Thread by @drmusanordin

The politics aside, there is some truth in KuLi statement that the Pfizer mRNA vaccine “bukan benar-benar menghalang penularannya”
The primary objective of the Pfizer study was to evaluate the safety and efficacy against COVID-19 in healthy persons.
pfe-pfizercom-d8-prod.s3.amazonaws.com/2020-09/C45910…
1/10

https://twitter.com/501awani/status/1335794005657808897

It was not designed to study the transmissibility of the virus post-vaccination.
Allow me to share an analogy related to the issue
Previously our pilgrims were mandated to take the Meningococcal Polysaccharide Vaccine (MPV) prior to their Hajj @drzul_albakri @imamalaysia 2/10

The MPV protected the pilgrim from Invasive Meningococcal Disease (IMD) but they are still able to transmit the disease to others around them since the MPV did not clear the bacteria from their upper airways @drzul_albakri @imamalaysia @FIMAweb 3/10

When the first Meningococcal Conjugated Vaccine (MCV) was available in Malaysia, I presented to select members of the Majlis Fatwa Kebangsaan (MFK) on the superiority of the MCV since it prevented both the vacinee and others around him from IMD @drzul_albakri @imamalaysia 4/10

The MCV eradicated the bacteria from the upper airway and conferred indirect protection to persons around the vacinee.
I hope this will now convince the LUTH and all pilgrims to take the MCV instead of the old MPV @drzul_albakri @imamalaysia @FIMAweb 5/10

Back to COVID, thus far only researchers at Oxford, using the viral vector #AstraZeneca vaccines have hinted that testing showed the vaccinated group in UK had fewer asymptomatic infections, which means they’d be less likely to spread the disease @drzul_albakri @imamalaysia 6/10

I am hopeful that mRNA #CovidVaccines will have some effect on transmission based on 3 plausible mechanisms:
1. If particles breathed out by asymptomatic/pre-sym cases during talking & breathing transmits the virus, then a vaccine that reduces symptoms wud also reduce spread 7/10

2. The mRNA #CovidVaccines by reducing a person’s viral loads in the upper airway also cuts the amount they can transmit and spread @drzul_albakri @imamalaysia @FIMAweb 8/10

3. Better still, if the #CovidVaccines act like the conjugated vaccines (MCV and PCV)), by conferring mucosal immunity, they sterilize the upper airway and prevents its emission into the air space and therby reduce the spread of the coronavirus 9/10

These I anticipate are the secondary objectives of their mRNA vaccine studies.
Hence, there is no data presently to address this issue of #COVID19 transmission by the vaccinees 10/10

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