This @WSJ Editorial Board piece, which has the jingoism of Rudyard Kipling's writings, deserves a fuller response. But in this thread I'm going to focus on one particular sentence in the opinion to help enlighten the thinking of our 'friends' at the @WSJ. on.wsj.com/2IZPlFC
That sentence is:

"It’s not clear developing countries even have the ability to manufacture large-scale, complex technologies like Moderna’s mRNA vaccine or Eli Lilly’s monoclonal antibody cocktail—let alone distribute them."
Putting aside the @WSJ's superiority complex, it's worth looking at some examples in the past where similar statements made by those in the western hemisphere about the scientific/technological abilities of countries in the global south have been proven wrong.
Case 1: In the 80s Merck and GSK had developed recombinant vaccines and held a monopoly with over 90 patents covering manufacturing processes. @WHO recommended every child be vaccinated but at $US23 a dose most Indian families could not afford.
Step in Shantha Biotechnics (later acquired by Sanofi). When the founder of Shantha approached a western firm for tech transfer, he was told: "even if you can afford to buy the technology your scientists cannot understand recombinant technology in the least". Image
Shantha went on to produce India's first home-grown recombinant product at $1 a dose. The vaccine was produced in a yeast system, the first of its kind for a commercial product, and different from that used in Merck and GSK's vaccines. bit.ly/3l6VFZD
Because of the $1 dose price, it enabled the low-cost mass vaccination through organisations such as UNICEF.
Case 2: When the avian flu crisis hit, Gilead/Roche drug Tamiflu was pushed as the first line treatment (later revealed to not be effective). Roche said it would be difficult for generic companies in India and the global south to synthesise the drug because of all the steps.
The @WSJ ran this back story in 2005 using language which questioned the claims of generic companies in the global south (nothing changes). I lived in India at the time and saw a Indian companies develop generic stockpiles of Tamiflu within months.on.wsj.com/39boKAK
Case 3: more recently with remdesivir, @GileadSciences said the the production is both resource and time intensive with some manufacturing steps taking weeks to complete. By July Hetero and Cipla were ready to dispatch generic versions bit.ly/3395Oi2
Having studied vaccine manufacturing capabilities in the global south on behalf of @gavi, contrary to earlier research and beliefs, what we found was IP issues, including patents, can be a barrier to preventing cheaper vaccines in the market place. bit.ly/3fpKdab Image
But the @WSJ is not concerned about the lives of people in these "poorer" countries, but more about maintaining a proprietary knowledge system that creates comparative advantage for a few countries.
And while recognising that mRNA technology hasn't been used before,@WSJ's statement about how "developing" countries may not have the ability to manufacture large scale complex technologies is the kind of scientific racism we saw in the days of imperialism. Time the @WSJ woke up.

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More from @realtahiramin

30 Sep
Despite what the CEO of Celgene/BMS has said in this hearing, it's important to note that even though Natco will enter with a generic version of Revlimid in 2022 it will be a very restricted amount.
The settlement between Natco/Celgene prevents Natco from fully coming to market until 2026. Other generics are still in litigation with Celgene BMS because of all the "important patent innovations" that Celegene piled up.
One of those "important innovations" is a patent on the crystalline form of lenalidomide which expires in 2027. A graduate student in organic chemistry would know how to get a crystalline form of a compound because it's just so obvious.
Read 4 tweets
30 Sep
The House Oversight Committee’s report on Celgene just dropped is a bombshell.

Internal strategy docs reviewed by Congress show that Celgene/BMS prioritised preventing “generic encroachment” and excluded competition by leveraging the U.S. patent system. oversight.house.gov/sites/democrat…
The report uses @IMAKglobal’s research to break down the details of Celgene/BMS’s patent abuse.

What is new are the insights we can take from the internal documents. Celgene knew the U.S. patent system could be manipulated, and they knew it gave them pricing control.
So, why, over 15 years, did their drug Revlimid go from $215 to $719/pill?

The report tells us what we already knew:

“pricing decisions...were driven almost exclusively by the need to meet company revenue targets and shareholder earnings goals.”
Read 4 tweets
29 Sep
Thread (1/14): Tomorrow, drugmakers will be testifying on the tactics the industry uses to prop up drug prices.

Let’s take a look at the story of a poster child of patent abuse: Celgene’s cancer drug Revlimid.
Currently, the list price for a 1-month supply of Revlimid is a staggering $22,314.

Revlimid is Celgene’s blockbuster moneymaker. In 2017, it brought in $8.1 billion — or 63% — of Celgene's revenue.

But, the real story of Revlimid starts back in the 1950s.
Revlimid began as the falsely proclaimed wonder drug Thalidomide, which was banished from the market in the early 60s after it was found to have devastating birth defects in the children of mothers who took it.
Read 14 tweets
6 Aug
Everyone in the #access2meds movement should see last week's tech hearings as a beacon. Monopolies have metastasized throughout our society thanks to a 40+ year economic agenda that has defined progress as giving power to a few. (1/5)
The hearings focused solely on tech, but just a peek at #pharma and one will quickly see the industry has all of the trappings of a monopolist’s candy store: widespread consolidation, the protections for perennial price increases, and most importantly...
...an antiquated patent system that provides pharma execs and their lawyer stonemasons the foundational bricks needed to fortify their revenue-generating “products” behind a facade of “innovation”.
Read 5 tweets
27 Jul
The U.S. govt signed a $2B deal to secure 100M doses of Pfizer’s #COVID19 vaccine candidate. This deal is extremely troubling and I’ll tell you why...
At the end of the day, our market-based drug dev system is built around the requirement to deliver shareholder value and profit. Despite what their PR teams tell us, drugmakers are not intrinsically motivated to ensure equitable access to a vaccine.
Drugmakers are controlled by a system that they themselves designed, which mandates they prioritize ROI over equitable access.
Read 5 tweets
30 Jun
Like their request for orphan drug status, just can't help but make a stink by charging $3,120 for remdesivir.
To add insult to injury, CEO Daniel O’Day says, “I’ve never seen a disconnect between doing what’s right for patients and doing what’s right for investors”. Easy to say when your annual compensation is $16 million. bit.ly/2CLIwV4
Making people pay excessive prices for a drug their tax $ developed is a disconnect. Making sole claims to patents and locking up knowledge that was invented with public $ is a disconnect. Pricing a pandemic treatment at 10x the cost-effective benchmark price is a disconnect.
Read 4 tweets

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