Thread by @BadgleyLaurence

MCAS ALARM SYSTEMS: etiology & treatment speculations. The idea that there might be primary causations of Mast Cell Activation Syndrome (MCAS) raises interesting ideas for treatments.

Human bodies have certain tissues that warn of danger. Ligaments pulled asunder result in inability to walk & run so stretched ligaments hurt. Infections cause acidosis & death; arousing protective white cells. Nerves sense dangers of heat & pressure and signal pain.

Mast cells release histamine, which in occasional & moderate amounts can promote & participate in the healing physiological process called inflammation. Inflammation announces that the body is attempting to heal.

Primary tissue stretch elicits neural stretch, which has been recently shown to evoke mast cell degranulation. Mast cells are activated by excessive tissue stretch (Wang et al, 2010).

Physiologists know that mast cells and nerves touch/communicate, & that stretched tissues elicit mast cell activation. Because of estrogens, women have more elastic soft tissues than men, so it is expected that they would have more mast cell activation.

Therefore, connective tissue mobility, neural stimulation, & Mast cell degranulation are intertwined. Each system interacts with the others to guard against bodily threats.

My encounters with persons who have Mast Cell Activation Syndrome (MCAS) have impressed me these people are often older, & their Hypermobility tissue status can sometimes only be recognized by specific historical information.

As humans age they become less flexible. We turn to stone. The tone of aging people often falters. Often processing of restorative nutrients might become problematic.

I have considered that MCAS is a process that takes time to evolve; so that it seems to more greatly affect older than the younger. But there are few certainties in clinical medicine. All phenomena have a spectra of manifestations.

The skin, nerves, connective tissues, & specialized immune cells, the Mast cells, seem to be sentinels guarding body portals (eyes, nose & GI system) against invasion of germs, foreign substances, & even fumes.

Mast cells release histamine, which brings greater amounts of healing blood & tissue juices into body sites whereat the body senses tissues being assaulted.

Assuming that degranulation of Mast cells represents overactivity of a protective mechanism, what solutions might be offered to modify the hyper-vigilance of Mast cells.

My regard is that Mast cells’ hyper-reactivity is a defense against assaults of the body, especially foreign substances like allergens. It takes repeated exposures for antigens to arm the allergic systems; to arouse immune/hormone defenses.

Dry eyes and nose suggest that perhaps repeated assaults have worn down mucous membrane protection mechanisms. With repeat exposures, histamine surges can even result in anaphylaxis & loss of consciousness.

Connective tissues that began life as hypermobile, as genetic variations, can become even more greatly loosened by mechanical forces of multiple birthings, & by strenuous & injurious physical activities.

Some speculation might be given to abundance of estrogens given to women since dawn of birth control pills (late 1960’s). Certainly Endometriosis seems to be more prevalent in recent years, & MCAS might have some relationship to the evolution of Endometriosis.

Pervasive estrogenic chemicals exist in plastics. Some scientists have calculated that the average human consumes a credit card equivalent of plastic each week. Water should be stored in and consumed from glass.

If, as tissue scientists tell us, Mast cells degranulate when tissues are hyperextended, then a simple solution might be to stiffen tissues of the upright body tower. How can this be undertaken?

One variable is weight. There needs to be a healthy weight to height ratio, & if too great then a KETO diet needs initiation. Excess weight strains a body tower already loose with hypermobile connective tissue; especially if muscles are not well toned.

A key therapeutic effort might be to stiffen the upright body tower. In my threadreader of 11/15/2020, I discussed a gentle program for reconstituting stiffness of the upright body tower by progressive muscle development in water & then on land.

A stiff body tower is the natural way to forestall hyper-elastic effects of connective tissues & activation of Mast cells, which degranulate when these tissues stretch.

Men have easier capability of bulking up their muscle. A woman who might want to exceed the lesser muscle development common to women might study the use of gentle intermittent Testosterone boosts, but only under doctor guidance.

Certainly, a common phenomena these days are women transiting to male gender morphology, and they do this with help of Testosterone. Another method might be gentle bursts of Growth Hormone; again only under doctor supervision.

Of course these uses of hormones are not without side effects & unexpected consequences that attend any experimental therapy. As with all therapeutic efforts, the risks must be balanced by the benefits.

Different people experience Mast Cell Activation Syndrome (MCAS) with different symptom constellations & with various symptom intensities. Each person needs to decide for themselves what risks they are willing to take to abort symptoms.

There is another therapeutic consideration that includes nutrition. Heated & unrefrigerated fats become peroxidized (rancid). When these fats are taken into the body they can become incorporated, as fats are want to do, into cell membranes of many body cells.

Cells that have greater ratios of cell wall peroxidized fats, like arachadonic acid, are more prone to degranulate histamine in response to allergic antigen exposures. One way to diminish peroxidized cell wall fats is not to eat them.

Another way to diminish peroxidized cell wall fats might be to consume generous amounts of free radical scavengers like Vitamin C, Vitamin E, grape pigment extracts, & other antioxidants:

Some of the natural pigment antioxidants studied for cell protection include curcumin, lutein, lycopene, beta-carotene, betalain, capsanthine & cyanidine-3-rutinoside. See my recent tweet about data for natural pigments.

Assessment of free radicals scavenging activity of seven natural pigments and protective effects in AAPH-challenged chicken erythrocytes - PubMed

Chromolyn can be taken internally & in eye drops; in attempt to stabilize mast cell walls; to prevent histamine degranulation. Once histamine has been released, over the counter anti-histamines are effective. The natural substance Quercitin has Mast cell wall stabilizing effects.

CONCLUSION:
Persons with connective tissue Hypermobility are prone to Mast Cell Activation Syndrome (MCAS), a non-infectious process. There are natural ways to stiffen the body, & to use natural substances to possibly reduce Mast cell degranulation of histamine.

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