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Eric Feigl-Ding Profile picture
@DrEricDing
Feb 4, 2021 • 10 tweets • 6 min read • Read on X
Fauci: “We have to be concerned about the mutants” 👀

He’s right on the concern for the #B117, #B1351, #P1. Plus the B117+E484K mutant combination is worrisome. #COVID19

2) Here are the mutations within each of the 3 standard variants. But the #B117 has also acquired the bad E484K mutation found in the SA and Brazil variants in a new B117 sublineage in Wales 🏴󠁧󠁢󠁷󠁬󠁳󠁿 and England. E484K is the bad one. Image
3) here is the detailed thread 🧵 of the new sublineage of B117 + E484K
4) and anyone with science degree or an X-men movie fan would know mutations are predictable when millions infected.
5) 5) the E484K is the really bad mutation that gives the new variants that have it a degree of antibody immunity evasion. Not complete, but at least partial. This thread 🧵 gives you a rundown... ?
6) South Africa CDC found that of 44 people tested who had COVID last spring, when their blood (with antibodies) was tested against the new #B1351 variant pseudo virus, almost half had complete immune escape. 90% of them also had lower antibody binding.
7) moreover, the new E484K in B117 seems to have evolved separately in 2 different lineages of #B117 & somehow both **convergently evolved** to find E484K. here is the genome lineage @nextstrain map—one evolved in 🏴󠁧󠁢󠁷󠁬󠁳󠁿 and one separately in 🏴󠁧󠁢󠁥󠁮󠁧󠁿. Bad sign when you see convergence. Image
8) There is also a new preprint study that shows the Frankenstein #B117 + E484K has greater resistance to attempts at antibody neutralization (figures shows more antibodies needed to neutralize different types of the pseudovirus in lab experiment with the mutation). Image
9) Please take EXTRA precaution. Double mask with at least one being surgical or better grade, or switch to premium masks please ASAP.
10) Fauci was talking in the video above about this new stunning finding...

we are back to SQUARE ONE if we don’t stop these damn variants with tricky mutations that evade even our previous antibodies. look at what fresh hell we discovered this week...

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More from @DrEricDing

Eric Feigl-Ding Profile picture
Feb 26
BREAKING—FDA suddenly cancels meeting to update next season’s flu vaccines, with zero explanations. Any delays will jeopardize next year’s vaccine supply chain. Image
2) Folks who follow me know that I’m no bullshitter. I criticized past pandemic response right and left, and have called balls and strikes without bias. And I often say things that doctors & epidemiologists are whispering among themselves but don’t say publicly. (Cough cough) ⬇️
3) While I don’t recommend hoarding… I think stocking up on flu antivirals, which you can obtain prophylactically (preventively) from doctors if you ask nicely why you’re high risk, can be a good idea. I know many doctors, epidemiologists and virologists who do for their family.
Read 6 tweets
Eric Feigl-Ding Profile picture
Feb 26
Doctors are debunking RFK Jr’s claim that 20 hospitalized measles cases in Texas are there for mainly quarantine. Doctors on the ground say the 20 kids hospitalized are having trouble breathing. Oh and they are all unvaccinated against measles, which RFK Jr neglects to mention. Image
2) RFK Jr told Trump today there’s now 2 measles deaths.
3) RFK Jr is a tear with his FDA today. A dark Darwinian future lies ahead for America.
Read 4 tweets
Eric Feigl-Ding Profile picture
Feb 26
BREAKING—Reports coming in about potentially *2 measles deaths* in Texas, not just one, according to an HHS briefing to the White House today.
2) Earlier today, one measles death in an unvaccinated child was reported in Texas. Image
3) It seems to be RFK Jr who said it in an official Trump WH cabinet meeting today. Not saying he doesn’t lie, but he is now HHS Secretary
Read 6 tweets
Eric Feigl-Ding Profile picture
Feb 21
Woke or biology? There are actually more than the basic “male” XY & “female” XX sexes. Why? Because biology also creates people with single X chromosomes, or extra chromosomes like XXX, XXY, XYY, or XXX+, plus many 🧬genes. 👉All I’m asking is— please be kind to others. Thanks🙏 Image
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2) “The most frequent SCAs include Turner syndrome (45,X), Klinefelter syndrome (47,XXY), Trisomy X syndrome (47,XXX), and Double Y syndrome (47,XYY).”

pmc.ncbi.nlm.nih.gov/articles/PMC10…
3) “The phenotype seen in SCAs is highly variable and may not merely be due to the direct genomic imbalance from altered sex chromosome gene dosage but also due to additive alterations in gene networks and regulatory pathways across the genome as well as individual genetic modifiers.”
Read 5 tweets
Eric Feigl-Ding Profile picture
Feb 16
I'm shocked a lot of doctors don't know about this newer flu antiviral drug called Baloxavir (XOFLUZA)... that shortens your flu illness by 33%, and reduces your viral load by day 2, versus what a placebo takes 5-6 days to achieve. Baloxavir also seems superior to TAMIFLU (oseltamivir) for smashing your viral load on 2 day, achieving what takes Tamiflu 3-4 days. CDC even lists Baloxavir on their website as one of the top 4 drugs that it tracks whether it works against new flu strains (it works)Image
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2) "Baloxavir was associated with significantly more rapid declines in infectious viral load than placebo or oseltamivir (Figure 3A and 3B)."
nejm.org/doi/full/10.10…
3) Adverse events for baloxavir were no different than placebo. in fact theres even hints that it could be lower than Tamiflu.

"Adverse events that were considered to be related to the trial regimen were more common in oseltamivir recipients (8.4%) than in baloxavir recipients (4.4%, P=0.009)"Image
Read 13 tweets
Eric Feigl-Ding Profile picture
Feb 14
⚠️WORST FLU SEASON ever since 2002-2003 when we began to track flu (red, first graph). Worst hit this year are children ages 0-4 and 5-17. ▶️We also have significantly LOWER flu vaccine uptake this year, one of the lowest flu vaccine coverages (red 3rd graph). Indisputable facts. Image
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2) I don't need to tell you that certain US states have vastly lower vaccination rates than others. See map (lighter green, less flu vaccination coverage), and which have higher (darker green)...

If you want to see details and demographics on which state has the LOWEST flu vaccine coverage rates... the data is here.
cdc.gov/fluvaxview/das…Image
3) It’s not just the flu that is going around… Gaines County, TX, where the epicenter of the measles outbreak is, has one of the lowest measles vaccination rates too.
Read 7 tweets

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