MUCH SHORTER EXPOSURE— #B117 is so infectious—very short exposure can lead to #COVID19. Many infected via just a few minutes inside a store. 🇨🇦 local health dept has shortened the exposure time to as little as ***1 second if not wearing face masks**. 🧵 theglobeandmail.com/canada/article…
2) spokeswoman for Ontario Health Minister Christine Elliott said on Sunday that the government has provided interim guidance to the province’s public-health units for screening and tracing contacts of cases associated with COVID-19 variants of concern.
3) “This guidance does include a lower threshold for classifying contacts as high risk of exposure and requiring quarantine,”
4) Contact tracers in York Region are finding that some individuals who have tested positive for the highly contagious variant have been in a retail store for just a few minutes. ⚠️
5) “Right now, we’re struggling to get to each person within 24 hours,” Dr. Lee told reporters on Friday. “I honestly believe that we are going to be continuing to be overwhelmed with more and more cases.”
6) Meanwhile in UK, #B117 has taken over the country’s cases. Literally. Just that more infectious than the old.
10) I want to take a moment to contextualize — it’s not that we ever thought <15 minutes of contact within 6 feet was safe & 15:01 was not, but that we had to create an arbitrary gradient for reasonable definition for close contact for the original virus, to capture highest risk.
11) And it was to make contact tracing & quarantining manageable scale. But we have known for a while that the 6 feet (2 meter) rule is not very meaningful if there is aerosol transmission, especially indoors with poor ventilation. The coronavirus is very much airborne folks.
12) And thus, the 6 feet rule should have been taken out / guidelines updated long ago for indoor transmission and definition of close contacts. And that was to a degree a failure of leaders to acknowledge and act on that, in the name of managing contact tracing.
13) At this point, with more infectious #B117 variant, it is high time we recognize a new definition of close contact, depending on: masking, indoor/outdoor, time if indoors, ventilation indoors; distance outdoors—and then assign gradients on red, orange, yellow close contacts.
14) And then take precautions for each type of red/orange/yellow “close contacts”. Trace certain ones quicker, quarantine certain ones longer & more aggressively, tests certain ones more repeatedly, and require greater monitoring for the first degree “redder” contacts.
15) As for schools, we DEFINITELY need kids to mask if we reopen. Kids, even if less susceptible than adults, do transmit (@dgurdasani1 and I have entire long long 🧵s on this) and transmit more. And as an epidemiologist, I cannot endorse indoor cafeterias. Outdoor tents please.
16) Wedding dinner parties (god forbid) should avoid indoor events too. So crowded school cafeterias cannot be possibly safe — I have seen ZERO evidence or arguments how cafeterias can be safe without major overhaul. Why can’t we construct / assemble more outdoor tents meantime?
17) And yes, outdoor tents cost money, but they cannot be THAT much more to acquire—and cities/states/federal govt should fund them. If it means we can reopen schools — with outdoor (well ventilated) tents for lunch cafeteria— I’m sure there is a way if we can then open schools.
18) Like every parent with young kids can understand—getting kids back is school is of paramount importance. We can mitigate risk in classrooms with HEPA filters, masks, & maybe safe UV HVAC upgrades if we can afford—but SCHOOL CAFETERIAS we likely can’t without outdoor tents ⛺️!
19) And for those who say “just send kids to school for half days without cafeteria lunches or classroom lunches”—that’s not enough schooling for kids for just half day. I1st-12th graders cannot do half days like kindergarteners and get enough education. We need real solutions.
20) Thus, going forward—We should demand to see real solutions in school reopening plans to address LUNCHROOM SAFETY. Kids can’t mask while eating lunch, and you can’t do no-mask indoors. Either uber-ventilate/disinfect cafeterias or just MOVE LUNCHES OUTDOORS’
21) Another idea if we have school indoor cafeterias, is to either install upper air UV (used in many restaurants that circulates air to ceiling where UV lights are safely pointed), or bring a pair of huge air flow tubes to outside that ventilated the cafeteria at high speed.
