I'm watching the FDA's Vaccines and Related Biological Products Advisory Committee discuss Moderna's data. The vaccine is clearly effective at preventing severe disease and may also limit transmission. As with all #COVID vaccine candidates, long-term side effects are unknown. 1/
Here's a topic of debate: As the pandemic expands, vaccine recipients may be continually exposed to coronavirus. How will the vaccinated immune system respond? Here's why this matters: We've seen that side effects are more pronounced after Moderna's second inoculation. 2/
This is, in part, because the immune system is now primed to respond to the second dose. How will the primed human immune system react to repeated viral exposure? And what will Moderna do to monitor this? 3/
Will a subset of vaccine recipients have more pronounced symptoms after repeated exposure? (This seems unlikely, but remains unknown).
It's incredibly reassuring to see these nuances debated in an open forum and to see the study sponsor so prepared to track this phenomenon.
It's incredibly reassuring to see these nuances debated in an open forum and to see the study sponsor so prepared to track this phenomenon.
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