1/ If there's some joint pain
In your neighborhood
Who you gonna call? 📞
🤯GOUT BUSTERS 👩⚕️
PGY-1 @Jen_LS_Hanberg gave a talk on
💊Urate-Lowering Therapy (ULT)💊
Let's review some pearls!
@MeganLockwoodMD @MGH_MSUS #MedTwitter #RheumTwitter #Nephtwitter #Gout
In your neighborhood
Who you gonna call? 📞
🤯GOUT BUSTERS 👩⚕️
PGY-1 @Jen_LS_Hanberg gave a talk on
💊Urate-Lowering Therapy (ULT)💊
Let's review some pearls!
@MeganLockwoodMD @MGH_MSUS #MedTwitter #RheumTwitter #Nephtwitter #Gout
2/ Who gets ULT?
The strongest indication is for patients with:
✅2 or more flares annually
✅Radiographic damage due to gout
✅TOPHI
The strongest indication is for patients with:
✅2 or more flares annually
✅Radiographic damage due to gout
✅TOPHI
3/ What are your ULT options? Check out the awesome slide below.
Takeaways:
💊Start with allopurinol! It will give you the biggest bang for your buck
💊Your target UA level is 6⃣- titrate q2-4 weeks
💊Start prophylactic therapy at the same time (NSAID, colchicine, pred)
Takeaways:
💊Start with allopurinol! It will give you the biggest bang for your buck
💊Your target UA level is 6⃣- titrate q2-4 weeks
💊Start prophylactic therapy at the same time (NSAID, colchicine, pred)
4/Quick pause for a question to jog a memory from your USMLE step 1 days.
What antihypertensive medication has a uricosuric effect?
What antihypertensive medication has a uricosuric effect?
5/ ANS: Losartan!
Key things to check *before* starting allopurinol:
🧪GFR
🧪HLA–B*58:01 in individuals of Southeast-Asian descent & and African-American individuals!
This allele is strongly associated with severe cutaneous adverse reactions (SCAR) w allopurinol like SJS!
Key things to check *before* starting allopurinol:
🧪GFR
🧪HLA–B*58:01 in individuals of Southeast-Asian descent & and African-American individuals!
This allele is strongly associated with severe cutaneous adverse reactions (SCAR) w allopurinol like SJS!
6/ Here is a summary slide with take-home points!
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