1/ Colchicine may be an effective treatment for #COVID19.

In a well designed trial (prospective, randomized, >4000 people) colchicine "resulted in a 25% decrease in hospitalizations, a 50% decrease in the use of ventilation & a decrease in deaths by 44%.“ bit.ly/39Vwpls
2/ This was in non-hospitalized patients with confirmed infection.

Standard caveats: Press release, no preprint data, etc.

Colchicine is a cheap, widely available pill.

If this pans out it will be very helpful - works via anti-inflammatory (& immunomodulatory?) mechanism.
Also, I'm still baffled that a pre-print (with actual data/analyses) could not be made available at the time of press release. That should be standard.
This is the study protocol:

Important items to the above thread:

1. Would not get excited until we see the data.

2. Colchicine has a narrow therapeutic range and potential toxicity.

3. Would never take this medication unless under close medical supervision.

4. It also causes wicked diarrhea.

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More from @BogochIsaac

25 Jan
"Vaccination with the Moderna #COVID19 Vaccine produced neutralizing titers against all key emerging variants tested, including B.1.1.7 and B.1.351, first identified in the UK and Republic of South Africa, respectively."

**Translation: This is really good news.**
(Also, yes this is science by press release, but see how they included valuable information/data here?)
There may still is an attenuated response to the variant discovered in South Africa, but it appears the vaccine will still provide some protection - and there is a lot more to an immune response than these antibodies.
Read 6 tweets
17 Nov 20

So #COVIDzero is trending.

What's not to like about zero cases of #COVID19?

1. How can we get there?
2. Is this feasible in Canada?

Some unpopular opinions & perhaps a few hard truths below...
2/ With a #COVIDzero strategy or not, it is clear that we should improve/continue to:

1. Evaluate & address drivers of #COVID19 in the community

2. Bolster a Test-Trace-Isolate-Support system

3. Support communities & businesses disproportionately impacted by the virus

3/ What would it actually take to *operationalize* #COVIDzero in Canada? How do we get to (or near) zero cases & maintain it?

***It would take prolonged & full lockdown (3-5 months based on current burden?) where #COVID19 is crushed, then ongoing supports to suppress this***
Read 15 tweets
16 Nov 20
Wow - More positive #COVID19 vaccine news.

Moderna's interim analysis shows ~95% efficacy in their Phase 3 trial!

Yes, lots of unanswered questions & more science by press release, but very positive news none the less.

Other very helpful points:

"Of 11 participants who developed severe Covid while on the trial, all were in the placebo group."

"The results also suggest the vaccine is effective in older people and those from diverse ethnic backgrounds."

From a logistical standpoint - MUCH easier to transport.

"the vaccine can be kept in a conventional freezer at -20C for up to 6 months and that once thawed the vaccine can be kept for up to 30 days at standard refrigerator temperatures of 2 to 8C."
Read 6 tweets
13 Nov 20
Very reasonable adjustments to the #COVID19 response in Ontario.

-Limit trips
-Work remotely
-Stay within your household

Significant adjustments to the colour-coded framework:

*Red Zone thresholds lowered* from 10% positivity to 2.5%; 100 new cases/100k to 40/100k. Image
It took a while, it took some pushing (translation: it took a lot of pushing), but the province moved on this. Phew. Good move.
Here is the updated framework.

ontario.ca/page/covid-19-… Image
Read 5 tweets
9 Nov 20
"A vaccine against #COVID19 is in sight, with the announcement of the first interim results in large-scale trials showing the Pfizer/BioNTech candidate is 90% effective"

Pro: Amazing- if this holds true.
Con: Science by press release, let's see the data.

ps: Canada has access to this one.

pps: While clearly very promising and exciting, best to see the final data on safety and efficacy.

ppps: "People from black and minority ethnic backgrounds appear to have been as well protected as everyone else, the company says."
Additional helpful details:

-Trial is enrolling 43000 people
-They've had 94 cases of #COVID19
-Much more covid in non-vaccinated group...less than 10% of those vaccinated diagnosed with covid
-Protection seen 7 days after 2nd dose of vaccine
-Goal is to enroll up to 164 cases
Read 6 tweets
11 Oct 20
Fomite transmission (from inanimate objects) of SARS-CoV-2 is much less of an issue than previously thought.

Some recent data:

Hand hygiene is still important & I hope better hand hygiene is a lasting legacy of this pandemic.
Policy is keeping up with emerging data...

For example the CDC acknowledges that one can get infected from touching contaminated surfaces, but adds...

"Spread from touching surfaces is not thought to be the main way the virus spreads."

Also, in a recent Lancet letter:

"Our findings suggest that environmental contamination leading to SARS-CoV-2 transmission is unlikely to occur in real-life conditions, provided that standard cleaning procedures and precautions are enforced."

Read 4 tweets

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