So I think these top experts studying the origins are very very confused.
They’re looking for the ancestral origins of SARS2 in bats.
But finding the proximal origins of the virus shouldn’t take a decade.
Unfortunately, it looks like China was not interested in following up to identify these proximal origins of SARS2, whether by intermediate host, by a person travelling from South China (SARS spillover zone and location of closest SARS2-like viruses) or research-related incident.
Between the ancestral natural version of SARS2 and the SARS2 we see today- we don’t know what transpired.
We don’t know if it passed through an illegally trafficked animal.
We don’t know if it was sampled from an animal or human by a lab. If it was studied and maybe edited.
We could keep sampling animals (bats) and maybe one day find a closer SARS2 match than the viruses in Yunnan, China.
But it is unclear whether this process will
1. discover another SARS virus with an FCS insertion or
2. reveal how SARS2 traveled 1000 miles to Wuhan.
The 3rd major misunderstanding:
“If SARS2 leaked from a lab, wouldn’t the (Wuhan) lab have published its precursors or admitted to their accident by now?”
This perspective imo reflects a lack of understanding of how things work in academia and in China.
Even if SARS2 leaked from a lab and the lab personnel wanted to confess, I don’t think that option is on the table without very severe penalties for the person and their families and colleagues in China.
As it is a citizen journalist is tortured and sentenced to 4 years prison.
The suggestion that a scientist who knows what happened could just submit a letter to a top journal... is laughable.
You think their emails and activities aren’t being watched? That they can trust an editor (at a journal potentially with Chinese $ interests) not to turn them in?
Does anyone know what happened to Botao Xiao and Lei Xiao, the husband and wife scientists in Wuhan who published a preprint letter in Feb 2020, saying that the virus could’ve come from a Wuhan lab? washingtonpost.com/opinions/globa…
The last major misunderstanding I want to address in this thread:
“Lab origin proponents believe SARS2 was made using RaTG13.”
This is a straw man imo. Most scientists who are asking for an investigation of lab origins are not suggesting that RaTG13 was transformed into SARS2.
I hope this can guide journalists in trying to understand what a virus leaked from a lab might look like:
A few non-scientist lab origin proponents have rushed to claim that RaTG13 is the “smoking gun” backbone of Sars2. This is so obviously incorrect that it gives natural origins proponents (scientists) the opportunity to call out their opponents’ lack of scientific training.
This focus on RaTG13 as a backbone distracts from actual issues with RaTG13: WIV was not forthcoming with its sample history, when it was sequenced, and its link to miners who sickened with a SARS-like pneumonia in 2012; these cases were followed up by top pathogen labs in China.
It also distracts from the fact that the WIV took their massive wildlife pathogen database offline and altered the data in it shortly after covid emerged in Wuhan - the data describing more than 22,000 pathogen samples collected across China over the years.
@TheJohnSudworth@BBC had asked Dr Shi ZL at the WIV about this database and why it was taken down. Shi said it was for security reasons.
@lemondefr confirmed that the database used to exist online but was taken down.
The @WSJ article by @betswrites points out that the @WHO convened team could not properly look into lab origins hypotheses because they were not given access to lab records and databases.
I think it is very important to access the WIV database and see what was altered and when.
Starting to wonder how many virus samples are sitting in freezers waiting to be sequenced.
The newest pangolin CoV in GISAID (EPI_ISL_610156) was collected in Yunnan in 2017. Someone implied that this was proof of the 2019 Guangdong pangolin CoV, but it's quite different...
The Yunnan pangolin CoV sequence is full of gaps, missing front half of the Spike, no RBD to even compare with the SARS2-like RBD in the Guangdong pangolin CoV.
Not sure why anyone would think this Yunnan pangolin CoV is useful to verifying the history of the GD pangolin CoV.
Meanwhile, the Guangdong pangolin CoV authors who haven't provided any of the novel raw data mentioned in their May 2020 @PLOSPathogens paper just released more short sequence fragments for another paper? ncbi.nlm.nih.gov/popset?DbFrom=…
“scientists expressed surprise and even disbelief that the further investigations, into both the first patient's contact history and the supply chain to the Huanan market that the WHO sought, had apparently not already been performed by China.” cnn.com/2021/02/21/chi…
“specialist Daniel Lucey.. said it was “frankly implausible” that such testing had not been done. “My question is why would it not have been done? It was known to be necessary and it’s in China’s scientific.. public health.. national security interest”” scmp.com/news/china/sci…
This would be like if in Stranger Things, the protagonists all neglected to investigate the local National Laboratory while searching for the inter-dimensional gateway (source of spillover).
Am I getting this right? The @WHO convened team heard from an index case that there was a 2nd market but because the meeting ended, they didn’t get details or even the name of the market.
Also, before the WHO-convened team went to Wuhan, Chinese scientists had already tested 10,000s of animal samples including from around Wuhan city and Hubei province - all negative for SARS2. Can the team access the data in higher resolution? Which markets and farms were checked?
A timeline of when results were known would also be exceedingly helpful. The @WSJ reported on this in May 2020, eg OIE was informed on Jan 31, 2020 that no animals at the Huanan market tested positive for SARS2. wsj.com/articles/china…
Feb 9, we heard from WHO-convened team (which is 50% scientists in China, 50% international) they were going to stop looking into "extremely unlikely" lab origins & start investigating #PopsicleOrigins
One team member said this decision was to "respect" the Chinese counterparts.
Feb 22, one of WHO-convened team members says the COVID-19 virus could've come from Thailand, even naming one market.
DESPITE closest relatives to SARS-CoV-2 being from China
DESPITE the virus in Thailand not even using the same human receptor 🤯
Jan 2020 China said the virus likely came from wild animals sold at the Wuhan seafood market. May 2020 they said the market was just a later cluster, not the origin.
Since then, they've suggested that covid-19 was imported into China through cold chain.
On Jan 15, 2021, the previous US State Department released this Facts Sheet on the origins of COVID-19 raising concerns about SARS + other pathogen research at the WIV.
However, it was swiftly archived by the new administration.
On @FaceTheNation ex-Deputy National Security Adviser Matt Pottinger said that this had been "scrubbed by every department within every bureau within the State Department, was looked at very carefully by the NSC staff, intelligence officers, HHS" cbsnews.com/video/former-d…