Xi Thought of the Day:
Is it all an unfortunate misunderstanding? Are certain journalists mired in confusion and unclearness? Do certain scientists have problems keeping their story straight? Liberate your mind! Seek truth from facts!
Is it all an unfortunate misunderstanding? Are certain journalists mired in confusion and unclearness? Do certain scientists have problems keeping their story straight? Liberate your mind! Seek truth from facts!
3/
tfw you book tickets to Wuhan on a whim
tfw you book tickets to Wuhan on a whim
https://twitter.com/waittwoweeks/status/1364749243777441795
4/
No wait he was part of the Science Team
No wait he was part of the Science Team
https://twitter.com/waittwoweeks/status/1364886176059039747
6/
"Early days they did not do enough but they did not know [the virus]"
Were you in Wuhan in connection with this outbreak?
"Early days they did not do enough but they did not know [the virus]"
Were you in Wuhan in connection with this outbreak?
7/
"I went there because I have existing collaborations so I booked the flights before the outbreak."
Oh!
"I went there because I have existing collaborations so I booked the flights before the outbreak."
Oh!
8/
"Errr because I'm y'know uh uh uh uh a scientist virologist working this field for 25 years so of course I want to take this PRE-ARRANGED opportunity to learn something first hand on the ground."
I see!
"Errr because I'm y'know uh uh uh uh a scientist virologist working this field for 25 years so of course I want to take this PRE-ARRANGED opportunity to learn something first hand on the ground."
I see!
9/
"Actually I have been invited to this [emergency WHO] meeting as well."
"Actually I have been invited to this [emergency WHO] meeting as well."
10/
“We should be paying more attention to cases in other countries. For me, the better indicator is overseas,” he said, adding that so far he has not seen a repeat of the 2002-03 Severe Acute Respiratory Syndrome (SARS) outbreak that killed hundreds of people.
“We should be paying more attention to cases in other countries. For me, the better indicator is overseas,” he said, adding that so far he has not seen a repeat of the 2002-03 Severe Acute Respiratory Syndrome (SARS) outbreak that killed hundreds of people.
11/
Wang said he “tends to be more positive” that early detection and awareness of the outbreak, as well as the response of other countries, are helping control the spread of the disease abroad.
archive.is/0zBMc
Wang said he “tends to be more positive” that early detection and awareness of the outbreak, as well as the response of other countries, are helping control the spread of the disease abroad.
archive.is/0zBMc
12/
Implicitly dates outbreak beginning to 1 Dec
"China much more transparent"
You were in Wuhan just recently, right?
"Pre-arranged, only 1% people wearing masks, flu is still the number one threat"
Implicitly dates outbreak beginning to 1 Dec
"China much more transparent"
You were in Wuhan just recently, right?
"Pre-arranged, only 1% people wearing masks, flu is still the number one threat"
14/
"North Korea, which is economically reliant on China for tourists, trade and investment, was the first neighbouring country to ban Chinese tourist arrivals. The ban went into effect on Jan 22."
"North Korea, which is economically reliant on China for tourists, trade and investment, was the first neighbouring country to ban Chinese tourist arrivals. The ban went into effect on Jan 22."
