WHY A VIRAL DISEASE NEEDS TO BE TREATED WITH NEUROPSYCHIATRIC OR ANTI-INFLAMMATORY DRUGS ?
gaba agonists and sigma agonists taking upper hand in covid treatment
#mytakeoncovid19
link.springer.com/article/10.100…
gaba agonists and sigma agonists taking upper hand in covid treatment
#mytakeoncovid19
link.springer.com/article/10.100…
next potential alternative covid prophylaxis drug
@veryvirology
@Dharmen46587056
@BakhleD
(opinions please)
ITRACONAZOLE-200 mg biweekly for 3-4 month or more
(needs some more evidences)
@veryvirology
@Dharmen46587056
@BakhleD
(opinions please)
ITRACONAZOLE-200 mg biweekly for 3-4 month or more
(needs some more evidences)
https://twitter.com/__ice9/status/1318499355515588609?s=19
IVERMECTIN IS USED
*AS VIRAL GENOME TARGETING ANTIVIRAL, where very high dosage are required to stop viral replication directly(practically difficult)
800-1600mcg/kg body wt/day
*AS HOST DIRECTED ANTIVIRAL, which is very effective,safe and clinically used
150-250 mcg/kg wt/day
*AS VIRAL GENOME TARGETING ANTIVIRAL, where very high dosage are required to stop viral replication directly(practically difficult)
800-1600mcg/kg body wt/day
*AS HOST DIRECTED ANTIVIRAL, which is very effective,safe and clinically used
150-250 mcg/kg wt/day
after rupture of(by virus) a cell, a number of intracellular products come into interstitial space and intravascular compartment
these induce intense inflammatory and immunogenic reaction,forming many toxins and short lived autoantibodies
interacting to clotting mechanism or else
these induce intense inflammatory and immunogenic reaction,forming many toxins and short lived autoantibodies
interacting to clotting mechanism or else
THE LATENT VIRUSES
is coV2 is capable of going into latency?
"In latent infection, full viral genome is retained in host cell, but its expression is dramatically restricted, such that few viral antigens and no viral particles are produced"
ncbi.nlm.nih.gov/pmc/articles/P…
is coV2 is capable of going into latency?
"In latent infection, full viral genome is retained in host cell, but its expression is dramatically restricted, such that few viral antigens and no viral particles are produced"
ncbi.nlm.nih.gov/pmc/articles/P…
TOXIC NEUROPATHY/ENCEPHALOPATHY IN LONG COVID
a sub-thread of long covid protocols
a sub-thread of long covid protocols
https://twitter.com/__ice9/status/1318604188000145408?s=19
IVERMECTIN IN FRENCH MEDIA
World tour of treatments - India, interview with Dr Chaurasia: "ivermectin works"
francesoir.fr/politique-mond…
World tour of treatments - India, interview with Dr Chaurasia: "ivermectin works"
francesoir.fr/politique-mond…
FEW OBSERVATIONS OVER A YEAR IN PANDEMIC
*CONFIRMED THAT HCQ/IVM ARE DOING WONDERS IN COVID
*BOTH HAVE TREMENDOUS SAFETY MARGINS
*SAFETY MARGINS OF IVM PERMITS US TO INCREASE DOSAGE NEARING INHIBITARY CONCENTRATIONS IC-50, 400mcg/kg body wt/day
@Covid19Critical
@Covid19Crusher
*CONFIRMED THAT HCQ/IVM ARE DOING WONDERS IN COVID
*BOTH HAVE TREMENDOUS SAFETY MARGINS
*SAFETY MARGINS OF IVM PERMITS US TO INCREASE DOSAGE NEARING INHIBITARY CONCENTRATIONS IC-50, 400mcg/kg body wt/day
@Covid19Critical
@Covid19Crusher
IVERMECTIN PROPHYLAXIS FOR COVID19
IVERMECTIN 12 mg weekly for 3 months
(ivermectine 200 mcg/per kg body wt/weekly)
HYDROXYCHLOROQUINE PROPHYLAXIS FOR COVID19
HCQ- 400 mg weekly for 6 months
(can be extended if needed)
IVERMECTIN 12 mg weekly for 3 months
(ivermectine 200 mcg/per kg body wt/weekly)
HYDROXYCHLOROQUINE PROPHYLAXIS FOR COVID19
HCQ- 400 mg weekly for 6 months
