Been in research for 12+ years and can say that the inability to reproduce a considerable amount of work published even in high IF journals has real costs - to scientists' careers, the research ecosystem, and taxpayers who are ultimately paying for the vast majority of research.
Research publishing can be compared to a game of bluff, where the biggest winners are not necessarily the most honest. But in research, there's no reward for calling someone's bluff, which can likely drag you through years of hell, stalling your own career.
In order to retain scientists who do good science, we need to reward good science.
As some covid publications have highlighted, data+protocol sharing and study reproducibility are not enforced even at basic levels by even top journals.
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Great article by @sciencecohen
"Not urgently needing the vaccines at home to fight a virus it has largely quashed, (China) is playing a global game.. using the vaccine to promote the diplomacy of foreign policy objectives." sciencemag.org/news/2020/11/g…
In-depth discussion of China vs the West's vaccine approaches: which can induce broader immunity, is easier to manufacture and distribute, has the risk of antibody-dependent enhancement of covid, and, importantly, can be readily manufactured locally in other countries...
"crucially for China’s vaccine diplomacy, many.. countries have manufacturers that have produced inactivated virus vaccines for decades.. (those) that cannot access vaccines bankrolled by Warp Speed—especially those that hosted China’s.. trials—might have a more secure vaccine.."
A lot of interest in the D614G mutation comes from whether it made SARS-CoV-2 significantly more challenging for other countries, including Europe and the US, to stop the spread of the virus compared to when it first emerged in China.
For instance, Malaysia's Health Ministry Director infamously said that the D614G variant is 10x more transmissible.
Even though D614G was also present in China in January. See thread:
Two peer-reviewed papers were just published discussing D614G and whether more transmissible variants of SARS-CoV-2 have emerged since late 2019: cell.com/cell/pdf/S0092…
Also people asking me about this @nytimes article about Dr. Limeng Yan, Steve Bannon & Miles Guo.
My stance has not changed. We need a way for whistleblowers to get out of China without Bannon and Guo standing in their way and damaging their credibility. nytimes.com/2020/11/20/bus…
My original thread response when Dr. Yan released her first preprint is here: "If there is one thing that this entire saga has made clear - it is that whistleblowers (as it pertains to SARS2) have no obvious safe route of sharing their information."
For those who aren't too familiar with Dr. Yan's story, here is a quick summary:
In Jan 2020, Yan was helping her supervisor to investigate the new covid outbreak. She heard rumors about the dangerous new virus that the Chinese gov was playing down, and blew the whistle...
First, kudos to the article: "Strong evidence suggests that SARS-CoV-2 originated in horseshoe bats, but whether it passed directly from bats.. or.. an intermediate host, remains a mystery."
Scientific consensus is that bats are the ultimate source. But how did it get to Wuhan?
The Cambodian virus from 2010: "The virus’s genome has not yet been fully sequenced — nor its discovery published — making its full significance to the pandemic hard to ascertain."
How can scientists address questions that have been painted as conspiracy theories? And without amplifying or legitimizing misinformation related to these questions.
As a scientist who has been washed out to sea on a contentious covid topic, I find it safest to talk to science journalists for news articles - professionals with some extent of scientific training, who know what to ask scientists, how to probe their reasoning and evidence.