15/
December 2019
Nipah experimental vaccine... CEPI established at WEF 2017... Fookin get in there Nipah my son 50% fatality nice one
December 2019
Nipah experimental vaccine... CEPI established at WEF 2017... Fookin get in there Nipah my son 50% fatality nice one
16/
@WhereIsYanLing @uacjess @BillyBostickson @still_a_nerd @Daoyu15 @rubic3n @jhas5 @sleeplessbkk @LynnFynn3
"It's a highly, highly fatal disease, but it's not very transmissible... yet! [grins]"
@WhereIsYanLing @uacjess @BillyBostickson @still_a_nerd @Daoyu15 @rubic3n @jhas5 @sleeplessbkk @LynnFynn3
"It's a highly, highly fatal disease, but it's not very transmissible... yet! [grins]"
17/
Yeah the Wuhan Coronavirus is a little too mainstream for me I'm actually into Nipah now... you've probably never heard of it
Yeah the Wuhan Coronavirus is a little too mainstream for me I'm actually into Nipah now... you've probably never heard of it
18/
Wang's played a cheeky one down the wing to Nipah... he's dodged the immune system, only the major organs to beat... and... and HE'S ONLY GONE AND BURIED IT... top corner... *catches breath*... simply an honour to witness moments like this... 50% shot conversion... special
Wang's played a cheeky one down the wing to Nipah... he's dodged the immune system, only the major organs to beat... and... and HE'S ONLY GONE AND BURIED IT... top corner... *catches breath*... simply an honour to witness moments like this... 50% shot conversion... special
19/
Frederik Kristensen: "Most of these emerging infectious diseases as we call them like the Nipah virus have evolved from the animal kingdom and jump over to the human side and then they have the potential of spreading from human to human." @BillyBostickson
Frederik Kristensen: "Most of these emerging infectious diseases as we call them like the Nipah virus have evolved from the animal kingdom and jump over to the human side and then they have the potential of spreading from human to human." @BillyBostickson
20/
FK 5:15 "In addition to actually trying to develop some platforms that could be adopted to any new pathogen that could arise."
FK 5:15 "In addition to actually trying to develop some platforms that could be adopted to any new pathogen that could arise."
22/
Q: Could airflow between cages in the BSL-4 facilities
contribute to transmission?
A: Yes, with easily transmissible pathogens,
transmission has been observed across cages due
to the forced airflow of BSL-4 facilities.
cepi.net/wp-content/upl…
Q: Could airflow between cages in the BSL-4 facilities
contribute to transmission?
A: Yes, with easily transmissible pathogens,
transmission has been observed across cages due
to the forced airflow of BSL-4 facilities.
cepi.net/wp-content/upl…
23/
ChAdOx1- and ChAdOx2-vectored
vaccines have been developed for
a wide range of EIDs, including
MERS, Lassa, Nipah, and Ebola
ChAdOx1- and ChAdOx2-vectored
vaccines have been developed for
a wide range of EIDs, including
MERS, Lassa, Nipah, and Ebola
24/
"Herpes viruses (HVs)
naturally stimulate very strong
T-cell responses, and this property
is being exploited to develop HV
vector vaccines with the potential
to elicit strong cell-mediated
immunity."
I'm immune bros 😎🥳
"Herpes viruses (HVs)
naturally stimulate very strong
T-cell responses, and this property
is being exploited to develop HV
vector vaccines with the potential
to elicit strong cell-mediated
immunity."
I'm immune bros 😎🥳
25/
"Hopefully, this sort of initiative will go down in history as the beginning of the end of pandemic risk."
"Hopefully, this sort of initiative will go down in history as the beginning of the end of pandemic risk."
26/
"Moreover, a casereport from 2012 of a woman who
had presented with late-onset
Nipah encephalitis 11 years after
the initial outbreak in Malaysia,
questioned the original conclusion
that the Malaysia outbreak did
not involve human-to-human
transmission"
"Moreover, a casereport from 2012 of a woman who
had presented with late-onset
Nipah encephalitis 11 years after
the initial outbreak in Malaysia,
questioned the original conclusion
that the Malaysia outbreak did
not involve human-to-human
transmission"
27/
"Published
data on viral shedding was only
available for 37 patients, in which
shedding was documented in oral/
nasal swabs as well as in urine,
but only during acute infection.
Viral shedding in semen was
documented in one Indian case"
"Published
data on viral shedding was only
available for 37 patients, in which
shedding was documented in oral/
nasal swabs as well as in urine,
but only during acute infection.