(can be extended if needed)
SPIRONOLACTONE IN COVID DISEASE
"spironolactone may concurrently mitigate abnormal ACE2 expression"
"suppress androgen-mediated TMPRSS2 activity,and inhibit obesity-related RAAS dysfunctions"
ncbi.nlm.nih.gov/pmc/articles/P…
"spironolactone may concurrently mitigate abnormal ACE2 expression"
"suppress androgen-mediated TMPRSS2 activity,and inhibit obesity-related RAAS dysfunctions"
ncbi.nlm.nih.gov/pmc/articles/P…
SEASONALITY IN COV2- REALITY OR MYTH
a retro study from 2004, re SARS-coV
courtesy @sanchak74
thelancet.com/journals/lanin…
a retro study from 2004, re SARS-coV
courtesy @sanchak74
thelancet.com/journals/lanin…
IVERMECTIN IN INDIA- OBSERVATIONS FROM PAST
"This was no small move.Were it a country,U.P.’s more than 230 million citizens would rank it fifth worldwide. As India’s largest state,its embrace of ivermectin may have changed treatment landscape across India"
trialsitenews.com/the-war-on-mis…
"This was no small move.Were it a country,U.P.’s more than 230 million citizens would rank it fifth worldwide. As India’s largest state,its embrace of ivermectin may have changed treatment landscape across India"
trialsitenews.com/the-war-on-mis…
TREAT COVID, LIKE FLU
(treat every cough with flu formulations)
AZITHROMYCIN+IVM+ETORICOXIB/PARACETAMOL+HYDROXYZINE/MONTELUKAST
(treat every cough with flu formulations)
AZITHROMYCIN+IVM+ETORICOXIB/PARACETAMOL+HYDROXYZINE/MONTELUKAST
this new covid wave needs entirely different strategy to mitigate it.
outline,
*no lockdown
*no compulsory tests requirements
*mass motivation of covid prophylaxis
*treat every cough fever like flu with,
1)IVM+
2)AMOXY/CLAV+
3)IBU/PARA+
4)FEXOFENADINE/MONTELUKAST
5)FAMOTIDIN
outline,
*no lockdown
*no compulsory tests requirements
*mass motivation of covid prophylaxis
*treat every cough fever like flu with,
1)IVM+
2)AMOXY/CLAV+
3)IBU/PARA+
4)FEXOFENADINE/MONTELUKAST
5)FAMOTIDIN
THE SECOND WAVE, NEW STRAINS AND MY WORKSHEET
*virus is attacking abruptly
*giving no time for investigation
*we have treatment already, use it now
*virus is attacking abruptly
*giving no time for investigation
*we have treatment already, use it now
STATE OF JHARKHAND, INDIA,
ALLOWS IVM+DOXY IN EVERY CASE OF RESPIRATORY INFECTION
treat every case of flu, AS COVID
ALLOWS IVM+DOXY IN EVERY CASE OF RESPIRATORY INFECTION
treat every case of flu, AS COVID
DRUGS FOR ACUTE VIRAL PHASE OF COVID DISEASE
https://twitter.com/drakchaurasia/status/1327700732787580928?s=19
KILLING A DRUG BY UNDERMINING TRIALS
*nitazox, a drug with IC-50 at dosage 800 mg twice daily
*conducting trials, using 300mg bid
*is not enough, to kill it in first hand?
prnewswire.com/news-releases/…
*nitazox, a drug with IC-50 at dosage 800 mg twice daily
*conducting trials, using 300mg bid
*is not enough, to kill it in first hand?
prnewswire.com/news-releases/…
PRE AND POST EXPOSURE PROPHYLAXIS
for the attendants and family members of a covid patient
for the attendants and family members of a covid patient
THE FIRST INTERNATIONAL IVERMECTIN, ONLINE CONFERENCE
please make this event a groundbreaking one and help save humanity
please make this event a groundbreaking one and help save humanity
PRE AND POST EXPOSURE PROPHYLAXIS
for the attendants and family members of a covid patient
for the attendants and family members of a covid patient
AIIMS INDIA ENDORSED IVERMECTIN IN COVID
this is ground breaking news for medical fraternity of india
this is ground breaking news for medical fraternity of india
FEW THINGS NEVER CHANGE.......
