What the Merck vaccines tried to do was combine the asshole protein on to a weakened live virus (not the COVID virus, in both vaccines it was a different virus). So basically this guy, but with the asshole protein spliced in.
That’s different than the AstraZenica vaccine, which gives you the asshole protein instructions in an empty shell of a virus that doesn’t replicate in your body.
The Merck ones put it in a weak virus that CAN replicate in your body.
The argument for this is that if the weak virus can replicate, it will pump out asshole proteins for a longer time, giving your body more practice shooting them down and giving it better long-term memory.
However, in studies, the measured immune response was not as strong as a normal COVID infection or as strong as the other vaccines.
So it’s a no-go.
By the way, when people say vaccines usually take years to develop, this is ‘one’ reason why. You try something, it doesn’t work, so then you try something else.
With COVID, we’ve got 100+ different vaccine candidates, using different methods, all being tested concurrently.
Some vaccines will work. Some won’t. We don’t have to wait for one or two to fail before trying the next. Every pharmaceutical company is shooting their shot and we pick the ones that work. That’s never happened before & may never happen again. That’s ‘one’ reason it’s been fast.
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China recently approved the Sinovac vaccine and since apparently this is what I do in my spare time now, let’s talk about how that one works!
It works in yet a different way than the mRNA (Pfizer / Moderna) or the AstraZenica vaccines.
The Sinovac vaccine is a more traditional vaccine type. It’s an “inactivated” vaccine. That’s different from another traditional vaccine type: an “attenuated” vaccine.
I should take a moment to clarify the difference.
Think of an “attenuated” vaccine (also sometimes called a “live” vaccine) is when you take a virus and make it way less dangerous. It’s basically your body fighting against this guy.
So, people have taken the time to translate my explanation of mRNA vaccines into a bunch of different languages. I’ll post them in this thread in case you have a non-English friend, relative, potty-mouthed grandma who’d like to know how this vaccine works.
Some have asked me about how the AstraZenica vaccine is different than the mRNA vaccines. @ScientistSwanda does a great job here describing it. The vaccine is still all about the asshole protein, your body just produces it in a different way.
I guess to describe it in the theme of my other threads:
Scientists took a totally different virus that doesn’t hurt humans. They cut out most of the virus DNA until what was left was a mostly empty shell. (The virus is now basically us by the end of this godforsaken year.)
So you take this basically empty shell of a virus and you throw in the code to make the infamous asshole protein. So now you’ve got a toothless virus that can’t do shit to you except make asshole proteins.
COVID-Steve has a particular weak spot. Without that protein, he’s not nearly as effective. That’s fortunate. It makes him easier to target. Steve also tends to be slower to change (or mutate).
Not every virus has a weak spot like that.
Influenza is a whole category of jerks with lots of different strains. They mutate quickly. They mix and match. They have different proteins on the outside. (That’s part of what the names of them mean: H1N1 refers to the names of the proteins on the virus, as an example).
Via @IneffectiveMath, Slater Koekkoek played 3rd pairing minutes for Chicago last year (as he’s mostly done for his career). Last year the team did well in shots and goals with him on the ice. He started a lot in the D-zone & took a lot of penalties.
Via @puckiq, he wasn’t particularly sheltered against elite competition. More middle of the road. In Tampa he played against less elite competition in a more traditional 3rd pair role.
I think it’s fair to say Edmonton signed a pretty solid 3rd pairing defender. He ‘might’ do okay on the 2nd pair but we don’t have a great sample size with him there.