Viral shedding in semen was
documented in one Indian case"
28/
"However,
it was not possible to isolate the
replicating virus. While flying foxes
were not formally confirmed to
serve as reservoir in this outbreak,"
"However,
it was not possible to isolate the
replicating virus. While flying foxes
were not formally confirmed to
serve as reservoir in this outbreak,"
29/
"Using reverse genetics, the
Edmonston MV strain was
genetically modified to incorporate
the NiV G protein and create a
recombinant NiV vaccine strain
(rMV-Ed-NiVG)."
"Using reverse genetics, the
Edmonston MV strain was
genetically modified to incorporate
the NiV G protein and create a
recombinant NiV vaccine strain
(rMV-Ed-NiVG)."
30/
"The University of Queensland is
developing a “molecular clamp”
platform technology, which
enables trimerisation of viral
surface proteins, thereby exposing
the surface protein’s epitope
that is primarily responsible for
inducing neutralising antibodies."
"The University of Queensland is
developing a “molecular clamp”
platform technology, which
enables trimerisation of viral
surface proteins, thereby exposing
the surface protein’s epitope
that is primarily responsible for
inducing neutralising antibodies."
31/
"Importantly, there are a number of
class I and III envelope proteins of
human and veterinary importance,
including MERS coronavirus"
"Importantly, there are a number of
class I and III envelope proteins of
human and veterinary importance,
including MERS coronavirus"
32/
"The molecular clamp
is a trimerisation domain based
on the six-helix bundle of human
immunodeficiency virus (HIV)
gp41, providing very high stability
and a melting temperature of about
90 °C."
"The molecular clamp
is a trimerisation domain based
on the six-helix bundle of human
immunodeficiency virus (HIV)
gp41, providing very high stability
and a melting temperature of about
90 °C."
33/
"Marketability of NiV vaccines for
pigs may be challenging due to the
sporadic nature of NiV outbreaks.
An alternative strategy could
be to include NiV antigen in a
vaccine that is already widely used, creating a bivalent vaccine"
"Marketability of NiV vaccines for
pigs may be challenging due to the
sporadic nature of NiV outbreaks.
An alternative strategy could
be to include NiV antigen in a
vaccine that is already widely used, creating a bivalent vaccine"
34/
Therapeutic remdesivir treatment protects African green monkeys from lethal Nipah virus, Bangladesh challenge
Dr. Emmie de Wit, Laboratory of Virology, NIAID, NIH
Notes from this presentation are not available.
Therapeutic remdesivir treatment protects African green monkeys from lethal Nipah virus, Bangladesh challenge
Dr. Emmie de Wit, Laboratory of Virology, NIAID, NIH
Notes from this presentation are not available.
35/
"Now,
the ambition is to develop a
fusion-blocking peptide in the
form of a nasal spray that can
be used prophylactically against
henipavirus infection."
"Now,
the ambition is to develop a
fusion-blocking peptide in the
form of a nasal spray that can
be used prophylactically against
henipavirus infection."
36/
2: Inter-nation collaboration
Sino-French NiV taskforce
Dr. Zhengli Shi, Wuhan Institute of Virology
@BillyBostickson
"In addition, they offer an
international BSL-4 biosafety
training course in an annual
call around September"
2: Inter-nation collaboration
Sino-French NiV taskforce
Dr. Zhengli Shi, Wuhan Institute of Virology
@BillyBostickson
"In addition, they offer an
international BSL-4 biosafety
training course in an annual
call around September"
37/
mfw biosafety training
mfw biosafety training
38/
Look this fool
Look this fool
40/
KUALA LUMPUR, Feb 3 — The novel coronavirus could have originated outside China, an international zoonotic disease expert said, as immune responses and the virus were discovered in Italy, Singapore and Spain before the Wuhan outbreak.
KUALA LUMPUR, Feb 3 — The novel coronavirus could have originated outside China, an international zoonotic disease expert said, as immune responses and the virus were discovered in Italy, Singapore and Spain before the Wuhan outbreak.
41/
“Here are two papers, one from Singapore. Studied specific T cell response to SARS-Cov-2 and we found that before 2019, we already have people with T cell immunity to the virus,” Wang told the panel.