rather they grow more stronger
rather they grow more stronger
EARLY HOME BASED TREATMENT FOR MILD TO MODERATE COVID CASES
NOTE:- HOME TREATMENT FOR MILD CASES
ANYONE FROM
IVERMECTIN-12 OR HYDROXYCHLOROQUINE-400,
CAN BE USED
ANYONE FROM
IVERMECTIN-12 OR HYDROXYCHLOROQUINE-400,
CAN BE USED
HOME TREATMENT FOR MILD CASES- IN GENERIC NAMES
SECOND COVID WAVE IN INDIA,
EXCESSIVE ANDROGENIC EXPRESSIONS AND NEWER STRAINS
a thread on second wave in india
EXCESSIVE ANDROGENIC EXPRESSIONS AND NEWER STRAINS
a thread on second wave in india
https://twitter.com/drakchaurasia/status/1384455528349196289?s=19
@flavinkins
@OlgaG58726484
@Ustangord
@Covid19Crusher
@Rajnish_IITR
@rajnishgupta59
@Dharmen46587056 @ishan_bhupendra @__ice9
@Thinkerks
@DrSubhasree @amareshskumar
@ICMRDELHI
@Covid19Critical
@BIRDGroupUK
@veryvirology
@BidoliNicola
@debe
@BallouxFrancois
@OlgaG58726484
@Ustangord
@Covid19Crusher
@Rajnish_IITR
@rajnishgupta59
@Dharmen46587056 @ishan_bhupendra @__ice9
@Thinkerks
@DrSubhasree @amareshskumar
@ICMRDELHI
@Covid19Critical
@BIRDGroupUK
@veryvirology
@BidoliNicola
@debe
@BallouxFrancois
nobody other than a physician can understand, what this new strain is.
and what this strain needs to be mitigated.
age 32yrs spO2 95%, despite of all previous regeme, dropped to spO2 82%.
after 7 days of desperate efforts, today he recovered to 97%.
this is 2nd wave of india
and what this strain needs to be mitigated.
age 32yrs spO2 95%, despite of all previous regeme, dropped to spO2 82%.
after 7 days of desperate efforts, today he recovered to 97%.
this is 2nd wave of india
1/2
today, this pt is send to home in satisfactory conditions. follow up needed at least 3 weeks.
(the tentative protocol used in this pt, I'll post after feedback from few more pts.)
today, this pt is send to home in satisfactory conditions. follow up needed at least 3 weeks.
(the tentative protocol used in this pt, I'll post after feedback from few more pts.)
grossly stating, to mitigate fast progression of pulmonary conditions in this pt, drugs used,
*spironolactone+frusemide
*dutasteride+tamsulosin
*inositol-niacin
along with other routine antivirals and anti-inflammatories
*spironolactone+frusemide
*dutasteride+tamsulosin
*inositol-niacin
along with other routine antivirals and anti-inflammatories
REVISED COVID TREATMENT- 1
(this thread is an integrated part of previous covid guidelines, in perspective of newer strains)
*tentative treatment to be started from first symptoms
*treat mild case, assuming it as moderate one
*speed of starting early treatment is the key
(this thread is an integrated part of previous covid guidelines, in perspective of newer strains)
*tentative treatment to be started from first symptoms
*treat mild case, assuming it as moderate one
*speed of starting early treatment is the key
REVISED COVID TREATMENT- 2
*at least two antivirals to be used in full dosage
*treatment for pneumonitis/hypoxia to be started prophylactically, before starting symptoms
*NAC, GLUTATHIONE, SPIRONOLACTONE to be started from beginning
*at least two antivirals to be used in full dosage
*treatment for pneumonitis/hypoxia to be started prophylactically, before starting symptoms
*NAC, GLUTATHIONE, SPIRONOLACTONE to be started from beginning
REVISED COVID TREATMENT- 3
(sample)
*IVM/ HCQ/ FEVIPIRAVIR/ NITAZOX
