Tobias Hohl Profile picture
10 Jan, 10 tweets, 3 min read
1/n I read this article with tremendous interest and have some comments on this situation. Why are we in this situation? Conflicting forces are driving the vaccination process. At Elite Medical Centers, Even Workers Who Don’t Qualify Are Vaccinated nytimes.com/2021/01/10/hea…
2/n @sloan_kettering there was a deliberative and transparent process to identify and prioritize vaccination among patient-facing healthcare workers. However, hospitals in NY State were not yet allowed to offer vaccine to high-risk patients. Vaccine uptake is not uniform
3/n among priority patient-facing vaccine groups and since substantial financial repercussions were threatened if the vaccine was not administered very rapidly, this created an incentive to administer vaccine to other (lower risk) workers at academic medical centers. Remember
4/n that hospitals were not allowed to expand vaccination to patients. This is clearly a process issue and reflects poor planning at the state and federal level. If guidelines are overly restrictive (with regard to vaccine recipients), then rollout is frustratingly slow.
5/n If guidelines are more permissive, the rollout is more rapid and less targeted. I am very pleased that NYers >75 years old will soon have access to vaccine and that teachers and other public servants are included in this vaccination phase. I cannot emphasize enough that
6/n we need public, accessible, and low barrier to entry vaccine sites across our city, state, and nation, particularly concentrated in communities that have been hit the hardest by #SARSCoV2 - we need to open vaccine access and cannot do so without better federal and state
7/7 planning, cooperation, and execution. I am certain that my colleagues and I will volunteer at vaccine distribution sites and engage in vaccine education efforts to improve uptake - after all, we want to get the vaccine into as many arms as possible, as quickly as possible.
In other this words today’s article is the logical consequence of this order and restrictions placed on hospitals nytimes.com/live/2021/01/0…
The telling quote is “I don’t want the vaccine in a refrigerator. I want it in someone’s arm...So yes, I am being aggressive” @NYGovCuomo while threatening 100K fines. It’s easy to be selective, targeted, and slow. Easy to be fast and not selective. Very hard to be selective,
targeted and fast, particularly without an effective city- and statewide plan in action that covers the freezer to arm step and delegates this only to a few medical centers. This will now change, but where we are reflects a leadership failure at the executive level.

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More from @tmhohl71

10 Jan
If @NYGovCuomo had widened eligibility first, as in: nytimes.com/2021/01/08/nyr…
Note that this happened on January 8th, 2021.

(1/n)
then NY Hospitals would have acted differently to his prior order of "Use it or Lose it, and Get Fined", issued on January 4, 2021. At this time, hospitals were NOT allowed to vaccinate patients, even though many were clamoring to do so. (2/n)

nytimes.com/video/us/polit…
As a consequence, it is not surprising (and entirely predictable based on the incentive created by @NYGovCuomo) that many academic medical centers vaccinated lower-risk and non-patient facing staff, as outlined today in the @nytimes by @apoorva_nyc (3/n) nytimes.com/video/us/polit…
Read 9 tweets
3 Jan
Concerned about the #COVID19 vaccines and autoimmune disease?

Both the #Moderna and #Pfizer vaccines do not contain an attenuated virus or instructions (via mRNA) to make viral particles that could replicate in vaccine recipients. (1/n)
I have psoriatic arthritis (on #methotrexate for about a decade) and had no hesitation to receive the vaccine @sloan_kettering. I am fortunate and was able to stop methotrexate for one month prior - this is atypical for most patients with autoimmune diseases - and will (2/n)
resume the medication a month after the second shot. I stress that this is not a medical recommendation for other patients with psoriatic arthritis or any other autoimmune disease. Patients should discuss how treatments for autoimmune conditions may impact vaccine immunity (3/n)
Read 9 tweets
5 Apr 20
1/n Much will be made about this case report. I am very pleased that the patient did well and survived #COVID19 after a difficult course. On the heels of tweeting about anti IL-6 therapy (tocilizumab) I'm taking a stab at this case report. ashpublications.org/bloodadvances/…
2/n It is a purely correlative, observational study. The title is misleading though. An alternate, equally valid title would be: First case of COVID-19 in a patient with multiple myeloma successfully treated with methylprednisolone. The patient received corticosteroid (MP)
3/n therapy on five consecutive days (day +2 to day +6). On day +9 the patient received tocilizumab. He continued to improve and was released from the hospital 10 days later. Did tocilizumab cause this improvement? It is impossible to tell. However, I conclude that it is safe to
Read 8 tweets
5 Apr 20
1/n I am thinking about the various modes of #COVID19 transmission. Although not common, gastrointestinal symptoms are routinely reported by COVID patients. In humans, the SARS-CoV2 receptor ACE2 is not only found in alveolar epithelial cells (lung), but also in cells that line
2/n the small intestine, among other sites (heart and kidneys). Humans shed high levels of #COVID19 in the stool, a finding that raised the question whether fecal-oral transmission may occur. This would be very relevant for measures to limit the spread of disease.
3/n The concern for fecal-oral transmission is clearly outlined in this review. nature.com/articles/s4157…
Read 11 tweets
2 Apr 20
1/n I am asked on a daily basis about IL-6 blockade in #COVID19 patients @sloan_kettering . The truth is that I don't know if this intervention is helpful, neutral, or harmful. Colleagues point to the role of IL-6 blockade in treating CAR T cell toxicities and its cytokine storm.
2/n In the CAR T cell setting, IL-6 is clearly pathological and the IL-6 levels observed are typically far higher (10x or more) than those in critically ill COVID19 patients. It is not at clear to me that this concept is applicable to COVID. Why? There are important differences
3/n between a viral infection and genetically engineered T cells that causes a sterile inflammation. First, your immune system needs IL-6 to stimulate T follicular helper cells to foster Ab responses. This is likely to be important in generating sterilizing humoral (Ab-mediated)
Read 6 tweets
2 Apr 20
1/n One of the most challenging things about the #COVID19 outbreak in NYC is having to act both fast and slow. What do I mean by this? On one hand, as an ID physician, I am in state of perpetual impatience. I want to do the best possible thing for the one patient under my care at
2/n any particular moment. I want the instant gratification of feeling I did something important and relevant for this particular human being. So my heart wants to tear open a package of hydroxychloroquine and offer a tablet, to set up the IV for an infusion of convalescent
3/n serum, to block cytokines that are elevated in a patient's serum, to provide medications to ease a cough. That's the fast. On the other hand, my mind knows that hydroxychloroquine has not shown antiviral activity against any human viral disease in the clinic (the jury is out
Read 13 tweets

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