1/ Just heard @CDCDirector on @CNN @drsanjaygupta push back on the proposal @AbraarKaran @sri_srikrishna & I put forward on the gov't sending N95-caliber masks to every home (cnn.com/videos/health/…)

A quick rebuttal

THREAD
2/ Dr. Walensky's counterpoints to this idea seem to be:

- N95-caliber masks aren't necessary; multi-layer cloth + 6 feet is good enough

- access to masks is not a bottleneck

- N95-caliber masks are hard to wear for long periods
3/ For the 1st point, we know that Covid can spread via aerosols indoors & in crowds

Cloth masks only variably block (~50-70%) & surgical masks up to 80%

People -especially essential workers, those at high-risk- need better protection particularly in poorly ventilated scenarios
4/ For 2nd point, @CDCDirector seemed to think @andersoncooper was asking about masks in general & not specifically high-caliber masks

Access to *high-caliber* masks is a challenge & people don't know which ones & where to get them & some may not be able to afford them
5/ For 3rd point, I agree that N95s are hard to breathe in for long periods

But most people though would only need to wear for shorter periods (eg, grocery store) & there are more comfortable options such as KF94s, elastomerics & others close to NIOSH approval (eg, @one_canopy)
6/ This is why a number of other countries are moving to also promote or mandate such masks for their populations

washingtonpost.com/world/europe/e…
7/ We need to do everything we can stop transmission to save lives now, prevent the emergence & spread of faster-spreading deadlier variants & time to get vaccination up to scale

If supply is the reason we're hesitating on doing this, then let's solve it (ie, invoke DPA)

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More from @RanuDhillon

17 Jan
We're deploying vaccines like we do annual flu shots rather than the mass vaccinations done in Africa & Asia where millions are vaccinated in weeks

Years ago, Joe Rhatigan & I studied these campaigns. They offer several lessons that can inform what we need in the US now

THREAD
1/ Be proactive

Instead of passively waiting for people to come get vaccinated, we need to search them out & go to where they are & keep following up until they opt out or are vaccinated

We should be rolling out the vaccine like we do the Census, even going door-to-door
2/ Remove barriers & be redundant

In each community, have multiple ways to get vaccinated including CVS/Walgreens, pop-up sites & near high-throughput places people have to to go like grocery stores

Make some venues 24/7 so people can get vaccinated anytime that works for them
Read 9 tweets
29 Nov 20
In 2014, I was on a 'task force' convened by Guinea's President to forge a nat'l Ebola response

Cases were spiking, it was a polarizing election year &, though many efforts were happening, there was no overall strategy or unified response

Here's how we set up the response

1/15
The first step was to establish a clear chain-of-command leadership structure under the National Ebola Coordination Cell with Dr Sakoba Keita as its head

All partners (eg, WHO, MSF, other ministries) & all response activities had to go through the Cell

2/15
We then created an overarching national strategy that included all interventions (eg, testing, contact tracing)

This wasn't just a laundry list of things that could help but aimed to spell out the combo of measures needed to actually reach zero within a defined timeframe

3/15
Read 17 tweets
5 Oct 20
(1/3) The 3 greatest health challenges of this century - pandemics, non-communicable diseases, health effects of climate change - will require

(1) health systems premised on primary care that integrate population health

(2) stronger mechanisms for global coordination & action
(2/3) #1 can be achieved by merging best practices that thus far happen in isolation into integrated systems that leverage technological- connectivity, AI, automation- tools to orchestrate/facilitate high-quality replicable execution at scale

(More soon @OptimizeHealth_)
(3/3) #2 is less of a technical & logistical challenge than a human, social & political one & therefore much more complicated to find a clear path towards achieving but achieve it we must
Read 4 tweets
5 Oct 20
(1/5) To put Trump being started on dexamethasone in perspective, we do it for patients when they become hypoxic

Some patients I've had are on remdesivir/dexa like Trump is now & only require a touch of oxygen (eg, 2L) for a day or two & then come off it.
(2/5) Even when on oxygen, they may look, feel, talk etc. like they're fine & you wouldn't know they were hypoxic unless you took off the oxygen & saw their O2 saturation
(3/5)Others on remdesivir/dexa end up as sick as anyone can be including on a ventilator, paralytics, etc & either pass away or recover after a prolonged & arduous course

Bottom line: there's huge variation which makes it tough to pinpoint where someone might be on that spectrum
Read 5 tweets
4 Oct 20
(1/4) Other than the experimental antibodies, Trump has gotten what - remdesivir, dexamethasone - we give to our Covid patients with hypoxia
(2/4) From the way questions were answered, the fact that dex was started (which can have side effects including confusion) & he was on supplemental O2 suggests to me that his O2 may have been lower than they are letting on

Supplemental O2 usually isn't given unless O2 sat <90%
(3/4) With Covid19 & pneumonias in general, you typically don't get 'transient' drops in O2 as much as persistent (& potentially progressive) hypoxia lasting for at least hours

Transient drops usually happen from mucous plugs or aspiration

Unclear to me what the actual story is
Read 4 tweets
14 Sep 20
1/ A hang-up on rapid tests that I've heard is that it'll be difficult for health depts to track results

Decentralized screening makes that difficult but stopping spread should be the overwhelming priority; monitoring indirectly helps stop spread but is a secondary consideration
2/ We shouldn't hold up something that can stop transmission because it will be harder to monitor or collect data on

The current counterfactual is that we're missing most infections anyway & neither stopping onward transmission from them or getting any data on them
3/ What's generally been missing from the rapid testing discussion are counterfactuals

Anyone can point out issues that arise if using them but that is meaningless without considering what is happening w/o them & thoughtfully strategizing on how to address potential downsides
Read 5 tweets

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