“Here are two papers, one from Singapore. Studied specific T cell response to SARS-Cov-2 and we found that before 2019, we already have people with T cell immunity to the virus,” Wang told the panel.
42/
According to Wang, the ancestral virus of Covid-19 is from bats, which was quickly identified five days after the Wuhan outbreak, but the intermediate host that transmits the virus from animal to human is still unknown.
According to Wang, the ancestral virus of Covid-19 is from bats, which was quickly identified five days after the Wuhan outbreak, but the intermediate host that transmits the virus from animal to human is still unknown.
43/
“So, there was a lot of mention about the Huanan Seafood Market in Wuhan. What we see is that in this market, you have a menu, they sold everything,” Wang said during his topic on ‘The origin of SARS-CoV2: Bats, pangolins, rodents or more?’
“So, there was a lot of mention about the Huanan Seafood Market in Wuhan. What we see is that in this market, you have a menu, they sold everything,” Wang said during his topic on ‘The origin of SARS-CoV2: Bats, pangolins, rodents or more?’
44/
Counterpoint: Connor Reed testimony + numerous disappointingly normal looking videos @WhereIsYanLing
Counterpoint: Connor Reed testimony + numerous disappointingly normal looking videos @WhereIsYanLing
45/
Professor Thomas Coffman, Dean of Duke-NUS, said, “We are extremely proud of Linfa for being elected to this prestigious Academy. This is a testament to his passion, leadership and tremendous contributions to the field of infectious diseases."
duke-nus.edu.sg/eid/allnews/ne…
Professor Thomas Coffman, Dean of Duke-NUS, said, “We are extremely proud of Linfa for being elected to this prestigious Academy. This is a testament to his passion, leadership and tremendous contributions to the field of infectious diseases."
duke-nus.edu.sg/eid/allnews/ne…
46/
Genetics Department Seminar Series: "Bats as Reservoir of Emerging Zoonotic Viruses"
Speaker
Duke-NUS Medical School, Singapore
Linfa Wang, PhD
medicine.yale.edu/compmed/event/…
Genetics Department Seminar Series: "Bats as Reservoir of Emerging Zoonotic Viruses"
Speaker
Duke-NUS Medical School, Singapore
Linfa Wang, PhD
medicine.yale.edu/compmed/event/…
48/
Groundbreaking cPass Test is set to aid the recovery of Travel Industry across the globe.
The cPass test, being called the immunity passport, has been invented by a team headed by Professor Wang Linfa
web.archive.org/web/2021030205…
Groundbreaking cPass Test is set to aid the recovery of Travel Industry across the globe.
The cPass test, being called the immunity passport, has been invented by a team headed by Professor Wang Linfa
web.archive.org/web/2021030205…
49/
Location:
22 October 2019 Singapore 9 December 2019 Singapore
Location:
22 October 2019 Singapore 9 December 2019 Singapore
50/
"Genius...Linfa Wang introducing the BatMouse - bone marrow chimaera to generate a bat immune system in the mouse."
@BillyBostickson @Daoyu15 @uacjess @WhereIsYanLing
"Genius...Linfa Wang introducing the BatMouse - bone marrow chimaera to generate a bat immune system in the mouse."
