This is actually an excellent point that is not made often enough. Most vaccine trials are done over years, so they have smaller numbers because more people get infected. The COVID-19 trials are VAST
https://twitter.com/dfreedman7/status/1331699376419459072
We won't pick up on any long-term side-effects that only take place after 6-12 months, of course, because of the shorter time frame
Still, the trials are pretty amazing
Still, the trials are pretty amazing
Worth noting here that when I say "long-term" I really mean "only diagnosed after 6 months". By the time vaccines are rolled out, we'll have at least 6 months of follow-up data so anything that you'd expect to be picked up in that time-frame should show some signal
The real worry is chronic diseases that take years to be diagnosed, but that's not the same as serious chronic issues that start immediately after vaccination (which is what people often worry about)
And this sort of problem tends to be incredibly rare in terms of vaccines. I actually can't think off the top of my head of an example, although I'm sure they exist. Anyone?
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