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P. D. Mangan Health & Fitness Maximalist 🇺🇸

17 Feb, 10 tweets, 3 min read

Serum albumin, a protein measured by a common lab test, has a large inverse relation with mortality.

Why?

Thread👇

In very old people, albumin was a more important risk marker than traditional risk factors such as HDL, LDL, and HbA1c.
nature.com/articles/s4146…

"serum albumin concentration is inversely related to mortality risk in a graded manner over its entire range"

in both healthy people and those with acute or chronic illness.
sciencedirect.com/science/articl…

But, low albumin is NOT a consequence of normal aging.

So, what's going on?

academic.oup.com/geronj/article…

While there are suggestions that low albumin is a sign of undetected illness...

albumin is also associated with loss of muscle mass.

academic.oup.com/ajcn/article/8…

"the increased risk of disability with low serum albumin concentrations observed in the elderly may actually reflect an association with sarcopenia."

Sarcopenia = pathological muscle loss
academic.oup.com/ajcn/article/6…

Old age is not a cause of low albumin, but is associated with muscle loss

and indicates malnutrition.

Low dietary protein leads to lower albumin synthesis.

jci.org/articles/view/…

Albumin Synthesis Is Diminished in Men Consuming a Predominantly Vegetarian Diet

Since albumin is itself a protein, this points to lower protein intake

academic.oup.com/jn/article/130…

Conclusion: low albumin is a strong risk factor for mortality.

It's associated with low muscle mass and low protein intake.

Increased dietary protein and resistance training may be the best ways to counteract low albumin.

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More from @Mangan150

P. D. Mangan Health & Fitness Maximalist 🇺🇸

@Mangan150

19 Feb

Calorie restriction is the surest, most potent method of slowing aging extending lifespan in animals - and, presumably, humans.

Why?

Thread👇

Over 85 years ago, Clive McCay discovered that by feeding his lab rats much less than they would eat on their own, they lived longer - a lot longer.
academic.oup.com/jn/article/140…

Since then, calorie restriction (CR) has been repeated thousands of times, and is the only non-genetic method that has extended lifespan in every species tried.

Clearly, CR targets a process or processes fundamental to living things.

Read 11 tweets

P. D. Mangan Health & Fitness Maximalist 🇺🇸

@Mangan150

16 Feb

The high consumption of seed (vegetable) oils could play a significant role in severe Covid disease, and might even explain between-country variation in mortality.

Thread👇

Omega-6 fatty acids are abundant in seed oils and their consumption leads to a pro-inflammatory state, in turn leading to a cytokine storm which is associated with Covid mortality.

Excessive consumption of linoleic acid, the most abundant component of seed oils, leads to imbalanced tissue fatty acids.

pubmed.ncbi.nlm.nih.gov/28535956/

Read 13 tweets

P. D. Mangan Health & Fitness Maximalist 🇺🇸

@Mangan150

29 Jan

An underlying cause, or effect, or both, of aging, is inflammation.

This is so characteristic of aging that it's been dubbed "inflammaging".

Where does the inflammation come from?

Could be from "garb-aging", the presence of molecular garbage, or from bacterial LPS.
journals.plos.org/plosone/articl…

Inflammation in general is mediated by prostaglandins in turn derived from arachidonic acid.

Resolvins, which dampen inflammation, are made from omega-3 fatty acids.

Read 7 tweets

P. D. Mangan Health & Fitness Maximalist 🇺🇸

@Mangan150

26 Jan

Stanford study reveals immune driver of brain aging

Blocking PGE2 reverses mental decline, restores brain metabolism.

But where does PGE2 come from?
eurekalert.org/pub_releases/2…

PGE2 is made from arachidonic acid, in turn made from membrane phospholipids.

The composition of membrane phospholipids depends on the ratio of omega-6 to omega-3 fatty acids in the diet.

The more omega-6 that people consume, the greater the amount of arachidonic acid in cell membranes.

More omega-3 (from fish or fish oil), the more DHA in membranes and less AA.
sciencedirect.com/science/articl…

Read 5 tweets

P. D. Mangan Health & Fitness Maximalist 🇺🇸

@Mangan150

12 Jan

Top 10 things that health authorities got wrong, by request.

Time for a thread 👇

1. Pride of place must go to saturated fat as a putative contributor to coronary heart disease.

From this mistake, many others follow.

Though they're still pounding on this drum, we now know that saturated fat is NOT associated with heart disease.
bmj.com/content/351/bm…

2. Meat

Despite all the propaganda, vegetarians do not live longer than meat eaters.

A recent review published by the Annals of Internal Medicine found the evidence against meat so weak that we need not change our meat-eating habits.

acpjournals.org/doi/10.7326/M1…

Read 12 tweets

P. D. Mangan Health & Fitness Maximalist 🇺🇸

@Mangan150

18 Dec 20

Majority of people with chronic fatigue syndrome reported nearly complete resolution of symptoms when they took an amino acid supplement.

For many, relief happened in days.

CFS patients have abnormal levels of amino acids suggestive of a chronic catabolic [breakdown] state.

Why important? Amino acids come from protein; patients improving with amino acids suggests they don't get enough protein.

journals.sagepub.com/doi/abs/10.318…

This could explain low energy in vegans, and the improvement in energy so many people report when they add meat (or more meat) to their diets.

Chronic fatigue syndrome might be another manifestation of poor health due to dietary guidelines that told us to avoid meat.

Read 4 tweets

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