GOOD to see high efficacy (89% in the U.K. 15k arm) against the U.K. variant.

Less good that it suggests 50% efficacy v SA variant (smaller cohort with 4.4K volunteers) but that is still a lot better than none.
“The researchers also carried out a post-hoc analysis looking at efficacy for particular strains

they estimated an efficacy of 95.6% against the original COVID-19 strain and 85.6% against the UK variant strain B.1.1.7”

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More from @fascinatorfun

29 Jan
AstraZeneca was signed as Oxford’s partner on 30 April and signed a deal to supply 100m doses to the UK a fortnight later. Ministers were prepared to pay a few hundred million upfront, allowing the company to build its first virus manufacturing process.

theguardian.com/society/2021/j…
The deal was - from the UK government - a demand its citizens be vaccinated first.

“That underpinned all of it,” an industry insider said.

Two sites (Oxford and Keele) were set up to start “brewing” the vaccine. There were early issues but were overcome in 3 months Image
Bottling takes place in Wrexham....where the suspicious package was.

All credit to getting the manufacturing investment in place early enough to overcome inevitable early teething troubles and produce plenty of vaccine.
Read 6 tweets
29 Jan
I shall wait to summarise today’s data due to a hiccup on the Covid dashboard re death data.

🦠🦠🦠29,079 new cases

First time admissions have been under 3k since New Year’s Eve Image
VACCINATION 💉 looks as if an improvement after a slower couple of days

Total of 8,369,438 doses administered to 7,891,184 people.

478,254 of those people have had second doses.

That really is very good performance.

Gratitude to the Vaccination logistics and deployment teams Image
🏥 2903 admissions
🛌 35375 IN Patients
VENTILATOR 🛏 3918
3585 in England is a clear continual drop over a full week

Still pretty horrendous numbers but undoubtedly a slowing of ingress.

Lockdown IS working albeit we hoped it might just a bit faster. ImageImageImage
Read 7 tweets
29 Jan
Can you help @andrew_croxford

I think the paper concerned suggests the subject picked up Covid twice, once in May and once in October. Two different variants with the first incident producing insufficient immune response to prevent the second variant.
The relevant paper according to @pash22 is this one

I don’t think it suggests she carried two variants at once

preprints.org/manuscript/202…
Sorry.

The author of the Reuters article says this is the relevant paper

medrxiv.org/content/10.110… Image
Read 4 tweets
29 Jan
In the unlikely event you haven’t seen this @davidallengreen @syrpis

AZ contract with the EU

Not identical to CureVac.

I wonder why price redacted given AZ agreemen with Oxford Uni to sell at cost

ec.europa.eu/info/sites/inf… ImageImageImage
“AZ shall NOT be deemed in breach of this Agreement as a result of any such delay due to the aforementioned competing agreement(s)".

Seems to refer to “competing agreement entered into by or on behalf of the Commission” (ie not U.K - AZ contract). Image
U.K. manufacturing site specifically included in the contract, for the purposes of A5.4 only, as an EU site.
Read 5 tweets
28 Jan
The Facebook Oversight Board’s 1st Decisions:

There are 5 cases, each running a little over 10 pages, each telling FB what to do with a single piece of content
All but one are unanimous
4 overturn FB’s original decisions to remove posts
1 agrees with FB

lawfareblog.com/facebook-overs…
Extraordinary the number of decisions taken by Facebook moderators.

Do five decisions really have any impact? What about the more quotidian cases as opposed to the big Trump fanfare ones?
The 80% reversal rate is not the only sign that the FOB does not intend to extend Facebook much deference. These decisions show the FOB’s intention to interpret its remit expansively to attempt to force Facebook to clean up its content moderation act.
Read 4 tweets
28 Jan
Lovely LOVELY clear explanation here about shorting stock and how a subset of the public has been playing hedge funds at their own game.

Enjoy!
Read 4 tweets

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