L-glutamine (a GABA precursor) was studied clinically for COVID-19, but the study was poorly designed and results were rather weak. I expect little benefit from glutamine in COVID-19.
How could you possibly justify refusing to treat *known, universally* elevated plasma 5-HT, in an often-lethal disease state that is *defined* in part by *frank, known symptoms of elevated plasma 5-HT*?
The things we are discussing about 5-HT2 antagonists and plasma serotonin, about attempting to halt progression in the early severe stage, are relevant *during* these events.
Rates of PTSD following survival from severe COVID-19 exceed 30%, ditto anxiety and depression.
The ventilator settings required to keep these patients alive tend to permit blood CO2 levels to rise somewhat, in avoiding excessive mechanical damage to the lungs.
This has been repeatedly demonstrated to cause severe anxiety and promote PTSD.