Merck’s vaccines are out of the running. These two used yet a different mechanism to try to protect against the virus. In this case, it didn’t work.
What the Merck vaccines tried to do was combine the asshole protein on to a weakened live virus (not the COVID virus, in both vaccines it was a different virus). So basically this guy, but with the asshole protein spliced in.
That’s different than the AstraZenica vaccine, which gives you the asshole protein instructions in an empty shell of a virus that doesn’t replicate in your body.

The Merck ones put it in a weak virus that CAN replicate in your body.
The argument for this is that if the weak virus can replicate, it will pump out asshole proteins for a longer time, giving your body more practice shooting them down and giving it better long-term memory.
However, in studies, the measured immune response was not as strong as a normal COVID infection or as strong as the other vaccines.

So it’s a no-go.
By the way, when people say vaccines usually take years to develop, this is ‘one’ reason why. You try something, it doesn’t work, so then you try something else.

With COVID, we’ve got 100+ different vaccine candidates, using different methods, all being tested concurrently.
Some vaccines will work. Some won’t. We don’t have to wait for one or two to fail before trying the next. Every pharmaceutical company is shooting their shot and we pick the ones that work. That’s never happened before & may never happen again. That’s ‘one’ reason it’s been fast.

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with WheatNOil

WheatNOil Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @WheatNOil

25 Jan
Hockey thread time:

7 games into the season and the Oilers are running one all-world line and are otherwise running in sand.

Among forwards with at least 5 games, only McDavid, Nuge, and Puljujarvi are running over 50% in score-adjusted shot attempts at 5x5.
Even Drai and Yamomoto are running at 45% shot attempts, though they’re hovering around 50% in expected goals, so at least it’s not ‘all’ luck.

The bottom 6 is... well... Turris is running 34%. Oilers are getting outshot 2 to 1 with him on the ice! It’s a mess!
But there’s something else here too.

The defense:
Bear and Nurse are clear above 50%. They’re expected goals are almost 66%! Amazing!

After that, everyone else is 43% or below. Larsson is at 38%! The expected goals are the same.

We have one pair and mud.
Read 8 tweets
4 Jan
China recently approved the Sinovac vaccine and since apparently this is what I do in my spare time now, let’s talk about how that one works!

It works in yet a different way than the mRNA (Pfizer / Moderna) or the AstraZenica vaccines.
The Sinovac vaccine is a more traditional vaccine type. It’s an “inactivated” vaccine. That’s different from another traditional vaccine type: an “attenuated” vaccine.

I should take a moment to clarify the difference.
Think of an “attenuated” vaccine (also sometimes called a “live” vaccine) is when you take a virus and make it way less dangerous. It’s basically your body fighting against this guy.
Read 11 tweets
3 Jan
So, people have taken the time to translate my explanation of mRNA vaccines into a bunch of different languages. I’ll post them in this thread in case you have a non-English friend, relative, potty-mouthed grandma who’d like to know how this vaccine works.
German
(I don’t know German but I love this translation because you just ‘feel’ the swears in German.)
Read 11 tweets
31 Dec 20
Some have asked me about how the AstraZenica vaccine is different than the mRNA vaccines. @ScientistSwanda does a great job here describing it. The vaccine is still all about the asshole protein, your body just produces it in a different way.
I guess to describe it in the theme of my other threads:

Scientists took a totally different virus that doesn’t hurt humans. They cut out most of the virus DNA until what was left was a mostly empty shell. (The virus is now basically us by the end of this godforsaken year.)
So you take this basically empty shell of a virus and you throw in the code to make the infamous asshole protein. So now you’ve got a toothless virus that can’t do shit to you except make asshole proteins.
Read 12 tweets
26 Dec 20
I’ve had a few questions to this end and it’s a good one.

The first thing to know is that “the flu” isn’t just one thing.

COVID-19 is a specific asshole. Like Steve your next door neighbour.

“Influenza” is a larger category of jerks.
COVID-Steve has a particular weak spot. Without that protein, he’s not nearly as effective. That’s fortunate. It makes him easier to target. Steve also tends to be slower to change (or mutate).

Not every virus has a weak spot like that.
Influenza is a whole category of jerks with lots of different strains. They mutate quickly. They mix and match. They have different proteins on the outside. (That’s part of what the names of them mean: H1N1 refers to the names of the proteins on the virus, as an example).
Read 6 tweets
26 Dec 20
Via @IneffectiveMath, Slater Koekkoek played 3rd pairing minutes for Chicago last year (as he’s mostly done for his career). Last year the team did well in shots and goals with him on the ice. He started a lot in the D-zone & took a lot of penalties.
Via @puckiq, he wasn’t particularly sheltered against elite competition. More middle of the road. In Tampa he played against less elite competition in a more traditional 3rd pair role.
I think it’s fair to say Edmonton signed a pretty solid 3rd pairing defender. He ‘might’ do okay on the 2nd pair but we don’t have a great sample size with him there.
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!