122. Revenge of the Sirotkins & hACE2 Mice!
onlinelibrary.wiley.com/doi/10.1002/bi…
This is a "clarification regarding likely leak of a novel viral strain from a Soviet lab" after being harassed by DARPA for publishing:
"Might SARS‐CoV‐2 Have Arisen via Serial Passage?"
onlinelibrary.wiley.com/doi/10.1002/bi… ImageImageImageImage
123. Don't waste your time with the WHO Press Conference in Wuhan, just read this new paper instead:
Open debate on SARS-CoV-2's proximal origin
arxiv.org/abs/2102.03910
@Rossana38510044 @ydeigin @KevinMccairn @Harvard2H @jjcouey @Daoyu15
24 page PDF:
arxiv.org/ftp/arxiv/pape… Image
124. My Two Blind Transgenic Mice Threads
1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice

2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2!
125. Domains and Functions of Spike Protein in SARS-CoV-2 in the Context of Vaccine Design
via @TheSeeker268
"the claim that the polybasic furin cleavage site in SARS-CoV-2 has been experimentally inserted is not too far‐fetched."

mdpi.com/1999-4915/13/1… Image
126. SARS-CoV-2 and the Secret of the Furin Site:

preprints.org/manuscript/202…

"The million-dollar question: would a bat coronavirus RatG13, isolated in 2021, have the functional polybasic furin site?" (or like a few years earlier?) via @TheSeeker268 Image
127. Decoding Covid-19 with the SARS-CoV-2 Genome
link.springer.com/article/10.100…
"arguments exist that challenge the zoonotic origin of SARS-CoV-2 and, instead, suggest that the virus may not have a natural origin." ImageImageImageImage
128. Thanks for the reminder from @JohnGal52793009
"Vector sequences in early WIV SRA sequencing data of SARS-CoV-2 inform on a potential large-scale security breach at the beginning of the COVID-19 pandemic"
Daoyu Zhang @Daoyu15 ex- @flavinkins
zenodo.org/record/4486195… ImageImageImageImage
129. @netpoette is back with a comprehensive update
Frustrated by the superficiality & bias of recent press conferences about the possible #origin of #SARS-CoV-2? This article is extremely detailed & comprehensive & updated
changingtimes.media/2020/10/12/sar… ImageImageImageImage
130. Why China and the WHO Will Never Find a Zoonotic Origin For the COVID-19 Pandemic Virus
by Jonathan Latham, PhD and Allison Wilson, PhD
independentsciencenews.org/commentaries/w…
131. Anon, A, Bostickson, B, & Demaneuf, G. (2021) Investigation into Wuhan Institute of Virology Pathogen Databases (Version 2). Zenodo. doi.org/10.5281/zenodo…
zenodo.org/record/4512260…
24 Page on the Missing Databases
My first Paper but not my last, I can assure you! ImageImageImageImage
132. A Bayesian analysis concludes beyond a reasonable doubt that SARS-CoV-2 is not a natural zoonosis but instead is laboratory derived
Quay MD PhD, Steven Carl @quay_dr
zenodo.org/record/4477081…
Massive 193 Pages
Includes a Free Zenodo Warning (never see that before) ImageImageImageImage
133. The German Paper (includes #DRASTIC 50 questions)
Study on the origin of the coronavirus pandemic
researchgate.net/publication/34…
From Roland Wiesendanger's Lab
via @Florian_Hanover and @bej_gff
Study published on the origin of the coronavirus pandemic
uni-hamburg.de/newsroom/press… ImageImageImageImage
134. A thorough analysis and debunking of anti-lab leak arguments by @espo_francesco
Anthropogenic origin of SARS-CoV-2 pandemic
zenodo.org/record/4589116… Image
135. SARS-CoV-2 and the Secret of the Furin Site
preprints.org/manuscript/202…
via @gerdosi
Reviewed here:
news-medical.net/news/20210217/…

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More from @BillyBostickson

May 9
“We are not a Cult”

DRASTIC and the investigative network that broke the Corona laboratory taboo

Must Read Interview!

The hard working "Two Ronnies" of DRASTIC

@gdemaneuf & @BillyBostickson

Interviewed by @franzbecchi for @berlinerzeitung

berliner-zeitung.de/politik-gesell…
1. Who are the “pandemic detectives”?

