During a #COVID19 lecture, I often get this question: “How do we reach herd immunity when there’s so much vaccine skepticism?” The number willing to be vaccinated appears well below the target threshold (~70%) to get back to normal life.
Here’s what I say: 1/
First, I try to meet skeptics where they’re at. That begins by acknowledging a few things:
1. The National Vaccine Injury Compensation Program exists for a reason.
2. The leading #COVID vaccine platforms are new and we don’t have long-term safety data.
3. Emergency authorization will likely curb manufacturer liability.
4. Vaccines have been rushed in the past (influenza, 1976) & the result wasn't good.
5. We don’t know how long protection will last or whether the shot will be a yearly thing (jury’s still out on antigenic drift)
6. It is completely reasonable to be unsure about an experimental vaccine.
Then I shift gears and explain what the past ten months have been like in the hospital. How it began with a cluster of patients with flu-like illness in February who didn’t have the flu. How those numbers swelled and our ICUs quickly filled up with patients...
with severe, life-threatening COVID.
How it’s happening again. 
I explain what crisis standards are and what rationing of medical care means for people—even those without COVID—and how the collapse of a healthcare system reverberates beyond the walls of a hospital.
Then I turn to COVID vaccines and discuss what they seemingly can and cannot do. They will not make the virus disappear and they may not prevent transmission, but they appear extraordinarily good at protecting people from severe disease. This matters.
I also mention that I fully support the vaccines we currently give patients & I have tremendous confidence in the Vaccines and Related Biological Products Advisory Committee (VRBPAC) that is meeting on December 10 and 17 to publicly review data. This is transparency at its best.
I conclude with a simple thought: My job is to look people in the eye and tell them that something is safe & effective. The early news from vaccine studies fills me with hope that I’ll soon be able to do that. Until then, I understand why people are skeptical. I’m skeptical, too.

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More from @DrMattMcCarthy

2 Dec
Giving a lecture at @NYUStern tonight and students were asked to submit questions. A theme has emerged: "How do you get people who are emotionally exhausted by coronavirus to take precautions seriously?"
A few thoughts: 1/
If you really want to engage someone, you have to know their point of view. For me, this means going down some truly gnarly rabbit holes of misinformation. (I know the case against masks inside and out). Occasionally, I hit on something interesting. This happened the other day...
...when a staff writer from the @NewYorker pushed me on the origins of coronavirus. I've trapped bats with some of the scientists featured in "Spillover" by @DavidQuammen and for most of this year, I have been of the opinion that #coronavirus leapt from animal to man.
Read 7 tweets
30 Nov
Here's an advance that would mean a great deal to the more than 30 million American adults with hearing impairment: the FDA must establish a new class of over-the-counter hearing aids.
Masks and social distancing can be a challenge for those with hearing loss & aids are often 1/
prohibitively expensive and not covered by insurance. In 2017, the bipartisan Over-the-Counter Hearing Aid Act gave the FDA 3 years to propose regulations governing over-the-counter hearing aids but the pandemic derailed the timeline. A statutory deadline was missed in August. 2/
The FDA has a lot on its plate but this story should not get lost in the shuffle. It is a straightforward process that could improve the lives of millions.
Over-the-counter hearing aids are already available in other countries.
nidcd.nih.gov/health/over-co…
Read 4 tweets
28 Nov
Vitamin D is in the news today because: 1) England is giving it out for free and 2) This article minimizes its role in the pandemic. But there are some very smart people who think it is not just important for #COVID19 but essential. Here's how the argument was presented to me: 1/
Many of the chronic diseases identified as #COVID19 risk factors (high blood pressure, diabetes) are potentially associated with vitamin D deficiency.
pubmed.ncbi.nlm.nih.gov/20031348/
D deficiency is associated with increased risk for some respiratory infections. In one study, people with low levels were more likely to have had a respiratory infection in the month before having their blood drawn compared to people with normal levels.  
pubmed.ncbi.nlm.nih.gov/25781219/
Read 8 tweets
27 Nov
You've heard the refrain: "We want to see the data." But what does that mean? Here are some of the things we'll be looking for when a federal advisory panel meets on December 10th to discuss emergency authorization of a #COVID19 vaccine: 1/
1. Are there assurances that subjects were not inadvertently unblinded? Participants & doctors shouldn't know who received placebo, but one can occasionally make an educated guess. (Unblinding occurred during an HIV trial when the drug changed red cells):
virusmyth.org/aids/hiv/jltri…
2. Tell us more about the patients who developed symptoms in each group: How many were hospitalized? Required oxygen? What's the age breakdown? How many had chronic medical conditions?
Read 6 tweets
26 Nov
Editing a #COVID19 guidebook for doctors. It's intended for those with little or no experience treating coronavirus. What should it tell them about prone positioning? (Prone = the patient lies flat on their chest instead of their back). 1/
Prone positioning works for some diseases, but not all. It improves oxygenation in patients with severe acute respiratory distress syndrome (though more homogenous ventilation) & may decrease lung injury. Some suspect it might help patients with COVID. 2/ pubmed.ncbi.nlm.nih.gov/23688302/
But there aren't any randomized controlled COVID trials to answer this question (yet). Instead, we have smaller, cohort studies suggesting prone positioning could be helpful in certain patients. 3/ ncbi.nlm.nih.gov/pmc/articles/P…
Read 5 tweets
24 Nov
Asked by an interviewer today if there's anything that haunts me from the first wave of #COVID & what lessons we can learn from it. Those who've heard my lectures know I could do an hour on this, but the thing I keep coming back to: It took a long time for us to use steroids. 1/
The problem: Doctors are trained to practice 'evidence-based medicine'. When the disease is new, there's an evidence vacuum. We didn't have *any* reliable data in early March. How do you make life-or-death decisions without evidence? 2/
One way to look at it: If the intervention is relatively harmless, it's not a big deal to go out on a limb. (Want to try zinc? Go for it!). But steroids aren't harmless. There was a genuine concern that they could make things worse for COVID patients based on our experiences...3/
Read 5 tweets

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