@BillyBostickson @Daoyu15 @uacjess @WhereIsYanLing
51/
WE HAVE THE TECHNOLOGY
WE HAVE THE TECHNOLOGY
52/
All this and he's got time for literally scores of interviews as well: "over 100 interviews since January" (10 May 2020)
scholarbank.nus.edu.sg/cris/rp/rp0614…
All this and he's got time for literally scores of interviews as well: "over 100 interviews since January" (10 May 2020)
scholarbank.nus.edu.sg/cris/rp/rp0614…
53/
Unlocking bat immunology: establishment of Pteropus alecto bone marrow-derived dendritic cells and macrophages
2016
nature.com/articles/srep3…
Unlocking bat immunology: establishment of Pteropus alecto bone marrow-derived dendritic cells and macrophages
2016
nature.com/articles/srep3…
54/
"These resources were previously limited due to constant need of catching wild bats and the lack of research-oriented bat colonies for fresh materials. We show that such immune cells can be generated in large enough quantities for functional studies"
"These resources were previously limited due to constant need of catching wild bats and the lack of research-oriented bat colonies for fresh materials. We show that such immune cells can be generated in large enough quantities for functional studies"
55/
Seuche Santa
Seuche Santa
56/
Second row, far right gets it
Second row, far right gets it
58/
Differential stepwise evolution of SARS coronavirus functional proteins in different host species
bmcecolevol.biomedcentral.com/track/pdf/10.1…
Differential stepwise evolution of SARS coronavirus functional proteins in different host species
bmcecolevol.biomedcentral.com/track/pdf/10.1…
59/
60/
This room contains: Ebola | Hendra | Nipah | SARS
bohointeractive.com/2012/aahl/
web.archive.org/web/2021022823…
This room contains: Ebola | Hendra | Nipah | SARS
bohointeractive.com/2012/aahl/
web.archive.org/web/2021022823…
61/
"Wang told us about a range of poorly thought out system-wide responses like colony moving. Many of these have had unintended consequences. With the recent spate of Hendra cases in 2011, there is the possibility that human responses to bats have in fact exacerbated the issue
"Wang told us about a range of poorly thought out system-wide responses like colony moving. Many of these have had unintended consequences. With the recent spate of Hendra cases in 2011, there is the possibility that human responses to bats have in fact exacerbated the issue
62/
"To test whether bats somehow need these viruses as part of their biological function, AAHL has bred a Specifically Pathogen Free (SPF) colony of virus-free bats for observation."
"To test whether bats somehow need these viruses as part of their biological function, AAHL has bred a Specifically Pathogen Free (SPF) colony of virus-free bats for observation."
63/
"AAHL is a fortress spread over several levels, with a working level in the middle, plantroom levels above and below, and the whole thing encased in an impermeable concrete shell. Whole floors are devoted to waste management and air filtration."
"AAHL is a fortress spread over several levels, with a working level in the middle, plantroom levels above and below, and the whole thing encased in an impermeable concrete shell. Whole floors are devoted to waste management and air filtration."
64/
"Similar facilities designed around the time of AAHLs construction may use ten to twenty world-class HEPA filters throughout the building. AAHL uses more than a thousand, with every individual airspace filtered and controllable individually (down to each shower cubicle)."
"Similar facilities designed around the time of AAHLs construction may use ten to twenty world-class HEPA filters throughout the building. AAHL uses more than a thousand, with every individual airspace filtered and controllable individually (down to each shower cubicle)."
65/
"Nothing comes out of the bunker’s secure area without decontamination – waste materials are separated according to their threat level and thoroughly roasted in these drums."
"Nothing comes out of the bunker’s secure area without decontamination – waste materials are separated according to their threat level and thoroughly roasted in these drums."
66/
67/
"During our tour a new suite of labs was being prepared to be used for the first time, which entails decontaminating the rooms completely by burning a whole lot of formaldehyde in special woks (on the desk connected to the orange cable at the far end in this image)"
"During our tour a new suite of labs was being prepared to be used for the first time, which entails decontaminating the rooms completely by burning a whole lot of formaldehyde in special woks (on the desk connected to the orange cable at the far end in this image)"
68/
"Linfa Wang, DGHI professor and director of the Emerging Infectious Diseases Programme at Duke-NUS Medical School, is not *technically* a superhero"
$$$
globalhealth.duke.edu/news/dghi-prof…
"Linfa Wang, DGHI professor and director of the Emerging Infectious Diseases Programme at Duke-NUS Medical School, is not *technically* a superhero"
$$$
globalhealth.duke.edu/news/dghi-prof…
69/
Researchers at Duke-NUS are studying the cave nectar bat (Eonycteris spelaea) to learn more about the bat’s immune system. @BillyBostickson @still_a_nerd
Researchers at Duke-NUS are studying the cave nectar bat (Eonycteris spelaea) to learn more about the bat’s immune system. @BillyBostickson @still_a_nerd
70/
71/
"Prof Wang travelled regularly to China to meet colleagues. His trip had been scheduled since early December."
