Certain “experts” should be quite ashamed for pushing fear mongering tweets and using misleading studies to fit their rhetoric concerning the efficacy of these vaccines. Since they rely on the fact most will not understand the studies since it’s not in layman’s terms allow me. 🧵
Firstly, the conclusions being drawn from this study and this “expert” is that the B.1.1.7 and B.1.351 variants would render these vaccines ineffective. This is highly unlikely. It will take a large amount of genetic diversity to completely render the current vaccines useless.
Not to mention Ding is using an older study to push this rhetoric when Pfizer and Moderna have recently established their vaccines will be effective against these variants. Perhaps someone should pass THOSE studies onto him. For the record, if you’re going to claim these vaccines
are ineffective the last thing you should attempt to utilize to push your rhetoric is a study that concerns monoclonal antibodies. Why? Vaccines are polyclonal. Unlike monoclonal antibody therapies, vaccines (especially those utilizing the whole spike protein) make polyclonal
antibody responses. This means that the antibodies you make after vaccination will be able to bind the coronavirus spike in multiple places not just one. You cannot possibly attempt to relate the effectiveness of a monoclonal antibody treatment against these variants to the
vaccines, don’t even try. Two independent platforms. Carrying on. Secondly, the study looks at OLD (Spring 2020) blood sera from NATURAL infection. Therefore they already contained low antibody levels. Why is this an issue? Because everyone knows antibodies from natural infection
with COVID do wane eventually so of course neutralization assays are going to be low? Next, the vaccine sera neutralization assays. Taken from participants shortly after their second dose. I’m not sure what researchers expected. Does anyone realize immunity is not instantaneous?
Key fact, you have to allow the vaccine time to work and take effect before you just dive in there and measure nAbs. They don’t just spring up like daffodils. Measuring them at the intervals this study did no wonder why they saw the antibody titers they did. Not to mention the
study TOTALLY disregarded T-cells. Once again. How are you going to disregard our actual immune systems and their ability to make antibodies for later? Which may I remind you are DRIVEN by vaccines. They teach our bodies to make antibodies for later, not just during active
infection (memory T-cells anyone). That’s immunity! T-cells stimulate B-cells to make antibodies. Antibodies are just your first line of defense which is what is initiated when you get this vaccine. It’s our T-cells that are responsible for long-term immunity. When antibodies
diminish after your initial inoculation, your T-cells-will tell your B-cells it’s time to produce more antibodies. As long as your T-cells still recognize this virus and inform your B-cells they need to produce antibodies, the vaccine is still doing its job.
Antibodies being built up over and over again is nothing new or unique-to this vaccine, this is how vaccines have always worked. This study does not account for this information concerning T-cell immunity AT ALL. The study being utilized is here.
biorxiv.org/content/10.110…
So do me a favor, if you don’t have the ability to gain traction on your tweets without being completely transparent then don’t tweet it. I only wrote this up because I’m tired of seeing it circulate. It’s misleading. Know your facts. This study ignores the general basic science
and understanding of the immune system and how these vaccines work and their effectiveness against these variants as does this individual apparently. I have people in my DMs fearing about protection after being vaccinated due to tweets like his. I implore you, do not give

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More from @sailorrooscout

17 Feb
I want to bring this up. I’m sure by now you have seen those sensationalist headlines about variants merging and “heavily mutated hybrids” and what not. Guess what I want you to do right now? Ignore them. Yes, ignore them. Know why? Things like this are just mass hysteria. Image
The ones we need to be paying attention to are B.1.1.7, B.1.351 and P.1 because these are the only known SARS-CoV-2 variants that HAVE been shown to possess any evidence of functional significance or biological properties that make them a cause for concern to date. The rest?
Forget them. I read one article and I quote: “the recombination event may have occurred within the sample after it was taken from the infected person, not while it was inside their body. In which case it is an accidental laboratory artefact, not a wild virus.” Makes my head hurt.
Read 6 tweets
17 Feb
A new study out of Harvard offers evidence that SARS-CoV-2 variant B.1.1.7’s increased transmissibility isn’t due to its viral load but rather it’s delayed clearance, resulting in longer duration of infection. The implications are extremely positive. 🧵
dash.harvard.edu/bitstream/hand…
This could potentially mean a longer personal isolation period (longer than the currently recommended 10 days after symptom onset) may be all that is needed to control the spread of B.1.1.7! Image
For individuals infected with B.1.1.7, the mean duration of the proliferation phase was 5.3 days, the mean duration of the clearance phase was 8.0 days, and the mean overall duration of infection (proliferation plus clearance) was 13.3 days.
Read 5 tweets
17 Feb
Let’s discuss SARS-CoV-2 variants, selective pressure, and mutations. In the face of variants, our best protection is to get more people vaccinated. Vaccination will not automatically select for vaccine-resistant variants, especially if we can reduce transmission. Here’s why. 🧵
First, it is important to realize these vaccines will not drive the emergence of new variants and compel this virus to mutate in novel ways (OR create some scary super mutant so throw that idea out the window). I think this where a lot of the confusion lies- it’s not possible.
The specific mutations we are currently witnessing focus on altering the fitness of this virus by improving its rate of transmission with some signs of immune evasion. Mutation is a fairly constant process to begin with. It occurs randomly when a virus replicates and trust me,
Read 14 tweets
15 Feb
That’s not how this works.
That’s not how any of this works.
Viruses need one thing to mutate: a host. Protect the host, stop the mutations. We REALLY need to stop giving these people platforms when it’s blatantly obvious they have no idea what they’re freaking talking about.
For those asking what the issue is. This is a VERY misguiding message. Let me put it this way because no one is stating such even though they should be: it is FAR less likely for variants to occur in a vaccinated population than an unvaccinated population. Why? To put it simply:
This is basic virology. This virus isn’t exhibiting stress-induced mutagenesis. It is adapting solely to increase its fitness and that’s what it is selecting its mutations for- it isn’t adaptive immune pressure. This is happening only due to the fact it is infecting more people.
Read 7 tweets
15 Feb
More promising mRNA vaccine data!
This time from Moderna. A new Phase II study shows that half-doses (50 μg) of our vaccine appear to be as effective as full doses (100 ug) at eliciting robust immune responses in the form of neutralizing antibodies.🧵
sciencedirect.com/science/articl…
Participants were stratified into two age cohorts (≥18-<55 and ≥55) and were randomly assigned (1:1:1) to either 50 or 100 µg of mRNA-1273, or placebo administered as two intramuscular injections 28 days apart.
The primary outcomes were safety, reactogenicity, and immunogenicity assessed by anti-SARS-CoV-2-spike binding antibody level (bAb). Secondary outcome was immunogenicity assessed by SARS-CoV-2 neutralizing antibody (nAb) response. Participants had no history of infection.
Read 10 tweets
14 Feb
Good mRNA vaccine news this morning! Ben Osborn, the UK head of Pfizer, said they do not expect to have to change their vaccine to handle SARS-CoV-2 variants B.1.1.17 and B.1.351 due to no drop in efficacy! Let’s talk about variants, vaccines, and why you shouldn’t panic. 🧵
Firstly, we can agree media response to the variants has been overblown and become a huge source of misinformation unfortunately. For some context: you are going to read and hear about a TON of variant viruses, because viruses mutate by nature. Not every single one is a concern.
While I know it’s scary and a lot is “unknown,” a couple of amino acids is not the same a whole whole new virus strain in the way that we’ve been taught to think about influenza. RNA viruses by nature mutate more readily than DNA viruses. Not to mention, SARS-CoV-2 doesn’t
Read 14 tweets

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