases or base decisions on real-time "biomarkers" like mobility or google searches. It's not perfect cuz you have to know what mobility to "too high" or you wait for symptom searches. 16/
Plus there's error: biomarkers are convenient but imperfect measures. The errors themselves can create volatility in response. 17/

But any progress in reducing delay reduces amplitude of waves.
b/ Collective action, including by the govt. If you can solve this, we should just give you a Nobel prize right now. We have a list of other problems we'd like you to solve, e.g., climate change. ;) 18/
More srsly, this is a tough problem cuz even strict govt regulation is not sufficient. i/ It assumes harsh suppression is the right answer. It isn't always. ii/ Regulation is half the battle: enforcement is imperfect. That leaves room for individual variation in risk-taking. 19/
iii/ Regulation is hard to specify. Some activities are worth allowing even w rising cases (eg janitors at grocery stores). But it's hard to draw those lines well. Is it janitors at large grocers only, or also bodegas? 20.
Testing the theory: There's a way to test the delayed action explanation: test for waves in cases in locations w/ little seasonal variation in temps or crowding behavior. Think LA or San Diego. Or look for high frequency waves even w/in season in a place w seasons. 21/
For researchers: If the delay theory for waves has merit, there're ways that researchers can account it, whatever the cause. Eg, epi modelers could look at longer run moving averages of cases. Think of the waves of cases like fluctuations of stock prices around a price trend. 22/
If you fit that longer MA curve, you get different estimates of eg herd immunity threshold. W/o accounting for delays, you'd think you hit herd immunity w/ the first peak, and therein underestimate Rt, herd immunity, & implicitly beta/gamma. 23/
Help: I'm sure I'm not the first to point this out. If you read this and have references (even your own) let me know! 24/24 @satejsoman @sarahcobey @maciekboni @Noahpinion @EpiEllie @profmohanan @anuacharya @AnupamBJena @JustinWolfers @jonathangruber1 @skominers

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Anup Malani

Anup Malani Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @anup_malani

15 Nov
My 8th grade daughter (Uma) is writing an essay on the US Constitution for school. Her chosen topic is Federalist 10. Madison's warning about parties (below) is appropriate for our current times.
My daughter's concern is that it seems Madison's solution to factions, giving power to the Union (over the states), doesn't really stop parties and party loyalty.
But she agrees with Madison below: factions at the state level can harm a state, but not multiple states. Her solution (she is naive enough to think it is her solution) is more federalism.
Read 4 tweets
27 Oct
Thread: sample size calculations by economists.

Economists, esp in dev and health econ, are increasingly doing sample size calcs. It seems weird to do from an economics of info perspective.

Instead of calculating minimum sample size, we should report minimum detectable effect.
Usual sample size calculation requires calculating:

N = f(CI,study design,minimum detectable effect)

where CI is confidence. But economically this is telling you the cost you must incur (N) for a given level of quality (inputs into f, including MDE).
That has economic value, but is not really how studies are done or items are purchased. Consumers don't say, I have to have a car of this quality, just tell me what to spend. They see a vector of (quality, price) pairs & choose pair that maximizes U s.t. their budget constraint.
Read 12 tweets
25 Oct
I want to highlight this MR post by @ATabarrok. It has AFAIK a novel approach to trials that warrants serious discussion: release a drug & randomize access via lottery. Then compare outcome across ppl that won lottery and those who lost. Like the Oregon Health Ins Experiment.
If we do this, we may want to subsidize the price, so that demand for the lottery is high. This may also address ethical issues.

But there are some important issues with this approach. Not all insurmountable. Here is a first cut.
1/Selection. Ppl who are randomized to no access will get other treatment. Some will take nothing, others will take another conventional treatment if available.

But this is a problem with existing trials. I noted an old article on selection into RCTs.

sciencedirect.com/science/articl…
Read 9 tweets
25 Oct
On the multiple vaccine problem...

@Dereklowe argues that 1st EUA for a COVID vaccine will make it hard to recruit for other vaccine trials. @ht @tylercowen

There's a solution: PAY PARTICIPANTS TO ENROLL. (Thread.) @arpitrage

'The Vaccine Tightrope blogs.sciencemag.org/pipeline/archi…
I modeled & argued this in the 2019 J Human Capital paper below & a 2011 @nberpubs working paper (both w T Philipson).

journals.uchicago.edu/doi/abs/10.108…

nber.org/papers/w17011#…
@ATabarrok makes this point & offers more options on Marginal Revolution. marginalrevolution.com/marginalrevolu…

Can Medical Progress be Sustained? Implications of the Link Between Development and Output Markets
Read 25 tweets
18 Oct
Thread: Is the main benefit of a COVID vaccine health or economic activity?

Or: the counter-factual matters. What would we do in the absence of or delay in a vaccine?

Or: Let's replay the lives v. livelihood debate. But think about policy endogeneity. 1/20

@nebuer42 @arpitrage
TLDR: The value of a vaccine, & thus your distribution priorities, depends on the counterfactual. If CF is no/delayed vaccine & *suppression* (eg lockdown), main benefit of vaccine is economic activity. If CF is no/delayed vaccine & *no suppression*, main benefit is health. 2/20
In the former CF, you prioritize the most productive people. In the latter CF, you would prioritize people at greatest risk of health harm from COVID. 3/20

@oziadias @sarahcobey @maciekboni @pritika13 @sidrup @tylercowen @ATabarrok @neelkanthmishra
Read 20 tweets
10 Apr
CAN YOU HELP SLUMS WITH HANDWASHING?
This is an urgent request form NGOs working to stop COVID in Indian slums. Details of problem in THREAD. Summary: we need solution that slums can implement themselves w/ reused water. Please retweet to increase eyeballs. 1/
@vandanagoyal01
Handwashing requires water & soap. Both are in short supply in slums cuz they usually don't have water pipes. Govt sometimes sent water tankers, but those have slowed. 2/
@adamschilton @tariqthachil @adam_m_auerbach
We can't create new handwashing stations. This takes time to scale w/o a lockdown. With India's 21 day lockdown, definitely cannot ship them there. Plus, they require water. 3/
@pritika13 @nebuer42
Read 10 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!