We speak with 2 of DRASTIC's prominent members:

@gdemaneuf (a data scientist & engineer)

and @BillyBostickson, longtime activist who was formerly part of opposition networks in China & HK & who operates anonymously for security reasons.
@gdemaneuf 2. My Responses

How did DRASTIC come about?

I started in January 2020, triggered by an article by Dan Sirotkin on the origins of the virus.

I connected with people like @R_H_Ebright & others on Twitter.

In May 2020, I chose the name "DRASTIC" for this decentralized group.
Read 18 tweets
May 8
22. Biased Sampling distorts Geography!

They use a dataset skewed toward Yunnan & Laos (p. 16), leading to phylogeographic models that place SARS-CoV ancestors far from Wuhan & Guangdong (p. 12).

This sampling bias undermines the reliability of their geographic inferences.
23. Neglecting Alternative Hypotheses

No SARS-CoV-like viruses near emergence sites?

They completely overlook non-bat reservoirs, like civets or pangolins, which could explain local circulation (p. 15).

This omission weakens their claim of distant ancestor origins (p. 12).
24. Inconsistent Molecular Clock Rates

The paper misuses variable NRR-specific clock rates, which give inconsistent SARS-CoV ancestor dates (e.g., 1944–2014 for SARS-CoV-2, p. 9).

Without any validation of bat-specific rates, this approach has no rational grounding (p. 14).
Read 33 tweets
May 8
5. Why did they resort to using the POW model?

To show that :

"our inferences of the time of the ancestors of human SARS-CoVs and their closest bat sarbecoviruses are UNBIASED"
6. Captain Obvious Strikes Again (1)

"we show that the ancestors of SARS-CoV-1 & SARS-CoV-2 likely circulated in horseshoe bat populations 100s to 1000s km away from the sites of the emergence of these viruses in humans & as recently as one to six years prior to this emergence"
7. Captain Obvious Strikes Again (2)

"Our findings indicate that there would not have been sufficient time for the direct bat virus ancestor to reach the locations of emergence of the human SARS-CoVs via normal dispersal through bat populations alone"
Read 12 tweets
May 8
1. Last sick joke of the Zoonati?

Fragments of human SARS-CoVs share recent common ancestors with bat viruses

SARS-CoV-like viruses have circulated in Asia for millennia

Ancestors of human SARS-CoVs likely circulated in China & Laos

Ancestors traveled unexpectedly fast
2. No Pangolins allowed!

There is insufficient temporal signal when calibrating a molecular clock using tip dating with sarbecoviruses sampled from bats & pangolins, likely as a consequence of limited sampling across space & time.

Therefore, we used SARS-CoV-1 genomes!
3. Definitely no pangolins!

As sampling locations of SARS-CoV-1, 2 & pangolin sarbecoviruses likely do not represent where their direct bat virus ancestors circulated, we EXCLUDED their locations from phylogeographic analyses to avoid the IMPACT of dispersal of non-bat hosts!
Read 24 tweets
May 4
1⃣ Virological 🦠 Whistleblower 😮‍💨?

"I worked with researchers in this space - virology + combatting future pandemics - in the decade before the pandemic".
2⃣ One Fact

"The one fact that the last 5 years never readily disclosed is that the core ideology of this community of researchers was fundamentally divided"
3⃣ Lab based creation of super-viruses

"About half of the researchers, including many leading virologists whose names appeared in the news, believed and argued passionately for the lab-based creation of super-viruses and super-bacteria"
Read 12 tweets
Apr 23
1. The Second Lab Leak

Turning and turning in the petri dish,
The scientists cannot hear the warnings;
Genes recombine; the barriers cannot hold,
Evil virology is loosed upon the world,
The blood-dimmed tide is loosed, and everywhere
The ceremony of innocence is drowned;
2. The Second Lab Leak

The best lack critical thinking, while the professors
Are full of furious bias.
Surely some revelation is at hand;
Surely the cover up is now banned?
Lab Leak! Hardly are those words out
When a vast image out of Human Folly
Troubles my sight:
3. Somewhere in Wuhan

somewhere in the cell lines of a Chinese laboratory
A shape with pangolin body and the head of a bat,
A gaze blank and pitiless as the sun,
Is moving its long tongue, while all about it
Reel shadows of the indignant molested bats.
Read 6 tweets

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