Thread by @pccm_doc

Sevransky: rationale for Vitamin C in sepsis and shock #CCC50 #PedsICU

Sevransky: CITRIS-ALI #CCC50 #PedsICU 167 patients with Sepsis AND ARDS for < 24 hours.

Sevransky: it did raise Vitamin C levels but didn't modify SOFA or other scores. But interventional group had a lower mortality (not a primary outcome measure of the study though, one of 46 secondary measures) #CCC50 #PedsICU Billiard analogy of calling your shot -

Sevransky: VITAMINS study used same dose as Marek study, but placebo was Hydrocortisone #CCC50 #PedsICU

Sevransky: no differences In groups in VITAMINS #CCC50 #PedsICU

Sevranksy: ACT study, comparitor was placebo, steroids were exclusion #CCC50 #PedsICU more "shock free days" but received three therapies

Sevransky: VICTAS study planned for 2000, but funding lapsed after 500 patients #CCC50 #PedsICU comparitor was placebo, same three drug cocktail, primary outcome vasopressor free ventilator free days

Sevransky: inclusion criteria, adaptive that would only stop early if it achieved an early primary outcome measure #CCC50 #PedsICU

Sevransky: intent to treat analysis, no difference between baseline characteristics #CCC50 #PedsICU

Sevransky: no difference in mortality In VICTAS #CCC50 #PedsICU

Sevransky: corticosteroids may play a role in the differnce in some of these studies #CCC50 #PedsICU

Sevransky: conclusion on Vitamin C in Septic Shock #CCC50 #PedsICU