Thread by @GardnerPhD

1/9
Just completed trial
Keto vs Mediterranean

Just submitted Design & Adherence paper PRIOR to main results paper

While waiting for reviews & decision…
 ~10 weekly mini-threads - #KetoMedStudy

⬆️design understanding &
⬆️twitter civility?🙏
 
Week #1
Main study question

2/9
US calories: 1999-2016
pubmed.ncbi.nlm.nih.gov/31550032/

Low quality carbs
Added sugars, refined grains: ~40%

High quality carbs (whole grains, legumes, fruits): ~10%

3 types fat: ~10% each

Protein: Animal ~10%; plant ~5%

***Biggest impact potential - ⬇️ low quality carbs

3/9
Most/all healthy diet patterns recommend avoiding/minimizing added sugars & refined grains, while including non-starchy vegetables

Is there additional overall health benefit to also eliminating:
*Legumes/beans
*Whole intact grains
*Fruits

Poll next tweet

4/9

Hmmm.....would have preferred poll with 5 choices, but limited to 4. Will collapse two categories from previous.

POLL QUESTION: In addition to eliminating added sugars and REFINED grains, there is an additional benefit to eliminating:

5/9
Introducing #KetoMedStudy Design

A crossover RCT comparing 2 metabolically distinct diets
1) Well Formulated Ketogenic Diet
vs
2) Mediterranean-Plus Diet
(to be defined)
 
Among individuals w/ T2DM or prediabetes for effects on blood glucose

Primary outcome ➡️ HbA1c

6/9
Reporting adherence is SUPER important in studies comparing Diet A vs Diet B, as we discussed in @AJHPOfficial
journals.sagepub.com/doi/full/10.11…
 
BUT it’s also really tough to define and measure adherence. 😅

7/9
We had SO much cool data on adherence to diets, there was NO WAY it would fit in the main outcomes paper.
 
So our lab made a DEDICATED adherence paper.
While it’s in review, we’ll share bits of the study each week.
@TheGuyititian
@LuciaAronica
@dalita
@sunkimmd
@GardnerPhD

8/9
The study wasn’t perfect. 🤷🏼‍♂️
We had to make modifications because of Covid.😪
We’ll talk about some of that.
 
We want to see what the Twitterverse thinks of our definitions of adherence, our scoring criteria, the level of adherence we got, and more. 🤔

9/9
See ya next week for installment #2 of #KetoMedStudy

@TheGuyititian
@LuciaAronica
@dalita
@sunkimmd
@GardnerPhD