Katri Typpo presenting the basic science arm of the Peds Year in Review (it's not all SARS-CoV2) #CCC50 #PedsICU
Typpo: looking at mechanism of Cytokine Release Syndrome in CAR-T therapy #CCC50 #PedsICU by Liu at al Blocking GSDME may prevent CRS 
Typpo: in situ recruitment of regulatory T-cells promotes donor specific tolerance in vascularlized composite allotransplantation - teaching T-cells to tolerate transplants, and help reduce rejection #CCC50 #PedsICU
Typpo: Gut educated IgA defends meningeal venous sinuses, role in gut microbiome in preventing meningitis particularly in critical illness #CCC50 #PedsICU
Typpo: SLC25A51 role in NAD+ transport and mitochodrial function, big implications in energy metabolism in critical illness #CCC50 #PedsICU and perhaps targetting cell death.
Typpo: SARS first reported December 13, 2019, entire genome sequenced and reported January 10, 2020 #CCC50 #PedsICU
• • •
Missing some Tweet in this thread? You can try to
force a refresh