*AZM/ doxy/ clarithro/ cefuroxim-cv/
*ibuprofen/etoricoxib/ aceclo+ bromelin/tryp-chymo
*levocetrizine+montelukast
*deflazacort/ dexamethasone/ budesonide inhaled
*cyprohep/indomethacin
*famotidine/ rabeprazole
(sample)
*IVM/ HCQ/ FEVIPIRAVIR/ NITAZOX
*AZM/ doxy/ clarithro/ cefuroxim-cv/
*ibuprofen/etoricoxib/ aceclo+ bromelin/tryp-chymo
*levocetrizine+montelukast
*deflazacort/ dexamethasone/ budesonide inhaled
*cyprohep/indomethacin
*famotidine/ rabeprazole
BASIC CONCEPTS OF REVISED IVERMECTIN DOSAGES IN COVID TREAT/PRXIS
*based on calu-3 cells studies, IC- 50 for ivermectin is 400- 800 mcg/kg body wt/day × 7-14 days
*clinical evaluation over a period of 2 weeks, 400 mcg dosage are well tolerated in once or twice daily dasage
*based on calu-3 cells studies, IC- 50 for ivermectin is 400- 800 mcg/kg body wt/day × 7-14 days
*clinical evaluation over a period of 2 weeks, 400 mcg dosage are well tolerated in once or twice daily dasage
RECOMMENDED DOSAGES OF IVERMECTIN IN COVID PROPHYLAXIS
(FOR SECOND WAVE)
IVERMECTIN- 12
2 tabs weekly, with meal for 2 months or more
(FOR SECOND WAVE)
IVERMECTIN- 12
2 tabs weekly, with meal for 2 months or more
#akcprotocolssecondwave
COVID TREATMENT (MILD SEVERITY)
*TAB RABEPRAZOL-40 1 tab bid
*TAB AZITHROMYCIN-500 1 tab od
*TAB IBUPROFEN+PARACETAMOL 1 tab bid
*TAB LEVOCETRIZIN+MONTELUKAST 1tab od
*TAB HCQS-400 1 tab od
*TAB IVERMECTIN-12 2 tabs od
for 7 days, then review
COVID TREATMENT (MILD SEVERITY)
*TAB RABEPRAZOL-40 1 tab bid
*TAB AZITHROMYCIN-500 1 tab od
*TAB IBUPROFEN+PARACETAMOL 1 tab bid
*TAB LEVOCETRIZIN+MONTELUKAST 1tab od
*TAB HCQS-400 1 tab od
*TAB IVERMECTIN-12 2 tabs od
for 7 days, then review
COVID TREATMENT (MODERATE SEVERITY)
*TAB RABEPRAZOL-40 1tab bid
*TAB AZITHROMYCIN-500 1 tab od
*TAB IBU+PCM 1 tab bid
*TAB DEFLAZACORT- 12 1tab od
*TAB AMBRO+N-ACETYLCYSTIENE 1tab bid
*TAB IVM-12 2 tab od
*TAB HCQ-400 1tab od
*TAB SPIRO-50+FRUSEMIDE-40 1 tab od
for 7 days
*TAB RABEPRAZOL-40 1tab bid
*TAB AZITHROMYCIN-500 1 tab od
*TAB IBU+PCM 1 tab bid
*TAB DEFLAZACORT- 12 1tab od
*TAB AMBRO+N-ACETYLCYSTIENE 1tab bid
*TAB IVM-12 2 tab od
*TAB HCQ-400 1tab od
*TAB SPIRO-50+FRUSEMIDE-40 1 tab od
for 7 days
PRE/POST EXPOSURE PROPHYLAXIS(revised)
*TAB HCQS-400 1tab once daily
*TAB ATM-500 1tab once daily
for 7 days
*TAB IVERMECTIN-12 2 tab once daily
*TAB ATM-500 1 tab once daily
for 7 days
*TAB HCQS-400 1tab once daily
*TAB ATM-500 1tab once daily
for 7 days
*TAB IVERMECTIN-12 2 tab once daily
*TAB ATM-500 1 tab once daily
for 7 days
DIGITALIS AS REPLICATION INHIBITOR OF COV2
this study is the end result of my observations, that none of my pt on digitalis contracted covid. mostly rheumatic heart disease cases.
nature.com/articles/s4159…
this study is the end result of my observations, that none of my pt on digitalis contracted covid. mostly rheumatic heart disease cases.
nature.com/articles/s4159…
IVERMECTIN PROPHYLAXIS FOR COVID19
IVERMECTIN 24 mg weekly for 3 months
(ivermectine 400 mcg/per kg body wt/weekly)
HYDROXYCHLOROQUINE PROPHYLAXIS FOR COVID19
HCQ- 400 mg weekly for 6 months
(can be extended if needed)
IVERMECTIN 24 mg weekly for 3 months
(ivermectine 400 mcg/per kg body wt/weekly)
HYDROXYCHLOROQUINE PROPHYLAXIS FOR COVID19
HCQ- 400 mg weekly for 6 months
(can be extended if needed)
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