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Michael Mina Profile picture
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9 Dec, 4 tweets, 2 min read
One of my favorite scientific themes is the identification of within-host immune kinetics from population data.

The divergence of the curves following pfizer #COVID19 vaccine at around day 10 demonstrates perfectly the time required for antibody secreting cells to proliferate
the data for this graph - and the graph itself is from fda.gov/media/144245/d…
Here, we identified the immunological consequences of measles infections on immunity based on population level data.

science.sciencemag.org/content/348/62…
Which we subsequently confirmed by looking at the blood of measles infected individuals here:

science.sciencemag.org/content/366/64…

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More from @michaelmina_lab

Michael Mina Profile picture
14 Dec
It PAINS & infuriates me that we continue a path of INACTION beyond a vaccine

Deaths are increasing. Yet our leaders CHOOSE to do nothing

The nation should be in an uproar!

We could ALL know our infection status daily & stop #COVID19

Instead our leaders choose dying
Pathetic.
Vaccines are great - But not getting to everyone now - and not for many months.

We have a tool now that could allow society to run MUCH safer.

Holidays spent MUCH safer
Stores and restaurants open and MUCH safer
Schools MUCH safer

This is doable, now-if our leaders wanted it.
Today, we have US companies making millions of rapid tests that people COULD be using to:

Know if their child is bringing SARS-CoV-2 virus back from school
Safely go to work, dine at restaurant, shop for groceries.

Instead US companies are forced to ship them overseas.
Read 5 tweets
Michael Mina Profile picture
12 Dec
There aren't many bipartisan items in Congress these days

But there is one thing
• Frequent • Accessible • Rapid • At-Home Testing

To help curb the spread of #COVID19

On Wednesday I spoke first to the @Heritage Foundation and immediately after to the @NewDemCoalition

1/
Here is a link for the first talk, with the @Heritage Foundation - I believe there is a video recording of the event there, with @paulmromer and Doug Badger, moderated by Marie Fishpaw

2/
heritage.org/public-health/…
The second was to the @NewDemCoalition...

3/
Read 4 tweets
Michael Mina Profile picture
2 Dec
Have a #COVID19 test results that took more than a few days after the swab was taken??

Throw it out and refuse to pay!

A lab result delayed more than a couple days isn’t just not useful, it’s misleading and dangerous!

A test with a 4+ day turnaround should have EUA revoked.
The only way it’s useful is if it’s positive. Remember, start the isolation clock from the time of the swab. Not the result.
Also, I’m not blaming the labs here. Im highlighting a massive systemic problem.

Though I will say that all clinical labs have a responsibility to accept only specimens that they can process within a clinically relevant time. A 7-day turnaround does more harm than good.
Read 5 tweets
Michael Mina Profile picture
1 Dec
Getting tested during a pandemic is mostly to keep others around us safe. If +ve, the test wont change that

• Tests for #COVID19 should NOT require MD order
• No person should have to pay for a test intended to help them not infect others

This is Public Health, not medicine
Testing is also performed for medicine, of course.

And if you end up in the doctors office b/c you're sick-all bets are off w regard to pay (I'm not wading into chargemaster wars!)

But if getting a test simply b/c you don't want to infect others... you should NOT have to pay.
Also- lets be honest - the questionnaire to get a test to get an automatic doctors prescription from some doctor you don't know and will never talk to... it's complete BS.

It hikes up prices, plays into a medical versus a concerted public health response and offers little else
Read 4 tweets
Michael Mina Profile picture
30 Nov
Interesting to listen to how we were thinking in April vs today

This interview w @bbcworldservice on April 21 asks question "How likely are children to spread #COVID19"

We didn't have data- but models showed (correctly) kids are important in spread

bbc.co.uk/sounds/play/p0…
I think going back and seeing what we got right and what we got wrong, in hindsight, will be an important exercise to help us understand, with some objectivity, what tools/models will be most useful in future pandemics and what are total rubbish.
Speaking of Kids and infections.
Read 4 tweets
Michael Mina Profile picture
28 Nov
New efforts w mass testing in Liverpool have dropped incidence by 2/3rds in weeks

Not a “clean” pilot study of rapid tests bc other interventions also started at same time.

There are a few items that I’m not so aligned with that they are doing...

1/ washingtonpost.com/world/europe/l…
First I think it’s great that they are using rapid tests for asymptomatic screening! This absolutely needs to happen - particularly as evidence builds that transmission peaks before symptom onset.

So that is great!

2/
Also, for those in the US - know that UK is purchasing their rapid tests from a California based company!! Shipping 1 million tests to the UK for mass rapid test screening.

Wouldn’t it be nice if Americans could also reap the benefits of this American innovation... :/

3/
Read 9 tweets

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