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More from @HanCardiomd

13 Dec
📝 Major Clinical Trials for the Management of Stable CHD in the Past 2 Decades

📌COURAGE (2007)
📌BARI-2D ( 2009)
📌STICH (2011)
📌FAME-2 (2012)
📌FREEDOM (2012)
📌ORBITA (2018)
📌ISCHEMIA (2020)
@mmamas1973 @mirvatalasnag @ErinMichos @DavidLBrownMD @DLBHATTMD @iamritu
*COURAGE* (n = 2,287)
PCI + OMT vs. OMT in stable CHD
• All had evidence of ischemia
• 31% triple-vessel CHD
• 4.6 years median follow-up
• HR death/MI 1.05 (95% CI: 0.87 to 1.27
Read 10 tweets
12 Dec
Multimodality imaging in takotsubo syndrome: a joint consensus document of the European Association of Cardiovascular Imaging (EACVI) and the Japanese Society of Echocardiography (JSE) #EACVIBestof2020
Full paper is here 👇🏻
academic.oup.com/ehjcimaging/ar…
#EACVIMMIesc
CMR can visualize the entire spectrum of functional and structural changes that occur in patients with TTS.
In the acute phase, CMR is recommended in doubtful TTS cases, especially if diagnosis of another type of MINOCA (e.g. myocarditis) requires a different therapeutic approach
Although the role of nuclear imaging in TTS has not yet been well established in clinical practice, myocardial perfusion and sympathetic nerve innervation can be assessed by SPECT and MIBG. #EACVIBestof2020 #EACVIMMI #WhyCMR
Read 4 tweets
9 Dec
This fantastic review on SGLT2-inhibitors; discusses some of the cutting-edge hypotheses & concepts currently being explored around this drug class in an attempt better understand the molecular mechanics of this novel agent link.springer.com/article/10.100… @ShelleyZieroth @AndrewJSauer
SGLT2-inhibitors; more than just glycosuria and diuresis

Early mechanistic work around conventional Tx targets seem to be inconclusive. There are some emerging theories around its effect on myocardial energetics and calcium balance as well as on renal physiology @mvaduganathan
Unlike conventional sodium-driven diuretics, SGLT2i-mediated free water excretion is expected to be more efficient in relieving signs & symptoms of interstitial congestion without adversely compromising intravascular fluid status or causing reflex sympathetic activation @noshreza
Read 9 tweets

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