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Shane Crotty Profile picture
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5 Feb, 4 tweets, 3 min read
Hooray, the shiny colorful final version of our paper is out in Science! 😁🧡
science.sciencemag.org/content/371/65…
Explainer thread when it was first published in Science:
And the even earlier story in the NYT by @apoorva_nyc

Thanks to the LJI team! @SetteLab @Dani6020 @Alba_Grifoni @EOSaphire @ljiresearch and everyone else on the LJI and UCSD teams. Plus great help from @florian_krammer and @VivianaSimonLab !

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More from @profshanecrotty

Shane Crotty Profile picture
4 Feb
Getting lots of questions about COVID vaccine safety, which is good! Here's a quick compilation of some resources on COVID vaccine safety.🧡
This covers the basics about the RNA vaccines and safety:

I did a Youtube video on RNA vaccines and COVID vaccine safety with the excellent @MedCramVideos . It has been very popular
(over 1 million views!)
Read 8 tweets
Shane Crotty Profile picture
2 Feb
SIX successful COVID-19 vaccines! SIX! Three just in the past week! Extraordinary. The newest one is the Russian (Rus) adenoviral (Ad) vector COVID vaccine. The clinical trial data look really good at face value. 🧡

doi.org/10.1016/S0140-…
92% efficacy overall, and 92% efficacy in people over 60 years old.
I will let clinical trial design experts weigh in on trial design features. I will comment on the basic outcomes and the immune responses.
Read 12 tweets
Shane Crotty Profile picture
2 Feb
What about vaccinating people who have already had COVID? I get this question a lot. New answers now! 🧡
nytimes.com/2021/02/01/hea…
Excellent and rapid work to find that, for people who have previously had COVID, one COVID vaccine dose gives a bigger antibody response than seen in COVID-negative people receiving a normal two dose COVID vaccine regimen.
One study by Viviana Simon & @florian_krammer and colleagues. And an independent stduy by Sajadi and colleagues in Maryland.
Read 15 tweets
Shane Crotty Profile picture
30 Jan
1/ Now for the thornier data.
2/ I covered the great news from the Novavax COVID vaccine UK Phase 3 trial.
3/ I covered the excellent news from the J&J COVID vaccine Phase 3 international trials.
Read 28 tweets
Shane Crotty Profile picture
29 Jan
1/ J&J COVID-19 vaccine. Single dose Ad26 (adenoviral).

Another important COVID-19 vaccine success!

Topline J&J vaccine efficacy reported to be 100% against serious cases of COVID-19 more than 28 days after immunization. Those are big!
1/n
bit.ly/3tb7K5d
2/ That includes USA, Latin Amer, and South Africa study sites. It will be important to see more data, because the initial press release was definitely thin on data. But, initial report 72% efficacy against "moderate to severe" disease. That is good for a single dose immunization
3/ The J&J COVID-19 vaccine generated good immune responses in people after one immunization, but there was a substantial boost to the antibody response after a 2nd immunization. A 4x gain. (T cell responses after the 2nd dose were not reported)
nejm.org/doi/10.1056/NE…
Read 15 tweets
Shane Crotty Profile picture
29 Jan
1/ Novavax UK first:
~90% protection again any symptomatic COVID-19. And that high level of protection was accomplished under conditions of very intense community transmission in the UK, which is a high bar. 1/n
bit.ly/3oEpann
2/ (i.e., most likely a higher bar for protection than USA summer transmission, or anywhere with low level SARS2 transmission). And that was under conditions of high prevalence of the "UK variant" (B117), which is significantly more transmissible than the parental SARS2 strain.
3/ The Novavax vaccine was quite protective against both the parental strain and the UK variant, which is welcome news.
Read 15 tweets

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