1/ Tocilizumab appears to reduce the risk of death in those hospitalized with severe #COVID19 infection, with results from the RECOVERY trial available today.
This is an anti-inflammatory/immunosuppressive medication, used in rheumatic diseases.
👇👇👇
bit.ly/3p7725v
This is an anti-inflammatory/immunosuppressive medication, used in rheumatic diseases.
👇👇👇
bit.ly/3p7725v
2/
2022 patients were randomized to receive tocilizumab; 2094 to receive standard care. 80% of the participants were using dexamethasone.
596 (29%) in the tocilizumab group died within 28 days VS 694 (33%) in the usual care group.
2022 patients were randomized to receive tocilizumab; 2094 to receive standard care. 80% of the participants were using dexamethasone.
596 (29%) in the tocilizumab group died within 28 days VS 694 (33%) in the usual care group.
3/
"Tocilizumab also increased the probability of discharge alive within 28 days from 47% to 54% (rate ratio 1.23, [95% CI 1.12 to 1.34], p<0.0001)."
"This means that for every 25 patients treated with tocilizumab, one additional life would be saved."
"Tocilizumab also increased the probability of discharge alive within 28 days from 47% to 54% (rate ratio 1.23, [95% CI 1.12 to 1.34], p<0.0001)."
"This means that for every 25 patients treated with tocilizumab, one additional life would be saved."
4/
This is likely enough evidence to shift the balance toward more tocilizumab use for severe #COVID19 infections in hospital settings, especially in the ICU.
Also, if you are going to share data by press release, this is the right way to do it.
This is likely enough evidence to shift the balance toward more tocilizumab use for severe #COVID19 infections in hospital settings, especially in the ICU.
Also, if you are going to share data by press release, this is the right way to do it.
Addendum:
It is pronounced: "toe-see-li-zoo-mab" by some, "taw-si-li-zoo-mab" by others, or even "taw-see-li-zoo-mab".
This may spur some heated debate.
It is pronounced: "toe-see-li-zoo-mab" by some, "taw-si-li-zoo-mab" by others, or even "taw-see-li-zoo-mab".
This may spur some heated debate.
But as always, the fine print is important - let's see the data.
Also this drug costs a fortune. Does it provide meaningful benefit? And how much & in whom?
My guess is it will be used in ICUs more than elsewhere, but would love to hear what others think.
Also this drug costs a fortune. Does it provide meaningful benefit? And how much & in whom?
My guess is it will be used in ICUs more than elsewhere, but would love to hear what others think.
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