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Mac n’ Chise 🧬🧫🦠 Profile picture
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22 Feb, 8 tweets, 3 min read
Wonderful news this morning! A study out of Scotland has found by the fourth week after receiving an initial dose, Pfizer’s and Oxford-AstraZeneca’s vaccines were shown to reduce the risk of hospitalization from COVID in Scotland by up to 85% and 94%, respectively!
Also keep in mind this is just after the initial dose! This means we have more encouraging numbers to look forward to after individuals receive their booster. This is why every vaccine is vital. One study alone does not determine its value.
While we are waiting for the preprint Daily Mail UK provided some graphics from the study. Researchers specified the risks only appear to wear off after four weeks because of a lack of data- not because immunity wears off.
As soon as the preprint is up I’ll post it!
Let’s make sure we are all on the same page. For those asking about AstraZeneca: there is a difference between reduction in cases (the 62% we saw in earlier trials and 76% in more current ones). AstraZeneca's 94% here refers to a reduction in hospitalization and therefore a
reduction in you being seriously ill. The most recent 76% we have seen refers to the reduction in cases and therefore the reduction in being infected. Remember, one study does not determine the value of a vaccine. Also- overlapping CI values you see are hazard ratios (just FYI).
Full preprint can be found here:
drive.google.com/file/d/162PJKb…

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Mac n’ Chise 🧬🧫🦠 Profile picture
20 Feb
This is SO encouraging! More data out of the study conducted by Pfizer and Israel’s Health Ministry I spoke about on a recent thread shows increased effectiveness of Pfizer’s across the board 14 days from the second dose. Remember that second dose is vital!
95.8% at preventing SARS-CoV-2 infection
98% at preventing disease with fever or respiratory symptoms
98.9% at preventing COVID-19 hospitalizations
99.2% at preventing severe disease
98.9% at preventing death from COVID-19
That’s real-world data for you!
Also yes, let me clarify, they specified this was regardless of whether asymptomatic infection or not. I think we need to really start acknowledging these vaccines do indeed reduce transmission of SARS-CoV-2.
Read 4 tweets
Mac n’ Chise 🧬🧫🦠 Profile picture
20 Feb
Vaccines are preventives, not cures.
The purpose of vaccination is to bring the severity level down to that of a benign virus. That’s how this works. Our best protection is to keep cases low and get people vaccinated. To expect eradication of this virus right now is unrealistic.
With this said, the more people vaccinated, the more restrictions should start to be lifted. Why? We are already starting to see evidence these vaccines do prevent transmission the more data comes out; it would be extremely ignorant to suggest otherwise or disregard it.
Eradicating this virus right now from the world is a lot like trying to dig a tunnel to the center of the Earth using only a plastic spoon. It’s unrealistic. Some forget or simply don’t care (totally different virus) but Polio was endemic before it was 100% declared eradicated.
Read 13 tweets
Mac n’ Chise 🧬🧫🦠 Profile picture
18 Feb
For those of you in the UK, this is wonderful news! Real-world data from the UK’s vaccine rollout program revealed just one dose of Oxford/AstraZeneca’s or Pfizer’s vaccines appear to block transmission and infection by two-thirds regardless of age group!
telegraph.co.uk/news/2021/02/1…
And if you’d like some more good news: AstraZeneca has confirmed 100% protection against severe disease, hospitalization and death in their primary analysis of Phase III trials more than 22 days after the first dose. The trials were done in the UK, Brazil AND South Africa.
Increased efficacy with longer inter-dose interval, protection of over 70% starting after a first dose and first indication of reduction in disease transmission of up to 67%.
papers.ssrn.com/sol3/papers.cf… and

astrazeneca.com/media-centre/p…
Read 4 tweets
Mac n’ Chise 🧬🧫🦠 Profile picture
18 Feb
This is extremely promising. A new study conducted by Pfizer and Israel’s Health Ministry shows Pfizer’s vaccine was estimated to be 89.5% effective at preventing SARS-CoV-2 infections regardless of whether symptomatic or not. This infers a possible reduction in transmission! 🧵
Study is based on real-world data and analysis of individuals vaccinated with their 2nd dose.
90% Drop in infection
Effectiveness:
94% against symptomatic infection
94% against severe/crit. hospitalization
93% against death
This study can be found here (just see the screens).
The next two studies I want to highlight take into account viral load. When an infected individual has a high viral load, they are more likely to shed more viral particles, hence transmit the virus. Higher viral load is usually associated with severe disease as well. Carrying on.
Read 14 tweets
Mac n’ Chise 🧬🧫🦠 Profile picture
17 Feb
Ready for some good news?

Lab studies suggest Pfizer’s and Moderna’s vaccines CAN protect against SARS-CoV-2 variants B.1.351 and B.1.1.7. Despite reduction, neutralizing titer levels with B.1.351 remain above levels that are expected to be protective!
cnn.com/2021/02/17/hea…
In addition, they found NO reduction in efficacy against the B.1.1.7 variant! It’s a good day!
Preliminary reports can be found here:
Pfizer: nejm.org/doi/full/10.10…
Moderna: nejm.org/doi/full/10.10…
Wanted to share more this morning concerning safety and efficacy of these vaccines that might put some of you with delayed Pfizer doses at ease. One dose of Pfizer’s vaccine was found to be highly efficacious, with a vaccine efficacy of 92.6%, similar to the first-dose efficacy
Read 5 tweets
Mac n’ Chise 🧬🧫🦠 Profile picture
17 Feb
I want to bring this up. I’m sure by now you have seen those sensationalist headlines about variants merging and “heavily mutated hybrids” and what not. Guess what I want you to do right now? Ignore them. Yes, ignore them. Know why? Things like this are just mass hysteria.
The ones we need to be paying attention to are B.1.1.7, B.1.351 and P.1 because these are the only known SARS-CoV-2 variants that HAVE been shown to possess any evidence of functional significance or biological properties that make them a cause for concern to date. The rest?
Forget them. I read one article and I quote: “the recombination event may have occurred within the sample after it was taken from the infected person, not while it was inside their body. In which case it is an accidental laboratory artefact, not a wild virus.” Makes my head hurt.
Read 6 tweets

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