22) I also like the idea of summer schools with outdoor learning. Also, more people vaccinated by summer too. But cafeteria / lunchroom dining safety still key.
23) When you watch the SuperBowl this weekend, remember the season was saved because the NFL knew the 15 minutes + 6 ft rule was wrong. The coronavirus gospel of ‘within six feet for more than 15 minutes’ wasn’t enough—and the NFL had the data to prove it. wsj.com/articles/super…
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BREAKING—FDA suddenly cancels meeting to update next season’s flu vaccines, with zero explanations. Any delays will jeopardize next year’s vaccine supply chain.
2) Folks who follow me know that I’m no bullshitter. I criticized past pandemic response right and left, and have called balls and strikes without bias. And I often say things that doctors & epidemiologists are whispering among themselves but don’t say publicly. (Cough cough) ⬇️
3) While I don’t recommend hoarding… I think stocking up on flu antivirals, which you can obtain prophylactically (preventively) from doctors if you ask nicely why you’re high risk, can be a good idea. I know many doctors, epidemiologists and virologists who do for their family.
Doctors are debunking RFK Jr’s claim that 20 hospitalized measles cases in Texas are there for mainly quarantine. Doctors on the ground say the 20 kids hospitalized are having trouble breathing. Oh and they are all unvaccinated against measles, which RFK Jr neglects to mention.
2) RFK Jr told Trump today there’s now 2 measles deaths.
Woke or biology? There are actually more than the basic “male” XY & “female” XX sexes. Why? Because biology also creates people with single X chromosomes, or extra chromosomes like XXX, XXY, XYY, or XXX+, plus many 🧬genes. 👉All I’m asking is— please be kind to others. Thanks🙏
2) “The most frequent SCAs include Turner syndrome (45,X), Klinefelter syndrome (47,XXY), Trisomy X syndrome (47,XXX), and Double Y syndrome (47,XYY).”
3) “The phenotype seen in SCAs is highly variable and may not merely be due to the direct genomic imbalance from altered sex chromosome gene dosage but also due to additive alterations in gene networks and regulatory pathways across the genome as well as individual genetic modifiers.”
I'm shocked a lot of doctors don't know about this newer flu antiviral drug called Baloxavir (XOFLUZA)... that shortens your flu illness by 33%, and reduces your viral load by day 2, versus what a placebo takes 5-6 days to achieve. Baloxavir also seems superior to TAMIFLU (oseltamivir) for smashing your viral load on 2 day, achieving what takes Tamiflu 3-4 days. CDC even lists Baloxavir on their website as one of the top 4 drugs that it tracks whether it works against new flu strains (it works)
2) "Baloxavir was associated with significantly more rapid declines in infectious viral load than placebo or oseltamivir (Figure 3A and 3B)." nejm.org/doi/full/10.10…
3) Adverse events for baloxavir were no different than placebo. in fact theres even hints that it could be lower than Tamiflu.
"Adverse events that were considered to be related to the trial regimen were more common in oseltamivir recipients (8.4%) than in baloxavir recipients (4.4%, P=0.009)"
⚠️WORST FLU SEASON ever since 2002-2003 when we began to track flu (red, first graph). Worst hit this year are children ages 0-4 and 5-17. ▶️We also have significantly LOWER flu vaccine uptake this year, one of the lowest flu vaccine coverages (red 3rd graph). Indisputable facts.
2) I don't need to tell you that certain US states have vastly lower vaccination rates than others. See map (lighter green, less flu vaccination coverage), and which have higher (darker green)...
If you want to see details and demographics on which state has the LOWEST flu vaccine coverage rates... the data is here. cdc.gov/fluvaxview/das…
3) It’s not just the flu that is going around… Gaines County, TX, where the epicenter of the measles outbreak is, has one of the lowest measles vaccination rates too.