Many valuable viewpoints and papers published in @AnnalsofIM today and yesterday. First, modeling from @ADPaltiel, @jasonlschwartz and Amy Zheng makes the case for a single-dose regimen assuming a 75% efficacy to avert the same number of infections as 2.
acpjournals.org/doi/10.7326/m2…
Next, Barnabas and Wald argue for the consideration of a single-dose regimen in order to:
- Accelerate pandemic control
- Distribute the scarce commodity
- Mitigate adverse events

This is despite evidence of data from clinical trials.
acpjournals.org/doi/10.7326/M2…
Finally, @AshTuite, @SalomonJA and colleagues suggests a more dynamic strategy of reserving second doses: holding 10% of the supply for second doses during the first 3 weeks, 90% during each of the next 3 weeks, and 50% thereafter.
acpjournals.org/doi/10.7326/m2…
Finally, Thomas J. Bollyky argues that the challenges go beyond supply, saying that the U.S. has struggled to vaccinate large portions of the population in the past.

Highly recommend checking out each piece of this robust discussion.
acpjournals.org/doi/10.7326/M2…

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More from @bhrenton

5 Jan
Vaccines don't save lives, vaccinations do. The Trump administration's plan to get vaccines in to the arms of Americans has largely failed, with now only 28.4% of the distributed doses administered. Here I propose my vaccination plan, leveraging key locations for vaccination. Image
First, my initial tweet from over the weekend drawing attention to the issue:
Let's first identify the problem. Operation Warp Speed has excelled at producing a vaccine and accelerating its development, but it's the "last mile" problem that has failed. Underfunded health departments and lack of a federal plan has inhibited rapid vaccinations. Image
Read 34 tweets
4 Jan
Last week, the American College Health Association (@ACHA_Tweets) published new recommendations for colleges to reopen in the spring. @ColleenFlahert1's reporting is here — let's take a look at the highlights.
insidehighered.com/news/2021/01/0…
In lessons learned from the fall, ACHA emphasizes "Multilayered mitigation strategies with universal masking, physical distancing … accompanied by a coordinated public health strategy of robust testing, and contact tracing."
acha.org/documents/reso…
On mental health: "Now more than ever the need to
provide a menu of mental health and wellness services is
vitally important.…Students often want “just in time”
services that are timely, convenient, and accessible. "
Read 9 tweets
3 Jan
Relying on CVS and Walgreens as cornerstones of a vaccine rollout plan is like using a spigot at a camping site to put out a forest fire. We need to be erecting mass vaccination sites, strategically placed across the country. In the coming days I'll suggest some possibilities.
A key part of geography is studying the impacts of why places are located where they are. When we discuss vaccine rollout, we need to commit to equity and accessibility — not just rural and urban, but racial and economic equity as well. We need large sites and small sites.
I'm also not suggesting that one option/place/solution will work for the entire country. However, we must use spatial analysis to figure out what combination of locations would result in the greatest impact (in this case, servicing the greatest number of people).
Read 4 tweets
30 Dec 20
Most vaccine trackers by media outlets have been focusing on one metric: what percentage of the population has been vaccinated. However, the single-most important metric for us to currently watch is what percentage of doses distributed have been administered. Thread:
In the coming weeks and months, these numbers will prove to be important — Americans will want to see what percentage of their community has been vaccinated (ideally, fully vaccinated with two doses). However, we have been not focusing our attention on our last-mile issue.
It has only been within the previous few days that the public has turned its attention to the discrepancies between distribution and administration. This great piece by @NicholasFlorko and @OliviaGoldhill clearly shows the frustration from experts.
statnews.com/2020/12/29/pub…
Read 17 tweets
28 Dec 20
Tonight's #VaccinateAmerica dashboard update: 28 jurisdictions have vaccine dashboards with a total of 966,990 doses administered. This is an increase of 122,013 from yesterday. Keep in mind that states do back-report, especially with doses over Christmas.
public.tableau.com/views/COVID-19… Image
New view on the dashboard: Roll over each state on the top 2 maps to see curves new doses administered and distributed by date. For example, here are graphs for South Dakota and Florida (this view is best for states that report daily/frequently).
public.tableau.com/views/COVID-19… ImageImage
The CDC also updated its national counts, which you can see on the "CDC Data" tab. According to the CDC, over 2.1 million doses have been administered nationwide. Image
Read 4 tweets
28 Dec 20
Morning of December 28, 2019: 1 year ago today, I arrived in China with a group of students on a study abroad program, which would be suspended a month later due to the coronavirus outbreak. In this thread I'll do my best to chronicle the developments as I saw them, 1 year on. ImageImageImageImage
The first few weeks of the program were filled with normal classes and excursions around Beijing. It was really only until the third full week when we began becoming aware of what would turn out to be a pandemic. More updates to this thread to come around January 21, 2021.
If you can't wait until then, you can read the daily updates I posted here. Updates will be posted in local time — 13 hours ahead of ET.
offthesilkroad.com/2020/01/27/wuh…
Read 6 tweets

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