This week we are going to cover some #Endocrinology topics for #medstudenttwitter.
Going to start with some fundamentals to get us going as grasping these basics really makes interpretation much easier!
Going to start with some fundamentals to get us going as grasping these basics really makes interpretation much easier!
Endocrinology is about communication! 📞📢
Hormones are messengers that travel around the body to act in distant organs and tissues.
There are 2 main types of hormones. Knowing a little about this helps predict hormone behaviour:
Hormones are messengers that travel around the body to act in distant organs and tissues.
There are 2 main types of hormones. Knowing a little about this helps predict hormone behaviour:
STEROIDS🔶 – cortisol, aldosterone, sex hormones. Vit d and thyroid hormones are included in this group as they behave similarly.
Water insoluble - circulate on binding proteins, have long t1/2
Diffuse across lipid membrane to act via NUCLEAR receptors ➡️ SLOW effect on genes
Water insoluble - circulate on binding proteins, have long t1/2
Diffuse across lipid membrane to act via NUCLEAR receptors ➡️ SLOW effect on genes
PEPTIDES 🔷– most hormones inc pit hormones (e.g. ACTH), insulin & other gut hormones, PTH…
Water soluble - circulate freely, often v short t1/2 (can be mins)
Can’t cross cell membrane ➡️ act on membrane receptors which trigger intracellular signalling e.g. via G proteins
Water soluble - circulate freely, often v short t1/2 (can be mins)
Can’t cross cell membrane ➡️ act on membrane receptors which trigger intracellular signalling e.g. via G proteins
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