1/
In non-COVID-19 pneumonia/ARDS filling defects are found in pulmonary arteries branches vascularizing healthy lung segments. Instead, in #COVID19 there is an almost perfect topographical overlap of filling defects distribution & pneumonia extent.
🔗 jcvaonline.com/article/S1053-…
In non-COVID-19 pneumonia/ARDS filling defects are found in pulmonary arteries branches vascularizing healthy lung segments. Instead, in #COVID19 there is an almost perfect topographical overlap of filling defects distribution & pneumonia extent.
🔗 jcvaonline.com/article/S1053-…
2/
We demonstrated that pulmonary vascular thrombosis in #COVID19 is due to local inflammatory endothelial damage with a superimposed thrombotic late complication and not to recurrent thromboembolism from peripheral deep vein thrombosis.
#MicroCLOTS
We demonstrated that pulmonary vascular thrombosis in #COVID19 is due to local inflammatory endothelial damage with a superimposed thrombotic late complication and not to recurrent thromboembolism from peripheral deep vein thrombosis.
#MicroCLOTS
3/
51% of pts showed pulmonary vascular thrombosis, with a median time from symptoms of 18 days.
We identified a specific radiological pattern of #COVID19 pneumonia with a unique spatial distribution of pulmonary vascular thrombosis overlapping areas of ground-glass opacities.
51% of pts showed pulmonary vascular thrombosis, with a median time from symptoms of 18 days.
We identified a specific radiological pattern of #COVID19 pneumonia with a unique spatial distribution of pulmonary vascular thrombosis overlapping areas of ground-glass opacities.
4/
Simultaneous multiple thromboses were identified in 79%, with bilateral involvement in 57%.
Remarkably, in all 28 patients, ground-glass opacities areas and pulmonary vascular thrombosis had an almost perfect spatial overlap.
#MicroCLOTS
Simultaneous multiple thromboses were identified in 79%, with bilateral involvement in 57%.
Remarkably, in all 28 patients, ground-glass opacities areas and pulmonary vascular thrombosis had an almost perfect spatial overlap.
#MicroCLOTS
5/
Filling defects were typically found in segmental (19/28, 67.8%) and subsegmental branches (27/28 96.4%).
#MicroCLOTS
Filling defects were typically found in segmental (19/28, 67.8%) and subsegmental branches (27/28 96.4%).
#MicroCLOTS
6/
Our group previously hypothesized that this host immune response may cause massive vascular endothelial and alveolar epithelial cell damage with microvascular thrombosis worsening V/Q imbalances and loss of hypoxic vasoconstrictors reflexes.
Our group previously hypothesized that this host immune response may cause massive vascular endothelial and alveolar epithelial cell damage with microvascular thrombosis worsening V/Q imbalances and loss of hypoxic vasoconstrictors reflexes.
https://twitter.com/SRAnesthesiaICU/status/1250797241737994242?s=20
• • •
Missing some Tweet in this thread? You can try to
force a refresh