@BillyBostickson @uacjess @WhereIsYanLing @sleeplessbkk @jhas5 @rubic3n
"Prof Wang travelled regularly to China to meet colleagues. His trip had been scheduled since early December."
@BillyBostickson @uacjess @WhereIsYanLing @sleeplessbkk @jhas5 @rubic3n
72/
GET IN HERE NIPAHCHADS
TWiV 618: Nipah virus at 20
Singapore 10 December 2019 with Wang and Epstein (cf. TWiV 501)
GET IN HERE NIPAHCHADS
TWiV 618: Nipah virus at 20
Singapore 10 December 2019 with Wang and Epstein (cf. TWiV 501)
73/
Linfa: HIT THAT MFUGGIN PUBLICITY BUTTON
"If you can eradicate a disease... the scientists will be out of a job"
What would the people in this room be doing if there were no Nipah? "There would be Disease X"
Linfa: HIT THAT MFUGGIN PUBLICITY BUTTON
"If you can eradicate a disease... the scientists will be out of a job"
What would the people in this room be doing if there were no Nipah? "There would be Disease X"
74/
He wants a Nipah movie, of course he does
"Lipkin got a cameo in Contagion" u jelly
👎: doing boring science stuff
👍: unleashing the bat death so you can spend 5 hours in hair and make up to be on screen for .5 seconds pretending to drink coffee
He wants a Nipah movie, of course he does
"Lipkin got a cameo in Contagion" u jelly
👎: doing boring science stuff
👍: unleashing the bat death so you can spend 5 hours in hair and make up to be on screen for .5 seconds pretending to drink coffee
75/
c21:30
John: "There's a whole industry, if you like, of finding new viruses in bats... A new virus can arise anywhere, anytime, anyplace."
Peter DASSSHHHAK 'proves LW right RE bat reservoir'. LW: 'The only time in my career I was happy a competitor got published in Nature'
c21:30
John: "There's a whole industry, if you like, of finding new viruses in bats... A new virus can arise anywhere, anytime, anyplace."
Peter DASSSHHHAK 'proves LW right RE bat reservoir'. LW: 'The only time in my career I was happy a competitor got published in Nature'
76/
$10 billion in grant money, a movie cameo, and human-to-human transmission will come to you but ONLY if you reply
I LOVE YOU NIPAH-CHAN
$10 billion in grant money, a movie cameo, and human-to-human transmission will come to you but ONLY if you reply
I LOVE YOU NIPAH-CHAN
77/
c38:00
weird all these "quite a recent virus"es are turning up
c38:00
weird all these "quite a recent virus"es are turning up
78/
Are virologists not allowed to wear ties???
c46:00
LW: 'CEPI platform... just switch the epitope (??) protein'
LW: "From gene to vaccine in 16 weeks"
@BidoliNicola @BillyBostickson
Are virologists not allowed to wear ties???
c46:00
LW: 'CEPI platform... just switch the epitope (??) protein'
LW: "From gene to vaccine in 16 weeks"
@BidoliNicola @BillyBostickson
79/
RARE WANGS
RARE WANGS
80/
Who runs PR for these guys it's like some mysterious organisation appointed Daszak and Wang CEOs of COVID
archive.is/8xWso
Who runs PR for these guys it's like some mysterious organisation appointed Daszak and Wang CEOs of COVID
archive.is/8xWso
unroll plox @threadreaderapp
• • •
Missing some Tweet in this thread? You can try to
force a refresh
